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All Journal Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Ners
Niaga, Karmenia Jessica Kurnia
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Humanities Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Social Sciences Other

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Peran Mikrobiota Saluran Cerna pada Artritis Reumatoid Tjahyanto, Teddy; Eldy, Eldy; Felicia, Clarissa; Niaga, Karmenia Jessica Kurnia
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : CV. Ridwan Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (602.799 KB) | DOI: 10.36418/syntax-literate.v6i11.4568

Abstract

Artritis rheumatoid merupakan suatu penyakit autoimun yang ditandai dengan adanya proses inflamasi kronis sistemik dan berakibat pada kerusakan sendi. Mekanisme etiopatogenik yang menyebabkan inflamasi yang sangat kompleks dan melibatkan berbagai faktor, termasuk keseimbangan mikrobiota saluran cerna. Tujuan penelitian dilakukan untuk meninjau lebih dalam mengenai peran interaksi inang-mikrobiota terhadap sistem kekebalan inang, mendiskusikan kemungkinan hubungan patofisiologi antara disbiosis mikrobiota saluran cerna dan manifestasi, serta menyarankan langkah preventif dan terapi potensial untuk artritis rheumatoid melalui perbaikan disbiosis mikrobiota saluran cerna. Sumber literatur diambil dari artikel jurnal yang dipublikasikan secara online dalam rentang waktu tahun 2016-2021. Database yang digunakan adalah PubMed, Science Direct, Cochrane, dan Wiley. Penelitian menunjukkan adanya korelasi yang kuat antara disbiosis dan inflamasi mukosa saluran cerna dengan patogenesis artritis reumatoid. Disbiosis mikrobiota saluran cerna menyebabkan terbentuknya imunotoleransi yang berakibat pada penyakit autoimun. Peran mikrobiota pada artritis rheumatoid meliputi produksi sitokin proinflamasi dan sel Th17, serta pembentukan autoantibodi ACPA. Metabolit anti inflamasi mikrobiota seperti butirat yang meregulasi keseimbangan TFH/TFR didapatkan menurun pada artritis reumatoid. Disbiosis mikrobiota saluran cerna telah terbukti menjadi salah satu faktor penting dalam manifestasi artritis rheumatoid pada model hewan. Studi tambahan perlu dilakukan untuk mengeksplorasi keterlibatan mikrobiota dalam saluran cerna yang berbeda dalam modulasi imun selama patogenesis artritis reumatoid.
Characteristics And Risk Factors of Post-Vaccination Covid-19 on Indonesian Adults: A Cross-Sectional Study Niaga, Karmenia Jessica Kurnia; Martin, Alfianto
Jurnal Ners Vol. 8 No. 1 (2024): APRIL 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v8i1.23231

Abstract

The COVID-19 pandemic has prompted various countries to carry out vaccinations as an effort to limit its spread. Despite the distribution of vaccines, COVID-19 cases are still being reported. This study aims to identify the risk factors that influence the occurrence and severity of post-vaccination COVID-19 in Indonesian citizens and describe its characteristics. This descriptive study was conducted from January to March 2022 using cross-sectional research design. The study population comprised of Indonesian citizens who have received COVID-19 vaccines and were infected afterwards. Data were collected through online questionnaires. Participants were classified based on the number and types of vaccine received and severity of manifestation. Of 623 Indonesian citizens, 111 (18%) experienced post-vaccination COVID-19. Mild symptoms were found in 72% participants and 12% participants were asymptomatic. The most common manifestation was anosmia (72%), followed by fever (55%). The entire participants with moderate and severe symptoms received the inactivated virus vaccine. Severe manifestations were found in participants with overweight or obesity, diabetes, heart disease, and autoimmune disease. Third dose of vaccination was related to mild or no symptoms. Our study recommends an administration of additional doses especially for at-risk populations. Keywords: COVID-19, Vaccines, Clinical Manifestation, Indonesia, Comorbidity
Co-Authors Eldy, Eldy Felicia, Clarissa Martin, Alfianto Tjahyanto, Teddy