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All Journal Jurnal Health Sains Journal Of World Science Indonesian Journal of Cancer
Danardono, Edwin
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Role of Liquid Biopsy as a Future Approach to Early Diagnosis and Management of Colorectal Cancer Danardono, Edwin; Soediono, Mochammad Ridhwan; Amiruddin, Muhammad Tidar Abiyu
Indonesian Journal of Cancer Vol 19, No 3 (2025): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i3.1319

Abstract

Colorectal cancer (CRC) is a major global health challenge, ranking as the third most prevalent cancer worldwide. Traditional tumor biopsies are invasive and limited by issues such as tumor heterogeneity and the inability to perform repeated sampling. Liquid biopsy, a non-invasive diagnostic approach that analyzes biomarkers in bodily fluids like blood, offers an innovative solution to these challenges. By detecting circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), exosomes, and tumor-educated platelets (TEPs), liquid biopsy allows for real-time tumor monitoring, early cancer detection, and personalized treatment strategies. This review explores the clinical applications of liquid biopsy in CRC, highlighting its potential for early detection, monitoring treatment response, and guiding customized therapies. Key biomarkers such as CEA, ctDNA, CTCs, and exosomal miRNAs offer insights into tumor dynamics and prognosis. While liquid biopsy shows promise for broad clinical use, challenges remain in standardizing methodologies and validating its efficacy through large-scale trials. Advances in technology and improved biomarker discovery are expected to enhance the accuracy and utility of liquid biopsy, making it a pivotal tool in CRC management and beyond.
Profile of Patients with Bile Duct Injury in RSUD Dr. Soetomo Period January 224-December 2024 Santi, Santi; Danardono, Edwin; Wibowo, Marjono Dwi
Journal of World Science Vol. 4 No. 1 (2025): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v4i1.1295

Abstract

Surgical procedures involving the biliary system are among the most common in digestive surgery. Advances in laparoscopic techniques have increased the frequency of bile duct injuries (BDI), a major contributor to morbidity and mortality, remarkably when unrecognized during surgery, which occurs in 25% to 32.4% of cases. This study describes the characteristics of BDI patients treated at RSUD Dr. Soetomo Surabaya from January to December 2024. Employing an observational analytical design with a cross-sectional approach, data were collected from the medical records of 26 patients meeting inclusion and exclusion criteria. Patients who underwent laparoscopic surgery had a shorter average Length of Stay (LOS) of 12.91 days compared to 23.57 days for those with open surgery. Mortality was observed exclusively among patients with a history of open surgery, notably in BDI type E4 cases. These findings highlight the importance of timely recognition and effective management of BDIs to mitigate their significant impact on patient outcomes.
Desmoid Tumor Patients Profile in Dr. Soetomo Surabaya Hospital: A Rare Event Meidini Rahmat, Beatta; Danardono, Edwin; Wihandono, Asdi
Jurnal Health Sains Vol. 6 No. 1 (2025): Jurnal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v6i1.1462

Abstract

Desmoid tumor (DT) is a fibroblast soft tissue tumor that deep seated connective tissue malignancy developing in musculoaponeurtic tissues. Desmoid tumor is a rare tumor, reported 5-6 cases per million population and account 0.03% of all neoplasm yet the etiopathogenesis of this tumor remains unclear. DT most commonly develops between the age of 15-60 years and common in females, although it rarely metastasized but locally aggressive and affect the adjacent structures. Knowing the profile of desmoid tumor patients at RSUD Dr. Soetomo Surabaya for the period January 2020 – December 2024. Including demographic patients, risk factors, tumor sites, and patients’ managements. All patients between January 2020-December 2024 whose primary DTs were observed. Datas were obtained and observational descriptive study conducted from medical files to record patient’s age, sex, tumor site, and therapeutic managements. All 16 patients were obtained during 5 years with female predominantly (1:4) and adult was more common 19-44 years. Risk factors including in this study were history of trauma, history on pregnancy, and hormonal contraceptive. Location of tumors were found mostly in abdominal wall and the therapy conducted were surgery followed by chemotherapy, and combination of hormonal therapy, TKIs, and radiotherapy. DT is a rare fibroblastic neoplasm that shows locally aggressive behavior with very low incidence annually with female, history of trauma, history of pregnancy, and hormonal contraceptive as a major risk factors. The therapeutic management includes multidisciplinary approach.
Co-Authors Amiruddin, Muhammad Tidar Abiyu Asdi Wihandono Marjono Dwi Wibowo Meidini Rahmat, Beatta Santi Santi Soediono, Mochammad Ridhwan