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All Journal Jurnal Penyakit Dalam Indonesia Jurnal Hukum Statuta
Karlina, Arlis
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Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology

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The Effect of Angiotensin-Converting Enzyme GenePolymorphism and Angiotensin II Levels in Coronary SlowFlow Phenomenon at Mohammad Hoesin General HospitalPalembang Karlina, Arlis; Indrajaya, Taufik; Ghanie, Ali; Sukandi, Erwin; Usnizar, Ferry; Indra, Syamsu; Chodilawati, Rukiah; Saleh, Imran
Jurnal Penyakit Dalam Indonesia Vol. 8, No. 2
Publisher : UI Scholars Hub

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Abstract

Introduction. The presence of ACE gene polymorphism is expected to have a role in cardiovascular diseases, including coronary slow flow phenomenon (CSFP). Angiotensin converting enzyme (ACE) gene polymorphism also plays an essential role in increasing angiotensin II levels. Therefore, this study aimed to analyze the effect of angiotensin-converting enzyme gene polymorphism and angiotensin II levels in the coronary slow flow phenomenon in Mohammad Hoesin General Hospital Palembang. Methods. This case-control study was started from July 2019 to July 2020 at RSMH Palembang with 32 subjects for each case (CSFP patients) and the control group (non-CSF patients). This study used a pair of primers and onetimed PCR to detect ACE gene polymorphism. Genetic analysis was carried out in the Biotechnology Laboratory Faculty of Medicine, Universitas Sriwijaya. Statistical analysis was performed using the Spearman correlation test. Results. There were 17 subjects with II genotypes (53.1%), 14 subjects with ID genotypes (43.8%), and 1 subject with DD genotypes (3.1 %) in the CSFP group. While in the non-CSFP group, there were 11 subjects with II genotypes (34.4%), 13 subjects with ID genotypes (42.2%), and 9 subjects with DD genotypes (14.1%). The median value of angiotensin II levels in CSFP and Non-CSF group was 58 pg/mL and 32.8 pg/mL, respectively. The results of the analysis showed that there was an effect of angiotensin II levels on the incidence of CSFP (p=0.001). Further analysis showed that there was a correlation between angiotensin II levels and the I/D 287 bp alu repetitive sequence polymorphism in the intron 16 ACE gene (p=0.030, r=0.822). Conclusions. There was a correlation between I/D 287 bp alu repetitive sequence polymorphism in the intron 16 ACE gene and angiotensin II levels in the coronary slow flow phenomenon at Mohammad Hoesin General Hospital Palembang.
PERAN TNI DI MASA PANDEMI COVID 19 DALAM PERSPEKTIF HUKUM DAN BELA NEGARA Karlina, Arlis
Jurnal Hukum Statuta Vol 2 No 1 (2022): Volume 2, Nomor 1, Desember 2022
Publisher : Fakultas Hukum Universitas Pembangunan Nasional Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35586/jhs.v2i1.3923

Abstract

The TNI, as a national component, is involved in handling the COVID-19 virus and administering COVID-19 vaccinations throughout Indonesia. TNI soldiers have been actively involved on the front lines with Health Workers in battling the COVID-19 pandemic since it first entered Indonesia. The TNI's task in dealing with the epidemic is to carry out Military Operations Other Than War (OMSP), as mandated by TNI Law Number 34 of 2004, namely assisting the Regional Government's tasks and providing humanitarian assistance. As the enforcer of state sovereignty, the TNI plays a variety of roles, including economic, social, cultural, security, health, and logistics distribution. The urgency of TNI involvement in dealing with the COVID-19 pandemic is influenced by risk factors, specifically the very high rate of transmission of the COVID-19 disease outbreak, the ability of civil institutions to deal with COVID-19, and the impact of the COVID-19 pandemic on socioeconomic and political stability of Indonesia as a country.
Co-Authors Ali Ghanie Ferry Usnizar, Ferry Indra, Syamsu Indrajaya, Taufik Rukiah Chodilawati Saleh, Imran Sukandi, Erwin