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All Journal Jurnal Pembangunan Wilayah dan Kota Althea Medical Journal Jurnal Farmasi Klinik Indonesia Jurnal Pengabdian Masyarakat : Pemberdayaan, Inovasi dan Perubahan Folia Medica Indonesiana
Afiati Afiati
Departemen Patologi Anatomi Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Dr. Hasan Sadikin Bandung
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Journal : Althea Medical Journal

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Hepatoprotective Effect of Solanum melongena/Eggplant against Acute Hepatitis Komara, Nabhan; Sastramihardja, Herri S.; Afiati, Afiati
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Althea Medical Journal

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   Background: Hepatitis is a liver inflammation that can be acute or chronic and may cause damage to hepatocytes such as necrosis.. Hepatocyte necrosis can be inhibited by antioxidants such as flavonoids found in Solanum melongena fruit. This study aimed to determine the hepatoprotective effect of Solanum melongena fruit infusion to inhibit hepatocytes damage in CCl4-induced rats.Methods: Twenty five male Wistar rats were randomly divided into five groups, and adapted for 7 days before the experimental study. Negative and positive groups were given aquadest, Group III−V were given Solanum melongena fruit infusion containing 1.125 grams, 2.25 grams and 4.5 grams orally for 9 days. At the 9th day, all rats were induced by 8 mL/kgBW of 10% CCl4 in paraffin, except for the negative group. Rats were sacrificed on the 11th day, and liver biopsy preparations were made. Hepatocyte necrosis was counted and was analyzed by Kruskal-Wallis test and Mann-Whitney test. Results: The study showed that the percentage of necrotic hepatocytes in group III, IV a nd V were lower than in the positive group. Using Mann-Whitney test, there were significant differences in negative group, group III, and group V (p<0.05). Meanwhile, unsignificant difference was seen between the positive group and group IV (p>0.05). Kruskal-Wallis test showed that there weresignificantly differences among groups (p<0.05). Conclusions: Solanum melongena fruit infusion has hepatoprotective effects against acute hepatitis in rat model histopathologically.Keywords: CCl4, flavonoids, hepatocyte, necrosis, Solanum melongena DOI: 10.15850/amj.v2n1.434  
Characteristics of Liposarcoma Patients: 5-Year Data Rahmah, Miftahur; Afiati, Afiati; Sugiri, Unwati
Althea Medical Journal Vol 5, No 1 (2018)
Publisher : Althea Medical Journal

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Background: Liposarcoma is the second highest soft tissue sarcoma in adults with prevalence of 15% to 25%. If the size of liposarcoma is very large, it may cause abdominal pain, weight loss, gastrointestinal bleeding, even kidney failure. Therefore, for early detection of liposarcoma, the characteristics of liposarcoma should be investigated. This study aimed to determine liposarcoma characteristics based on age, sex, location and histopathologic type according to WHO (World Health Organization) Classification of Tumors 2013.Methods: A descriptive study was conducted from August to October 2015 at the Department of Anatomic Pathology, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. Data was obtained from database of patients with liposarcoma at the Department of Anatomic Pathology in the period of January 2010 to December 2014. The collected data was presented in the form of figures and tables.Results: Out of 102 cases, the percentage of liposarcoma was highest between the age of 50 and 59 years (31.37%), followed by the age of 40–49 years (28.43%). The percentage were slightly higher in males (54.9%) compared to females with a ratio of 1.22:1. Femur (23.52%), intraabdomen (22.55%) and retroperitoneum (11.76%) were the most common locations affected. The most common histopathologic subtype was myxoid liposarcoma (52.95%) exceeding a half of the total cases.Conclusions: Liposarcoma most likely occurs in the age range of 40–60 years, the percentage is slightly higher in males, and abdomen and lower extremities are the most common location affected. Myxoid liposarcoma is the most common subtype. 
Co-Authors Aulia, Yatasya Bethy S. Hernowo Bethy Suryawathy Hernowo Birgitta M. Dewayani, Birgitta M. Darmawan, Nabilah Yahdiani Dewi, Mira Dyani Dinariansyah, Faradilla Azzahra Ernady Syaodih Firmansyah, Mochammad Agus Gina Puspitasari Rochman Hasanah, Afni Nur Hermin Aminah Usman Herri S. Sastramihardja Meike Rachmawati Nabhan Komara, Nabhan Nurhidayat, Ade Apon Nurwenda, Sartika Rahmah, Miftahur Rahmat, Reyiena Kusumaryani Riswandha Risang Aji Rizky Suganda Prawiradilaga Sabirin, Muhammad Syah Misuari Sugiri, Unwati