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All Journal Jurnal Rekayasa Proses Jurnal Ilmiah Farmasi Jurnal Teknosains Indonesian Journal of Biotechnology JURNAL PHARMASCIENCE INDONESIAN JOURNAL OF PHARMACY Pharmascience Majalah Farmaseutik Jurnal Rekayasa Proses Jurnal Rekayasa Proses
Hilda Ismail, Hilda
Faculty Of Pharmacy, Universitas Gadjah Mada, Yogyakartaa, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Education Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Social Sciences

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Journal : Majalah Farmaseutik

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Nanoparticle Preparation of Pentagamavunon-0 Using Medium Viscous Chitosan Matrix Cross Linked by Sodium Tripolyphosphate Through Ionic Gelation Mechanism as Anti-Inflammatory Candidate Adhyatmika Adhyatmika; Ronny Martien; Hilda Ismail
Majalah Farmaseutik Vol 13, No 2 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (405.477 KB) | DOI: 10.22146/farmaseutik.v13i2.40916

Abstract

Pentagamavunon-0 (PGV-0, abbreviated), a curcumin analogue with chemical structure as 2,5-bis(4’-hydroxy-3’-methoxybenzilidin)cyclopentanone, has proven to have anti-inflammatory activity and non-ulcerogenic. However, orally PGV-0 has low bioavailability because of its low solubility. One of the strategy to improve PGV-0 solubility in order to increase bioavailability is using nanoparticle carrier. The aim of the study is to formulate chitosan-PGV-0 nanoparticles through ionic gelation mechanism cross-linked by tripolyphosphate. PGV-0 nanoparticle produced was then characterized for its particle size, morphology, zeta potential, entrapment efficiency, and stability against artificial gastric and intestinal fluids (AGF and AIF). PGV-0 nanoparticle was tested for its anti-inflammatory activity by carrageenan induced inflammatory method, and its enzymatic affinity against enzyme cyclooxygenase (COX)-1 and COX-2. Chitosan-PGV-0 nanoparticles were formulated in the combination of 0,05% PGV-0, 0,05% medium-viscous chitosan and 0,002% TPP. The nanoparticles were 144,37 + 17,41 nm amorphous particles. Amount of PGV-0 entrapped was 99,40 + 0,08 % with +3,8 + 0,27 mV in zeta potential. Stability study in AGF and AIF was shown that 99,64-99,74 % (AGF) and 99,54-99,69 % (AIF) of PGV-0 remains in nanoparticles. Chitosan-PGV-0 nanoparticles at 5 mg/kg body weight was obtain 35,47 % anti-inflammatory activity and has found to have self-affinity against COX enzyme, relatively selective to COX-2.
Co-Authors Adhyatmika Adhyatmika Anggun Feranisa Ari Sudarmanto Arimurni, Dewa Ayu B. S. Ari Sudarmanto Ciptasari, Ummi H. Dwi Titus Indriyawati Endang Lukitaningsih Evi Lande Setiyani Ikhsan, M Arief Nur Indah Tri Nugraha Indah Tri Nur'aini Kurnianto, Rifki Wahyu Lutfi Chabib, Lutfi Martien, Ronny Martien, Ronny Mohammad Fahrurrozi Muhammad Fahrurrozi Pudjono Lukitaningsih Pudjono Pudjono Ratna Asmah Susidarti Ratna Asmah Susidarti Rochmadi Lukitaningsih Rochmadi Rochmadi Ronny Martien Ronny Martien Ronny Martien Ronny Martien S. Sismindari Sismindari, Sismindari Suryani, Fidya Wintari Taurina Yuswanto, Ag