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All Journal Jurnal Pembangunan Wilayah dan Kota Althea Medical Journal Folia Medica Indonesiana Jurnal Farmasi Klinik Indonesia
Afiati Afiati
Departemen Patologi Anatomi Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Dr. Hasan Sadikin Bandung
Civil Engineering, Building, Construction & Architecture Medicine & Pharmacology Other

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Hepatoprotective Effect of Solanum melongena/Eggplant against Acute Hepatitis Komara, Nabhan; Sastramihardja, Herri S.; Afiati, Afiati
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Althea Medical Journal

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Abstract

   Background: Hepatitis is a liver inflammation that can be acute or chronic and may cause damage to hepatocytes such as necrosis.. Hepatocyte necrosis can be inhibited by antioxidants such as flavonoids found in Solanum melongena fruit. This study aimed to determine the hepatoprotective effect of Solanum melongena fruit infusion to inhibit hepatocytes damage in CCl4-induced rats.Methods: Twenty five male Wistar rats were randomly divided into five groups, and adapted for 7 days before the experimental study. Negative and positive groups were given aquadest, Group III−V were given Solanum melongena fruit infusion containing 1.125 grams, 2.25 grams and 4.5 grams orally for 9 days. At the 9th day, all rats were induced by 8 mL/kgBW of 10% CCl4 in paraffin, except for the negative group. Rats were sacrificed on the 11th day, and liver biopsy preparations were made. Hepatocyte necrosis was counted and was analyzed by Kruskal-Wallis test and Mann-Whitney test. Results: The study showed that the percentage of necrotic hepatocytes in group III, IV a nd V were lower than in the positive group. Using Mann-Whitney test, there were significant differences in negative group, group III, and group V (p<0.05). Meanwhile, unsignificant difference was seen between the positive group and group IV (p>0.05). Kruskal-Wallis test showed that there weresignificantly differences among groups (p<0.05). Conclusions: Solanum melongena fruit infusion has hepatoprotective effects against acute hepatitis in rat model histopathologically.Keywords: CCl4, flavonoids, hepatocyte, necrosis, Solanum melongena DOI: 10.15850/amj.v2n1.434  
Ekspresi Negatif Melanoma Cell Adhesion Molecule (MCAM) Berkorelasi dengan Metastasis Kelenjar Getah Bening Aksila pada Triple Negative Breast Cancer Nurwenda, Sartika; Dewayani, Birgitta M.; Afiati, Afiati; Hernowo, Bethy S.
Indonesian Journal of Clinical Pharmacy Vol 5, No 3 (2016)
Publisher : Indonesian Journal of Clinical Pharmacy

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  Triple negative breast cancer (TNBC) adalah karsinoma payudara yang memiliki ekspresi negatif untuk estrogen receptor (ER), progesteron receptor (PR), dan Human Epidermal Growth Factor Receptor (HER2). TNBC memiliki sifat agresif, frekwensi metastasis ke Kelenjar Getah Bening (KGB) aksila yang tinggi, prognosis yang buruk, dan rekurensi yang tinggi. Metastasis ke KGB aksila akan mempengaruhi angka kesintasan hidup dan angka rekurensi penderita TNBC. Melanoma cell adhesion molecule (MCAM) adalah membran glikoprotein dari superfamili imunoglobulin, yang terlibat di dalam ikatan antar sel, yang kemudian dikenal sebagai marker untuk progresi dan metastasis melanoma dan karsinoma prostat. Namun, peran MCAM pada karsinoma mammae masih kontroversial. Tujuan penelitian ini untuk menilai korelasi ekspresi MCAM dengan metastasis ke KGB aksila pada TNBC. Penelitian ini dilaksanakan pada periode 1 Januari 2010–31 April 2015 di laboratorium Patologi Anatomi Fakultas Kedokteran, Universitas Padjadjaran. Penelitian ini dilakukan menggunakan desain potong lintang analisis korelasi dengan menggunakan uji korelasi lambda. Pewarnaan imunohistokimia MCAM dilakukan terhadap 56 sampel blok parafin dari kelompok TNBC yang tidak bermetastasis dan telah bemetastasis ke KGB aksila. Sebanyak 22 dari 28 (78,6%) orang TNBC yang telah bermetastasis ke KGB aksila memiliki nilai histoskor MCAM <4 (negatif), sebaliknya 16 dari 28 (57,1%) orang TNBC yang tidak bermetastasis ke KGB aksila memiliki nilai histoskor ≥4 (positif). Ketiadaan ekspresi MCAM berkorelasi dengan metastasis TNBC ke KGB aksila, namun bukan satu-satunya faktor penentu metastasis.Kata kunci: KGB, metastasis, MCAM, triple negative breast cancer Negative Expression of Melanoma Cell Adhesion Molecule (MCAM) Correlated with Axillary Lymph Node Metastasis in Triple Negative Breast Cancer Triple negative breast cancer (TNBC) is breast cancers that demonstrate the absence of oestrogen receptor, progesterone receptor and human epidermal growth factor receptor 2. TNBC has an aggressive behaviour, high frequency of metastases to the axillary lymph nodes and recurrence, and poor prognosis. Metastasis to the axillary lymph nodes will affect the rate of survival and recurrence in TNBC. Melanoma cell adhession molecule (MCAM) is a membrane glycoprotein of the immunoglobulin superfamily, which is involved in the cells binding, which later became known as the marker for the progression and metastasis of melanoma and carcinoma of the prostate. However, MCAM role in mammary carcinoma still kontroversial. The aim of this study was to assess correlation between MCAM expression with incidence of metastatic to axillary lymph nodes in TNBC. This research was conducted during January 1st 2010–April 31st 2015 at Pathology Anatomy, Faculty of Medicine, Universitas Padjadjaran. This study used a cross-sectional design, using lambda correlation test. MCAM immunohistochemical staining performed on 56 samples of paraffin blocks of TNBC group that did not metastasized and has metastasized to the axillary lymph nodes. A total of 22 of 28 (78.6%) of TNBC metastatic to axillary lymph nodes have histoskor MCAM value <4 (negative), whereas 16 of 28 (57.1%) of TNBC non metastatic have histoskor value ≥ 4 (positive). Negative expression of MCAM correlated with TNBC that had metastasized to axillary lymph nodes, although not the only factor that influenced them.Keywords: Lymph node, metastasis, MCAM, triple negative breast cancer
Characteristics of Liposarcoma Patients: 5-Year Data Rahmah, Miftahur; Afiati, Afiati; Sugiri, Unwati
Althea Medical Journal Vol 5, No 1 (2018)
Publisher : Althea Medical Journal

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Abstract

Background: Liposarcoma is the second highest soft tissue sarcoma in adults with prevalence of 15% to 25%. If the size of liposarcoma is very large, it may cause abdominal pain, weight loss, gastrointestinal bleeding, even kidney failure. Therefore, for early detection of liposarcoma, the characteristics of liposarcoma should be investigated. This study aimed to determine liposarcoma characteristics based on age, sex, location and histopathologic type according to WHO (World Health Organization) Classification of Tumors 2013.Methods: A descriptive study was conducted from August to October 2015 at the Department of Anatomic Pathology, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. Data was obtained from database of patients with liposarcoma at the Department of Anatomic Pathology in the period of January 2010 to December 2014. The collected data was presented in the form of figures and tables.Results: Out of 102 cases, the percentage of liposarcoma was highest between the age of 50 and 59 years (31.37%), followed by the age of 40–49 years (28.43%). The percentage were slightly higher in males (54.9%) compared to females with a ratio of 1.22:1. Femur (23.52%), intraabdomen (22.55%) and retroperitoneum (11.76%) were the most common locations affected. The most common histopathologic subtype was myxoid liposarcoma (52.95%) exceeding a half of the total cases.Conclusions: Liposarcoma most likely occurs in the age range of 40–60 years, the percentage is slightly higher in males, and abdomen and lower extremities are the most common location affected. Myxoid liposarcoma is the most common subtype. 
Pariwisata Ramah Disabilitas: Praktik di Kota Bandung dan Sekitarnya Rochman, Gina Puspitasari; Afiati, Afiati; Aji, Riswandha Risang; Syaodih, Ernady
Jurnal Pembangunan Wilayah dan Kota Vol 19, No 1 (2023): JPWK Volume 19 No. 1 March 2023
Publisher : Universitas Diponegoro, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/pwk.v19i1.40640

Abstract

Indonesia memiliki banyak destinasi wisata dan penyandang disabilitas kerap menghadapi keterbatasan akses berwisata. Studi empiris mengenai pariwisata ramah disabilitas juga masih terbatas di Indonesia. Studi ini bertujuan mengindentifikasi sejauh mana praktik pariwisata ramah disabilitas di Kota Bandung, Kabupaten Bandung Barat, dan Kabupaten Bandung. Ketiga wilayah ini memiliki ragam wisata, seperti wisata alam, wisata budaya, agrowisata, dan wisata belanja.  Studi ini menggunakan pendekatan penelitian kualitatif dan metode analisis isi terhadap hasil wawancara, dokumen, hasil studi dan regulasi terkait. Sebanyak 15 informan kunci diwawancara dan 10 destinasi wisata di tiga wilayah tersebut diobservasi. Pariwisata ramah disabilitas menekankan aksesibilitas terhadap atraksi wisata sehingga penyandang disabilitas dapat memenuhi kebutuhan dan tujuannya berwisata tanpa khawatir. Studi ini berfokus pada eksplorasi penerapan wisata ramah dengan menekankan pada faktor atraksi, aksesibilitas, fasilitas pendukung, dan layanan tambahan.  Studi ini menyimpulkan bahwa sebagian besar destinasi wisata di Kota Bandung dan sekitarnya belum ramah disabilitas. Fasilitas dan layanan masih bersifat universal dan beberapa diantaranya memudahkan disabilitas berwisata, seperti tersedianya jalur pedestrian dan pintu masuk yang lebar. Namun, klasifikasi raba dengar, jalur pemandu, kepekaan terhadap disabilitas dan keterampilan komunikasi dari pekerja wisata, dan media visual interaktif belum tersedia. Pengelola wisata dan kebijakan yang dikeluarkan pemerintah daerah belum memperhatikan kebutuhan fasilitas dan layanan berdasarkan tipe disabilitas yang mana membutuhkan fasilitas dan layanan yang berbeda dalam berwisata.
The Role of Cyclin D1 and VEGF in Radiotherapy Response of Advance Stage Undifferentiated Nasopharyngeal Carcinoma Nurhidayat, Ade Apon; Afiati, Afiati; Usman, Hermin Aminah; Hernowo, Bethy Suryawathy
Folia Medica Indonesiana Vol. 56 No. 4 (2020): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1619.919 KB) | DOI: 10.20473/fmi.v56i4.24554

Abstract

Nasopharyngeal carcinoma has a high incidence and mortality rate in Southeast Asia and Indonesia. Radioresistance is a major obstacle to successful treatment of nasopharyngeal carcinoma. DNA repair in the cell cycle and angiogenesis factors affects the response of tumor cells to radiotherapy. Cyclin D1 that functions in the cell cycle process and VEGF as an angiogenesis factor are considered to play a role in the occurrence of radioresistance. The objective of this study is to find the association between immunoexpression of Cyclin D1 and VEGF with radiotherapy response in undifferentiated nasopharyngeal carcinoma. This study used a retrospective case control analysis design, secondary data from medical records of patients diagnosed as undifferentiated nasopharyngeal carcinoma who received complete radiotherapy at the Radiation Oncology Department  Dr Hasan Sadikin Bandung were taken. There were 44 samples divided into radiosensitive (22 samples) and radioresistant (22 samples) groups. Immunohistochemical examination of Cyclin D1 and VEGF was performed on paraffin blocks of patients' biopsy. Data analysis using Chi-Square test (p ≤0.05) , OR 95% CI. Cyclin D1 expressed strongly in 86.4% of the radioresistant group and 59.1% in the radiosensitive group (p<0.05) and the OR 4,385 (0.993-19.356), VEGF was strongly expressed in 77.3% of the radioresistant group and 54.5% in the radiosensitive group (p>0.05). As conclusion, there were significant association between Cyclin D1 with radiotherapy respons in undifferentiated nasopharyngeal carcinoma. The stronger immunoexpression of Cyclin D1, the higher likelihood of radioresistancy. VEGF immunoexpression showed no significant association with radiotherapy response.
Co-Authors Bethy S. Hernowo Bethy Suryawathy Hernowo Birgitta M. Dewayani, Birgitta M. Ernady Syaodih Gina Puspitasari Rochman Hermin Aminah Usman Herri S. Sastramihardja Nabhan Komara, Nabhan Nurhidayat, Ade Apon Nurwenda, Sartika Rahmah, Miftahur Riswandha Risang Aji Sugiri, Unwati