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All Journal Biomedical Journal of Indonesia Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Pengabdian Masyarakat: Humanity and Medicine Jurnal Penyakit Dalam Indonesia Jurnal Lantera Ilmiah Pengabdian Masyarakat
Indrajaya, Taufik
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Veterinary

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FACTORS AFFECTING THICKENING OF CAROTID INTIMA MEDIA THICKNESS IN PATIENTS WITH CHRONIC KIDNEY DISEASE Yonata, Ade; Ali, Zulkhair; Indrajaya, Taufik; Effendi, Ian; Suhaimi, Novadian
Biomedical Journal of Indonesia Vol 6, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i1.10539

Abstract

Chronic kidney disease (CKD) is associated with high mortality rates related to cardiovascular complications. Atherosclerosis, arteriosclerosis and vascular calcification conditions are often found in CKD patients. Carotid intima media thickness (cIMT) thickening is one of the parameters of vascular disorders. A cross sectional study was conducted on patients with chronic kidney disease in the hospital. Mohammad Hoesin Palembang. Patients' blood samples were examined in the hospital laboratory. CIMT thickening was examined using echocardiography. A total of 55 patients with stage 3-5 chronic kidney disease were examined. The median cIMT is 0.8 (0.6-1.45) mm. Spearman's correlation analysis showed a significant correlation between triglyceride levels and thickening of cIMT (r = 0.303, p = 0.025). A significant correlation was also shown between phosphate levels and cIMT thickening (r = 0.290, p = 0.032). There is a significant correlation of triglyceride levels and phosphate levels to cIMT thickening in patients with chronic kidney disease in Palembang
CORRELATION OF SERUM SCLEROSTIN LEVELS WITH CAROTID INTIMA MEDIA THICKNESS IN CHRONIC KIDNEY DISEASE HEMODIALYSIS Permana, Adhi; Effendi, Ian; Indrajaya, Taufik
Biomedical Journal of Indonesia Vol 6, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i1.10185

Abstract

Chronic kidney disease is associated with a high mortality rate, especially cardiovascular disease associated with mineral and bone disorders. Sclerostin is an inhibitor of Wnt signaling which has the effect of increasing the occurrence of vascular calcification in patients with chronic kidney disease. There are several studies that show different results. Carotid intima media thickness ultrasound examination is a tool to identify atherosclerosis which is part of vascular calcification. The aim of this study is to look at the correlation of sclerostin with carotid intima media thickness (CIMT) in patients with chronic kidney disease undergoing hemodialysis. In this cross section, the concentration of sclerostin was measured by examination of enzymed linked immunosorbent assay. CIMT measurement by ultrasound mode B examination. There were 40 patients in this study. The mean sclerostin level was 256.68 ± 127.76 pg / ml. Sclerostin levels are declared high if above 162 pg / ml there are 30 people. CIMT thickening was present in 11 patients. There was no significant correlation of serum sclerostin with CIMT in patients with chronic kidney disease undergoing hemodialysis (r-0.32 p0,847). In multivariate linear regression, hemodialysis duration is an independent factor that is significantly significant with CIMT. There was no significant correlation of serum sclerostin with CIMT in patients with chronic kidney disease undergoing hemodialysis.
Role of IL-6 and IGF-1 in sarcopenia Riviati, Nur; Legiran, Legiran; Indrajaya, Taufik; Saleh, Irsan
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 1: March 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2023.303 KB) | DOI: 10.30604/jika.v8i1.1625

Abstract

Background: Sarcopenia is a syndrome characterized by decreased muscle mass and decreased muscle strength and muscle function. Oxidative stress and inflammatory processes are known to contribute to sarcopenia by releasing the catabolic stimuli interleukin-6 (IL-6) and insulin-like growth factor (IGF). Methods: The method used is a literature review by collecting appropriate articles from the PubMed and Google Scholar databases. Results: Low IL-6 can trigger satellite cell activity and myotube regeneration, whereas if IL-6 production increases chronically, it triggers muscle wasting. Changes in muscle size are the result of changes in the synthesis and degradation of muscle protein. IGF-1, where signal changes are strongly related to muscle size. IGF-1 binding to the receptor causes intracellular phosphorylation of the adapter protein Shc or insulin receptor substrate (IRS-1). Conclusion: The role of IGF-1 and IL-6 can be helpful as diagnostic and prognostic parameters for sarcopenia. Abstrak: Latar belakang: Sarkopenia adalah sindrom yang ditandai dengan penurunan massa otot disertai penurunan kekuatan otot dan atau fungsi otot. Stres oksidatif dan proses inflamasi dikenal sebagai faktor pemicu untuk sarkopenia dengan melepaskan rangsangan katabolik interleukin-6 (IL-6) dan IGF1. Metode: Metode yang digunakan adalah literature review dengan mengumpulkan artikel-artikel yang sesuai dari data base PubMed dan google sholar. Hasil: IL-6 yang rendah dapat mencetuskan aktivitas sel-sel satelit dan regenerasi myotube, sedangkan bila produksi IL-6 meningkat secara kronik mencetuskan muscle wasting. Perubahan ukuran otot merupakan dampak dari perubahan sintesis dan degradasi protein otot. IGF-1 dimana perubahan sinyal berhubungan kuat dengan ukuran otot. Ikatan IGF-1 pada reseptor menyebabkan fosforilasi intracellular adaptor proteins Shc atau insulin receptor substrate (IRS-1). Kesimpulan: Peran IGF-1 dan IL-6 dapat berguna sebagai parameter diagnostik dan prognostic terhadap kejadian sarcopenia.
Correlation between Parathyroid Hormone Serum Levels andAbdominal Aortic Calcification in Chronic Hemodialysis Patientsat Dr. Mohammad Hoesin Center General Hospital Palembang Akbar, M Yusuf Arief; Ali, Zulkhair; Indrajaya, Taufik; Suhaimi, Novadian; Devi, SNA Ratnasari; Bahar, Erial
Jurnal Penyakit Dalam Indonesia Vol. 8, No. 1
Publisher : UI Scholars Hub

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Abstract

Introduction. Cardiovascular disease is the most common cause of death in patients with chronic kidney disease (CKD). This is evidenced by the finding of vascular calcification in CKD patients. The process of vascular calcification that occurs is often associated with secondary hyperparathyroid conditions that are complications of CKD patients. The aim of this study was to asses the relationship between serum PTH levels and the abdominal aorta calcification (AAC) in CKD patients undergoing hemodialysis (HD) Methods. This observational analytic study with cross-sectional correlation test was conducted in the internal medicine ward of dr. Mohammad Hoesin Palembang from July to December 2019. Subjects were patients who had undergone HD >3 months with age >18 years. All subjects were examined for serum PTH levels and measured the carotid artery wall using doppler ultrasonography and the degree of calcification of the abdominal aorta using a lateral lumbar X-ray which was calculated using the Kauppila score. Results. There were 86 of HD patients studied, 65 subjects (75.6%) had high serum PTH levels and 46 subjects (53.5%) who had AAC. The Spearman correlation analysis showed that serum PTH levels had a relationship with Kauppila score (p=0.014, r=0.264). Multivariate linear regression analysis obtained age (p<0.001, r=0.510), duration of HD (p=0.020, r=0.256), history of hypertension (p=0.031, r=0.239) and serum phosphate levels (p=0.011, r=0.281) had a relationship to the Kauppila score. Conclusions. There is a significant relationship between serum PTH levels and AAC in chronic HD patients. The presence of factors including age, duration of HD, hypertension, and serum phosphate levels also affect the incidence of AAC
The Effect of Angiotensin-Converting Enzyme GenePolymorphism and Angiotensin II Levels in Coronary SlowFlow Phenomenon at Mohammad Hoesin General HospitalPalembang Karlina, Arlis; Indrajaya, Taufik; Ghanie, Ali; Sukandi, Erwin; Usnizar, Ferry; Indra, Syamsu; Chodilawati, Rukiah; Saleh, Imran
Jurnal Penyakit Dalam Indonesia Vol. 8, No. 2
Publisher : UI Scholars Hub

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Abstract

Introduction. The presence of ACE gene polymorphism is expected to have a role in cardiovascular diseases, including coronary slow flow phenomenon (CSFP). Angiotensin converting enzyme (ACE) gene polymorphism also plays an essential role in increasing angiotensin II levels. Therefore, this study aimed to analyze the effect of angiotensin-converting enzyme gene polymorphism and angiotensin II levels in the coronary slow flow phenomenon in Mohammad Hoesin General Hospital Palembang. Methods. This case-control study was started from July 2019 to July 2020 at RSMH Palembang with 32 subjects for each case (CSFP patients) and the control group (non-CSF patients). This study used a pair of primers and onetimed PCR to detect ACE gene polymorphism. Genetic analysis was carried out in the Biotechnology Laboratory Faculty of Medicine, Universitas Sriwijaya. Statistical analysis was performed using the Spearman correlation test. Results. There were 17 subjects with II genotypes (53.1%), 14 subjects with ID genotypes (43.8%), and 1 subject with DD genotypes (3.1 %) in the CSFP group. While in the non-CSFP group, there were 11 subjects with II genotypes (34.4%), 13 subjects with ID genotypes (42.2%), and 9 subjects with DD genotypes (14.1%). The median value of angiotensin II levels in CSFP and Non-CSF group was 58 pg/mL and 32.8 pg/mL, respectively. The results of the analysis showed that there was an effect of angiotensin II levels on the incidence of CSFP (p=0.001). Further analysis showed that there was a correlation between angiotensin II levels and the I/D 287 bp alu repetitive sequence polymorphism in the intron 16 ACE gene (p=0.030, r=0.822). Conclusions. There was a correlation between I/D 287 bp alu repetitive sequence polymorphism in the intron 16 ACE gene and angiotensin II levels in the coronary slow flow phenomenon at Mohammad Hoesin General Hospital Palembang.
Depresi, Ansietas, dan Komplikasi Pasca Sindrom Koroner Akut Indrajaya, Taufik
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 4
Publisher : UI Scholars Hub

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Abstract

Faktor risiko dan gejala osteoporosis pada komunitas dewasa di Desa Ibul Besar Pemulutan Ogan Ilir Sumatera Selatan Umi Partan, Radiyati; Reagan, Muhammad; Hermansyah, Hermansyah; Darma, Surya; Muthia, Putri; Mediarty, Mediarty; Indrajaya, Taufik; Kurniati, Nova; Riviati, Nur; Yuniza, Yuniza
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 2 No 3 (2021): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V2I3.68

Abstract

. Osteoporosis is a worldwide health issue. The microarchitecture of the bone is deteriorating, which increases the risk of fracture and disability. As the Indonesian people's life expectancy increases, the incidence of osteoporosis rises, making it more difficult to manage. This community service is carried out as a form of preventive treatment in the adult community in the village of Ibul Besar III Pemulutan Ogan Ilir, South Sumatra, which is one of Sriwijaya University's guided villages, with counseling methods to increase knowledge and health checks for early detection of osteoporosis, as well as calcium supplementation. There were 81 participants in this activity, with numerous dominant risk factors for osteoporosis identified, including female gender, menopausal state, and age above 50. Musculoskeletal symptoms, such as pain in the waist and back, which can be a consequence of osteoporosis, are more common than non-musculoskeletal symptoms.
Penyuluhan Perilaku Hidup Bersih dan Sehat Pada Siswa/i SD N 1 Abab Kabupaten Pali Afdhal, Fitri; Oktasari, Indriyani; Loren, Sefti; Selvi; Septiana; Sismayanti; Yuliawati, Suci; Marissa, Miki; Ilyas, Widya Putri; Sintha Patari, Vira; Agustiani, Nabila Tri; Ramadani, Utari; Yansyah, Welly; Yuliarti, Sindi; Oktapiani, Pebi; Wiratama, Made Dwi; Indrajaya, Taufik
JURNAL LENTERA ILMIAH PENGABDIAN MASYARAKAT Vol. 2 No. 1 (2025): JLIPM - APRIL
Publisher : CV. Q2 Lantera Ilmiah Institut

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Abstract

Perilaku Hidup Bersih dan Sehat (PHBS) merupakan salah satu upaya preventif dalam meningkatkan kualitas kesehatan masyarakat, terutama di lingkungan sekolah. Kurangnya kesadaran siswa dalam menerapkan PHBS dapat meningkatkan risiko penyakit infeksi seperti diare dan ISPA. Kegiatan pengabdian ini bertujuan untuk meningkatkan pemahaman dan praktik PHBS pada siswa SD N 1 Abab melalui metode edukatif yang interaktif dan berbasis praktik langsung. Penyuluhan dilakukan dengan metode ceramah, demonstrasi praktik mencuci tangan, serta evaluasi pre-test dan post-test untuk mengukur efektivitas program. Hasil evaluasi menunjukkan adanya peningkatan signifikan dalam perilaku hidup sehat siswa, di mana kebiasaan mencuci tangan meningkat dari 50% menjadi 85%, pola makan sehat dari 67% menjadi 90%, dan kunjungan ke posyandu dari 50% menjadi 78%. Dengan hasil ini, dapat disimpulkan bahwa penyuluhan berbasis praktik langsung dan interaktif efektif dalam meningkatkan kesadaran dan perilaku hidup sehat siswa. Keberlanjutan program ini dapat ditingkatkan dengan pemantauan berkala, dukungan aktif dari tenaga pendidik, serta pemanfaatan media digital sebagai sarana edukasi tambahan
Faktor-Faktor yang Berhubungan dengan Massa Otot, Kekuatan Otot, dan Performa Fisik pada Lansia Riviati, Nur; Indrajaya, Taufik; Chodilawati, Rukiah; Dibyantari, Ridzqie; Indra, Bima
Jurnal Penyakit Dalam Indonesia
Publisher : UI Scholars Hub

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Abstract

Introduction. Despite its high prevalence and significant impact on health, comprehensive studies are still needed to explore the factors affecting sarcopenia parameters, such as muscle mass, muscle strength, and physical performance. This study aimed to identify the factors influencing sarcopenia parameters in the elderly, including muscle mass, muscle strength, and physical performance. Methods. A cross-sectional study was conducted from July to December 2022 on elderly individuals (>60 years old) at the Geriatric Polyclinic, Moh. Hoesin General Hospital, Palembang, selected through consecutive sampling. Muscle mass was measured using bioimpedance analysis, expressed in ASMI values; muscle strength was measured using a handheld dynamometer; and physical performance was assessed using the five-time sit-to-stand test. The SARC-F score was classified as normal (<4) and abnormal (≥4). Data on age, gender, serum albumin levels, comorbidities, and Mini Nutritional Assessment Short Form (MNA-SF) scores were collected for correlation analysis and comparison with muscle mass, muscle strength, and physical performance. Results. Of the 41 subjects, the average age was 70.75 (SD 7) years, with 56.1% being female. All subjects had low muscle mass, with an average ASMI of 3.31 (SD 0.59) kg/m² in females and 4.89 (SD 1.06) kg/m² in males. The average muscle strength for females was 16.9 (SD 6.1) kg and for males 27.5 (SD 8.3) kg. The five-time sit-to-stand test result for females was 24.2 (SD 14.2) seconds and for males, 21.8 (SD 11.1) seconds. Based on SARC-F, 8 subjects (19.5%) were categorized as at risk for sarcopenia. Serum albumin levels for all subjects were within the normal range [4.3 (SD 0.3) g/dl]. Malnutrition was found in 14 subjects (34.1%) according to the MNA-SF results. Comorbidities were present in 35 patients. Statistical analysis showed a significant correlation between serum albumin levels and muscle strength (r=0.35; p=0.005) and physical performance (r=-0.5; p<0.001). Nutritional status had no significant effect on the three parameters, but it did significantly affect muscle mass in elderly males (p=0.002). Comorbidities, including cardiovascular disease, non-insulin-dependent diabetes mellitus, and musculoskeletal disorders, were not significantly related to any of the sarcopenia parameters. Conclusions. Serum albumin is significantly associated with muscle strength and physical performance, while nutritional status is significantly associated with muscle mass in elderly males. Comorbidities were not significantly related to muscle mass, muscle strength, or physical performance in the elderly.
Co-Authors Ade Yonata, Ade Agustiani, Nabila Tri Akbar, M Yusuf Arief Ali Ghanie Devi, SNA Ratnasari Dibyantari, Ridzqie Effendi, Ian Erial Bahar, Erial Ferry Usnizar, Ferry FITRI AFDHAL Hermansyah Hermansyah Ilyas, Widya Putri Indra, Bima Indra, Syamsu Karlina, Arlis kurniati, nova Legiran Legiran Loren, Sefti Marissa, Miki Mediarty, Mediarty Muhammad Irsan Saleh Muhammad Reagan Muthia, Putri Nur Riviati, Nur Oktapiani, Pebi Oktasari, Indriyani Permana, Adhi Ramadani, Utari Rukiah Chodilawati Saleh, Imran Selvi Septiana Sintha Patari, Vira Sismayanti Suhaimi, Novadian Sukandi, Erwin Surya Darma Umi Partan, Radiyati Wiratama, Made Dwi Yansyah, Welly Yuliarti, Sindi Yuliawati, Suci Yuniza, Yuniza Zulkhair Ali