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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Pengabdian Masyarakat: Humanity and Medicine Jurnal Penyakit Dalam Indonesia
Ali Ghanie
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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The Effect of Angiotensin-Converting Enzyme GenePolymorphism and Angiotensin II Levels in Coronary SlowFlow Phenomenon at Mohammad Hoesin General HospitalPalembang Karlina, Arlis; Indrajaya, Taufik; Ghanie, Ali; Sukandi, Erwin; Usnizar, Ferry; Indra, Syamsu; Chodilawati, Rukiah; Saleh, Imran
Jurnal Penyakit Dalam Indonesia Vol. 8, No. 2
Publisher : UI Scholars Hub

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Abstract

Introduction. The presence of ACE gene polymorphism is expected to have a role in cardiovascular diseases, including coronary slow flow phenomenon (CSFP). Angiotensin converting enzyme (ACE) gene polymorphism also plays an essential role in increasing angiotensin II levels. Therefore, this study aimed to analyze the effect of angiotensin-converting enzyme gene polymorphism and angiotensin II levels in the coronary slow flow phenomenon in Mohammad Hoesin General Hospital Palembang. Methods. This case-control study was started from July 2019 to July 2020 at RSMH Palembang with 32 subjects for each case (CSFP patients) and the control group (non-CSF patients). This study used a pair of primers and onetimed PCR to detect ACE gene polymorphism. Genetic analysis was carried out in the Biotechnology Laboratory Faculty of Medicine, Universitas Sriwijaya. Statistical analysis was performed using the Spearman correlation test. Results. There were 17 subjects with II genotypes (53.1%), 14 subjects with ID genotypes (43.8%), and 1 subject with DD genotypes (3.1 %) in the CSFP group. While in the non-CSFP group, there were 11 subjects with II genotypes (34.4%), 13 subjects with ID genotypes (42.2%), and 9 subjects with DD genotypes (14.1%). The median value of angiotensin II levels in CSFP and Non-CSF group was 58 pg/mL and 32.8 pg/mL, respectively. The results of the analysis showed that there was an effect of angiotensin II levels on the incidence of CSFP (p=0.001). Further analysis showed that there was a correlation between angiotensin II levels and the I/D 287 bp alu repetitive sequence polymorphism in the intron 16 ACE gene (p=0.030, r=0.822). Conclusions. There was a correlation between I/D 287 bp alu repetitive sequence polymorphism in the intron 16 ACE gene and angiotensin II levels in the coronary slow flow phenomenon at Mohammad Hoesin General Hospital Palembang.
Reperfusion Arrhythmia in Acute Myocardial Infarction Setiadi, Teguh; Taufik Indrajaya; Ali Ghanie; Ferry Usnizar; Erwin Sukandi; Syamsu Indra; Erwin Azmar; Rukiah Chodilawati; Imran Soleh; Yudhie Tanta
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 12 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i12.894

Abstract

Management of reperfusion in acute myocardial infarction is an important component of myocardial cell survival to minimize the area experiencing infarction and improve patient clinical outcomes. However, this reperfusion also contributes to myocardial injury which is preceded by the ischemic process. One of the injuries related to the ischemia-reperfusion process in the myocardium is reperfusion arrhythmia. Reperfusion arrhythmias from several studies can begin to occur in the first minutes after restoration of obstructed coronary flow. The features of reperfusion arrhythmia can include accelerated idioventricular rhythm, ventricular tachycardia, ventricular fibrillation, and other arrhythmias. The mechanism of reperfusion arrhythmia can be excess calcium in the cells, oxidative stress due to an increase reactive oxygen species, energy metabolism disorders, and neutrophil accumulation. Excessive intracellular calcium and other mechanisms cause a delay in the depolarization of previously ischemic cells. This reperfusion arrhythmia requires special attention because it can disrupt hemodynamics and patient outcomes after reperfusion procedures. Knowledge of the mechanisms of reperfusion arrhythmias will guide clinicians to provide better management during and after reperfusion procedures.
Prevalensi anemia defisiensi besi pada tenaga kesehatan di Ruang Layanan Infeksi COVID-19 RSUD Sekayu, Kabupaten Musi Banyuasin Mediarty; Ghanie, Ali; Erty Sundarita; Reagan, Muhammad; Putra, Ahmad Khoirun; Istiqomah, Amelia; Haryadi, Muhammad; Zetira, Rizha; Puspalina, Ferda; Hermawan, Nandi
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 2 No 3 (2021): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V2I3.66

Abstract

Anemia is a medical problem that occurs throughout the world, especially in developing countries such as Indonesia. One type of anemia that is often asymptomatic (silent anemia) is iron deficiency anemia, which mostly occurs in the productive age group. This condition in addition to causing a decrease in work productivity also affects the body's immunity which is very important in the current state of the COVID-19 pandemic. The purpose of this activity was to determine the pattern of anemia and the prevalence of iron deficiency anemia in health workers who work in the COVID-19 infection service room who are at high risk for infection if they have a weak immune system. The results showed that 11 people (14.47%) of health workers had absolute or relative iron deficiency anemia. Although this figure is relatively lower than the national average, the management of this condition is very important because it is related to the services that will be provided to the community.
Co-Authors Erty Sundarita Erwin Azmar Erwin Sukandi Ferry Usnizar Ferry Usnizar, Ferry Haryadi, Muhammad Hermawan, Nandi Imran Soleh Indra, Syamsu Indrajaya, Taufik Istiqomah, Amelia Karlina, Arlis Mediarty Muhammad Reagan Puspalina, Ferda Putra, Ahmad Khoirun Rukiah Chodilawati Saleh, Imran Sukandi, Erwin Syamsu Indra Taufik Indrajaya Teguh Setiadi Yudhie Tanta Zetira, Rizha