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All Journal Jurnal Penyakit Dalam Indonesia
Ferry Usnizar, Ferry
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Medicine & Pharmacology

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The Effect of Angiotensin-Converting Enzyme GenePolymorphism and Angiotensin II Levels in Coronary SlowFlow Phenomenon at Mohammad Hoesin General HospitalPalembang Karlina, Arlis; Indrajaya, Taufik; Ghanie, Ali; Sukandi, Erwin; Usnizar, Ferry; Indra, Syamsu; Chodilawati, Rukiah; Saleh, Imran
Jurnal Penyakit Dalam Indonesia Vol. 8, No. 2
Publisher : UI Scholars Hub

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Introduction. The presence of ACE gene polymorphism is expected to have a role in cardiovascular diseases, including coronary slow flow phenomenon (CSFP). Angiotensin converting enzyme (ACE) gene polymorphism also plays an essential role in increasing angiotensin II levels. Therefore, this study aimed to analyze the effect of angiotensin-converting enzyme gene polymorphism and angiotensin II levels in the coronary slow flow phenomenon in Mohammad Hoesin General Hospital Palembang. Methods. This case-control study was started from July 2019 to July 2020 at RSMH Palembang with 32 subjects for each case (CSFP patients) and the control group (non-CSF patients). This study used a pair of primers and onetimed PCR to detect ACE gene polymorphism. Genetic analysis was carried out in the Biotechnology Laboratory Faculty of Medicine, Universitas Sriwijaya. Statistical analysis was performed using the Spearman correlation test. Results. There were 17 subjects with II genotypes (53.1%), 14 subjects with ID genotypes (43.8%), and 1 subject with DD genotypes (3.1 %) in the CSFP group. While in the non-CSFP group, there were 11 subjects with II genotypes (34.4%), 13 subjects with ID genotypes (42.2%), and 9 subjects with DD genotypes (14.1%). The median value of angiotensin II levels in CSFP and Non-CSF group was 58 pg/mL and 32.8 pg/mL, respectively. The results of the analysis showed that there was an effect of angiotensin II levels on the incidence of CSFP (p=0.001). Further analysis showed that there was a correlation between angiotensin II levels and the I/D 287 bp alu repetitive sequence polymorphism in the intron 16 ACE gene (p=0.030, r=0.822). Conclusions. There was a correlation between I/D 287 bp alu repetitive sequence polymorphism in the intron 16 ACE gene and angiotensin II levels in the coronary slow flow phenomenon at Mohammad Hoesin General Hospital Palembang.
Profil Biomarker Apolipoprotein B dan Lipid terhadap Skor SYNTAX pada Pasien Sindrom Koroner Kronik Chalik, Muhammad Novran; Sukandi, Erwin; Indrajaya, Taufik; Usnizar, Ferry; Indra, Syamsu; Saleh, Imran; Chodilawati, Rukiah; Irfannuddin, Irfannuddin
Jurnal Penyakit Dalam Indonesia
Publisher : UI Scholars Hub

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Introduction. Apolipoproteins are structural components of plasma lipoproteins that are involved in lipoprotein metabolism and lipid transport, reflecting the number of circulating atherogenic particles. The degree of coronary artery stenosis can be assessed by calculating the Synergy between PCI with TAXUS/paclitaxel-eluting stent and Cardiac Surgery (SYNTAX) score, which is an angiographic scoring system used to evaluate the complexity of coronary artery lesions. This study aimed to investigate the profile of apolipoprotein B and lipids, as well as their correlation with the SYNTAX score in patients with chronic coronary syndrome. Methods. An observational analytic study with a cross-sectional design was conducted from July to September 2024 in the cardiac catheterization laboratory of the Department of Internal Medicine, Mohammad Hoesin General Hospital, Palembang. A total of 69 samples were obtained using consecutive sampling. Samples that met the inclusion and exclusion criteria were analyzed using SPSS version 22. Data were presented in tables and figures. Data analysis was performed using correlation tests with a significance level of p < 0.05. This study received ethical approval from the Ethics Committee of Dr. Mohammad Hoesin General Hospital, Palembang. Results. Among the 34 analyzed subjects, the mean total cholesterol, LDL cholesterol, and apolipoprotein B levels were 175.88 (SD 36.01) mg/dL, 123.59 (SD 35.54) mg/dL, and 141.41 (SD 25.06) mg/dL, respectively. HDL cholesterol and triglyceride levels were not normally distributed and were therefore expressed as medians (range): 42 (29–80) mg/dL and 89 (40–289) mg/dL, respectively. The mean SYNTAX score was 24.09 (SD 2.69). Overall, 20.59% of subjects had a SYNTAX score Conclusions. Patients with chronic coronary syndrome demonstrated elevated apolipoprotein B levels and high SYNTAX scores. Higher apolipoprotein B levels were independently and positively associated with the SYNTAX score. Further studies are needed to investigate additional factors influencing apolipoprotein B levels, lipid profiles, and the SYNTAX score.
Co-Authors Ali Ghanie Chalik, Muhammad Novran Indra, Syamsu Indrajaya, Taufik Irfannuddin Irfannuddin Karlina, Arlis Rukiah Chodilawati Saleh, Imran Sukandi, Erwin