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The Reduction of Oxidative Stress in Dyslipidemic Sprague Dawley Rats with Exposure to Mulberry Leaf Extract and Simvastatin Purnama, Yugi Hari Chandra; Fifin Luthfia Rahmi; Banundari Rachmawati
Jurnal Kesehatan dr. Soebandi Vol 12 No 1 (2024): Jurnal Kesehatan dr. Soebandi
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jkds.v12i1.575

Abstract

Dyslipidemia induces oxidative stress, leading to the subendothelial accumulation of atherogenic lipoproteins and the initiation of reactive oxygen species (ROS) formation. Secondary metabolites such as flavonoids found in mulberry leaves can act as antioxidants, suppressing the production of free radicals responsible for oxidative stress. This study aims to evaluate the impact of mulberry leaf extract and simvastatins on MDA levels in dyslipidemic Sprague Dawley rats. This research is a true experimental type with a pre-post test with control group design. The samples in this study were mulberry leaves and Sprague Dawley rats. Mulberry leaves were extracted using the maceration method with 70% ethanol solvent, then continued with antioxidant testing using DPPH. The number of samples in this study was 30 male rats which were divided into 5 groups; group P1 (HFD + mulberry leaf extract), P2 (HFD + simvastatin), P3 (HFD + mulberry leaf extract + simvastatin) as well as the normal group and the negative control group. Mulberry leaf ethanol extract has an IC50 value of 5.61 ppm which is very strong category. The intervention was carried out for 8 weeks. MDA levels were checked before and after intervention. The results showed a significant decrease in MDA levels in treatment groups P1, P2 and P3. Changes in MDA levels between groups were tested using one way ANOVA with significant results p=0.000 (p < 0,05). Administration of mulberry leaf extract which is rich in flavonoids and simvastatin significantly reduces MDA levels in the blood of rats.
KEMAMPUAN PENDOKUMENTASIAN ASUHAN KEPERAWATAN OLEH MAHASISWA PROFESI NERS BERDASARKAN PENGETAHUAN 3S (SDKI, SLKI, SIKI) DI UNIVERSITAS DR.SOEBANDI JEMBER Purnama, Yugi hari Chandra; Astutik, Emy Eliya; Yuwanto, Mahmud Ady; Rosiana , Lutfiani
Jurnal Keperawatan Sriwijaya Vol. 10 No. 1 (2023): Vol 10, No 1 (2023)
Publisher : Bagian Keperawatan Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jks.v10i1.169

Abstract

Dokumentasi keperawatan merupakan kegiatan pencatatan dari semua aktifitas yang berkaitan dengan pemberian proses keperawatan bagi kepentingan klien, perawat dan mitra kerja. Perawat dalam melakukan dokumentasi keperawatan masih perlu di evaluasi, karena terdapat keragaman dan kesalahan dalam melakukan dokumentasi keperawatan. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan dokumentasi keperawatan berdasarkan 3S (SDKI, SLKI, SIKI) dengan kemampuan penerapan asuhan keperawatan pada mahasiswa ners di Universitas dr.Soebandi Jember. Desain penelitian ini adalah desain korelasional dengan pendekatan cross sectional. Populasi penelitian ini adalah mahasiswa profesi ners berjumlah 108 mahasiswa dan sampel yang diambil 35 mahasiswa, dengan menggunakan teknik Simple random sampling. Hasil penelitian menunjukkan bahwa ada hubungan antara pengetahuan dokumentasi keperawatan berdasarkan 3S dengan kemampuan penerapan asuhan keperawatan pada mahasiswa ners di UDS dengan signifikasi 0,000 (p < 0,05). Dalam meningkatkan kemampuan penerapan dokumentasi asuhan keperawatan berdasarkan 3S, maka dilakukan usaha dalam meningkatkan pengetahuan dokumentasi asuhan keperawatan secara baik dan benar. Kata kunci: Asuhan Keperawatan, Dokumentasi, Pengetahuan
IMPLEMENTASI KEPERAWATAN KOMPLEMENTER BEKAM PADA PENDERITA HIPERTENSI DI DESA CURAH KALONG KECAMATAN BANGSALSARI KABUPATEN JEMBER Purnama, Yugi Hari Chandra; Lailil Fatkuriyah
Jurnal SADEWA Vol 1 No 02 (2023): Sadewa: Jurnal Pengabdian Masyarakat
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/js.v1i02.498

Abstract

Hypertension is a non-communicable disease that is currently on the rise and is a disease of the blood vessels. Treatment of hypertension can be done pharmacologically or non-pharmacologically. The purpose of this community service is to introduce and implement it in the community in Curah Kalong Village, especially for people with hypertension. This community service activity includes the preparation, process, and evaluation stages. Participants were divided into three groups: people with hypertension, people with a history of hypertension, and the general public. This activity was carried out on March 2–3 2019 until it was finished at the Curah Kalong Village Hall, Bangsalsari District, Jember. Based on the results, there were 49 peoples who attended, with around 67% women (32 people) and the remaining 33% men (17 people). The results show that giving cupping complementary nursing therapy (average) can reduce systolic and diastolic blood pressure in hypertensive patients. The people of Curah kalong Village are enthusiastic about the socialization and implementation of cupping complementary nursing so that the benefits can be felt directly
IDENTIFICATION OF BIOACTIVE COMPOUNDS IN BUTTER AVOCADO PEEL EXTRACT (Persea americana) AS A POTENTIAL MEDICINAL RAW MATERIAL Purnama, Yugi Hari Chandra; Huda, Khumairoh Khaerani
International Journal of Islamic and Complementary Medicine Vol. 6 No. 2 (2025): International Journal of Islamic and Complementary Medicine
Publisher : International Islamic Medicine Forum

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55116/IJICM.V6I2.114

Abstract

Indonesia is rich in biodiversity, including various plant species with potential medicinal properties. Onesuch plant is the avocado (Persea americana), whose peel—often discarded as waste—contains bioactivecompounds of pharmacological interest. This study aimed to identify the secondary metabolites present in the ethanol extract of Butter Avocado peel from Jember, Indonesia, through qualitative phytochemicalscreening. The research involved the preparation of simplicia, extraction using 96% ethanol via maceration, and phytochemical testing for four major compound groups: alkaloids, flavonoids, tannins, and saponins. The results showed positive reactions for all tested compounds, indicating the presence of these metabolites. Alkaloids were detected through precipitate formation with Dragendorff’s reagent, flavonoids through color change with HCl and magnesium powder, tannins via a color reaction with FeCl₃, and saponins through persistent foam formation after shaking in hot water. The results of this study indicated that avocado skin contained natural compounds that had the potential to serve as alternative raw materials in the development of traditional medicines and phytopharmaceuticals.   ABSTRAKIndonesia merupakan negara yang kaya akan keanekaragaman hayati, termasuk berbagai spesies tanaman yang berpotensi sebagai obat. Salah satu tanaman tersebut adalah alpukat (Persea americana), di mana bagian kulit buahnya yang sering dianggap limbah ternyata mengandung senyawa bioaktif dengan manfaat farmakologis. Penelitian ini bertujuan untuk mengidentifikasi senyawa metabolit sekunder yang terdapat dalam ekstrak etanol kulit buah alpukat varietas mentega asal Jember, Indonesia, melalui uji fitokimia secara kualitatif. Proses penelitian meliputi pembuatan simplisia, ekstraksi menggunakan etanol 96% dengan metode maserasi, serta uji fitokimia terhadap empat golongan senyawa, yaitu alkaloid, flavonoid, tanin, dan saponin. Hasil menunjukkan reaksi positif terhadap keempat senyawa tersebut. Alkaloid terdeteksi melalui pembentukan endapan dengan reagen Dragendorff, flavonoid melalui perubahan warna setelah penambahan HCl dan serbuk magnesium, tanin melalui perubahan warna setelah ditambahkan FeCl₃, dan saponin melalui pembentukan busa stabil setelah dikocok dengan air panas. Hasil penelitian ini menunjukkan bahwa kulit buah alpukat mengandung senyawa alami yang berpotensi sebagai sebagai bahan baku alternatif dalam pengembangan obat tradisional dan fitofarmaka. 
THE RELATION BETWEEN NURSE THERAPEUTIC COMMUNICATION WITH PATIENT SATISFACTION AT JATIROTO PUSKESMAS, LUMAJANG Umi Kulsum, Siti; Purnama, Yugi Hari Chandra; Atik Maryati, Syska
International Journal of Islamic and Complementary Medicine Vol. 3 No. 1 (2022): International Journal of Islamic and Complementary Medicine
Publisher : International Islamic Medicine Forum

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55116/IJICM.V3I1.25

Abstract

Therapeutic Communication is defined as nurses communication techniques to provide support and information to patients aims to therapy. When the nurses provide good communication, it will bind a good relation between nurses and patient so that the patient will be satisfied with the services. This research aims to determine the relation between nurse therapeutic communication with inpatient satisfaction at Jatiroto publich health centre, Lumajang. This research was using correlational design with cross sectional approach. The sampling method was using incidental sampling and sampling technique was using nonprobability sampling. The data collection was conducted by observational and questionnaires. The result of this research shows that 73,3% nurse therapeutic communication are in good category and 26,7% nurse therapeutic communication are in passably category. The satisfaction level of patient 53,3% are satisfied, 13,3% are unsatisfied and 53,3% are very unsatisfied. The statistic analytical by Spearmean Rank was obtained p value 0.046 <0.05, it means there is a relation between nurse therapeutic communication with inpatient satisfaction at Jatirotopublich health centre, Lumajang.It means that the better nurse's therapeutic communication is, the more satisfied the patient is. Nurse's therapeutic communication is in good category and patient satisfaction is in satisfied category. The practice of health services through therapeutic communication by nurses at the Puskesmas is an example and a small part of the lessons and application of Akhlaq in a profession.
THE RELATIONSHIP BETWEEN LIFESTYLE AND THE INCIDENCE OF HYPERTENSION AT PRIMA HEALTH CENTER IN GUDANG VILLAGE SITUBONDO Soleha, Rinta Amaliatus; Basri, Achmad Ali; Wildan, Moh; Purnama, Yugi Hari Chandra
Journal of Nursing Periodic Vol. 2 No. 2 (2025): July
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction: Hypertension commonly occurs in middle-aged to elderly individuals and, if left untreated, can lead to fatal outcomes. It is often triggered by lifestyle factors such as physical inactivity, poor diet, lack of sleep, and smoking. Purpose: This study aimed to examine the relationship between lifestyle and the incidence of hypertension at the Prima Health Center in Gudang Village, Situbondo Regency. Methods: A cross-sectional correlational design was used. The study population consisted of 130 individuals, with a sample of 98 hypertensive patients selected through stratified sampling. Data were collected using a lifestyle questionnaire and observation sheet. Univariate analysis was conducted using frequency and percentage, while bivariate analysis used the Spearman rank test. Results: The majority (62.3%) of respondents had unhealthy lifestyles, and most (58.2%) were diagnosed with stage one hypertension. The Spearman rank test showed a p-value of 0.001 ≤ 0.05, indicating a significant correlation. The contingency coefficient of 0.538 suggests a moderate relationship between lifestyle and hypertension. Conclusion: Unhealthy lifestyles are associated with higher stages of hypertension. A significant correlation exists between lifestyle and the incidence of hypertension in Gudang Village
Efektivitas Pemberian Air Rebusan Kayu Manis Terhadap Perubahan Nyeri pada Remaja Putri yang Mengalami Dismenorea Maulidiya Rizkiyah; Purnama, Yugi Hari Chandra
Indonesian Journal of Nursing Research (IJNR) Vol. 8 No. 2 (2025)
Publisher : Program Studi S1 Keperawatan Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ijnr.v8i2.4589

Abstract

Dysmenorrhea results from elevated prostaglandin levels during menstruation and is frequently associated with symptoms such as back pain, nausea, fatigue, and headaches. Non-pharmacological approaches, including cinnamon consumption, may help alleviate these symptoms. This study was conducted to determine the effect of cinnamon tea on pain severity in adolescents with dysmenorrhea. This study used a pre-experimental design with a pretest-posttest design. The study involved 34 female students from SMAN 1 Mumbulsari who experienced dysmenorrhea, selected using accidental sampling over a one-month period. The intervention consisted of administering cinnamon decoction. Pain intensity was measured using the NRS. Data were analyzed using the Wilcoxon signed-rank test to compare pre- and post-intervention numeric pain scales. The findings demonstrated a significant reduction in pain intensity following the administration of cinnamon decoction, with a mean pain scale decreased from 6.29 to 1.50. (p < 0.05). This result indicates that cinnamon decoction effectively alleviates menstrual pain in adolescents with dysmenorrhea. Consumption of cinnamon decoction has been demonstrated to alleviate menstrual pain among female students at SMAN 1 Mumbulsari. This outcome is associated with the bioactive constituents of cinnamon, which possess anti-inflammatory and analgesic effects.   Abstrak Dismenorea muncul akibat peningkatan produksi hormon prostaglandin selama menstruasi. Sebagian besar perempuan melaporkan bahwa nyeri haid sering disertai gejala lain, seperti nyeri punggung, mual, kelelahan, dan sakit kepala. Penatalaksanaan dismenorea dapat dilakukan melalui metode nonfarmakologis, salah satunya dengan pemberian air rebusan kayu manis. Penelitian ini bertujuan menilai efektivitas air rebusan kayu manis terhadap perubahan tingkat nyeri pada remaja putri dengan dismenorea. Studi ini menggunakan desain pra-eksperimen dengan pendekatan pretest–posttest. Populasi pada penelitian ini yaitu siswi SMAN 1 Mumbulsari yang mengalami disminorea dan teknik sampling yang digunakan yaitu accidental sampling yang mana didapatkan 34 responden selama satu bulan. Penelitian ini menggunakan dua variabel, yaitu pemberian air rebusan kayu manis dan perubahan intensitas nyeri. Instrumen yang digunakan adalah lembar observasi nyeri dengan Numeric Rating Scale (NRS). Analisis data dilakukan menggunakan uji Wilcoxon. Hasil penelitian menunjukkan adanya perbedaan signifikan antara sebelum dan sesudah intervensi, dengan penurunan rata-rata skala nyeri dari 6,29 menjadi 1,50 (p < 0,05). Pemberian air rebusan kayu manis terbukti dapat mengurangi keluhan nyeri menstruasi pada siswi SMA 1 Mumbulsari. Efek tersebut terkait dengan kandungan senyawa aktif dalam kayu manis yang memiliki sifat antiinflamasi dan analgesik.