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Achmad Taher
Jurusan Kimia-FMIPA Universitas Negeri Papua Manokwari-Papua Barat
Agriculture, Biological Sciences & Forestry Chemistry Mathematics Physics

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Karakterisasi Nukleotida Daerah Ekson 5 dan 6 Gen LDLR Penduduk Papua Hamida; Achmad Taher
Jurnal Natural Vol. 15 No. 1 (2019): Jurnal Natural
Publisher : FMIPA Universitas Papua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30862/jn.v15i1.26

Abstract

The diversity shown in tribes in Papua has the potential to produce varying genetic diversity. LDLR gene is a gene coding for LDL receptor proteins (LDL-R) that play a very important role in cholesterol homeostasis. The LDLR gene consists of 18 exons and 17 introns that stretch for 45 kilos of base (kb). . The exon 5 and 6 regions are important structural parts in encoding amino acids and are also ligand binding regions that mediate the interaction between receptors and lipoproteins containing Apo B-100 or Apo E. This study aims to characterize the nucleotides of Papuan populations with different origins. The method used is the polymorphism chain reaction method and sequencing method to find out the sequence of nucleotide bases. The results of the exon 5 and 6 regional nucleotide characterization of LDLR genes from 9 UNIPA students from Papua showed identical results because they had the same number of nucleotides and nucleotide arrangements. The number of nucleotides for exon 5 area is 123 pb, consisting of T = 22.0%, C = 24.4%, G = 30.9%, A = 22.8%, A + T = 44.8% and C + G = 55.3%. For exon 6 area with nucleotide amount of 123 pb, the nucleotide composition is T = 16.3%, C = 26.8%, G = 27.6%, A = 29.3%, A + T = 45.6% and C + G = 54.4%. The same results show that the two regions are conserved.
SNP PADA GEN KEMOKIN C-C MOTIF LIGAN 7 (CCL7) PENDERITA STROKE DI KABUPATEN MANOKWARI Muti Dornita Simamora; Muhammad Fajar Islam; Achmad Taher
Jurnal Natural Vol. 19 No. 2 (2023): Jurnal Natural
Publisher : FMIPA Universitas Papua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30862/jn.v19i2.245

Abstract

Chemokines are key components in the development of chronic disease. Chemokine C-C motif ligan 7 (CCL7) is one of the chemokines believed to be associated with the pathology of atherosclerosis that causes stroke. CCL7 may play a role in inflammatory events by attracting macrophages and moncytes to further amplify inflammatory processes and contribute to atherosclerosis progression. Common Genetic variation in CCL7 gene has been associated with atherosclerosis progress, so the main objective of this study was identification of polymorphism of CCL7 gene in stroke patients. Five blood samples were taken from five patients suffering from stroke. The DNA of the blood samples were extracted, amplified its CCL7 gene, and sequenced. The results showed a sequence of 1151 bp consisting of regulator, exon 1, intron and exon 2. One polymorphic sites were found in the intron 1 region, at position 1447. The SNP genotype identified was TC.
Co-Authors DEWI APRI ASTUTI Dondin Sajuthi Hamida Muhammad Fajar Islam Muti Dornita Simamora SULISTIYANI SULISTIYANI TARUNI SRI PRAWAST MIEN KAOMINI ANY ARYANI DEDY DURYADI SOLIHIN