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All Journal Cermin Dunia Kedokteran The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Zulkifly, Steven
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Health Professions Medicine & Pharmacology Public Health

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Manfaat Kopi untuk Mencegah Penyakit Alzheimer Zulkifly, Steven; Darmawan, Irene; Tambunan, Victor
Cermin Dunia Kedokteran Vol 44, No 10 (2017): Pediatrik
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1306.83 KB) | DOI: 10.55175/cdk.v44i10.721

Abstract

Penyakit Alzheimer merupakan penyakit neurodegeneratif yang menimbulkan gangguan kognitif, memori, bahasa, perilaku dan visuospasial sehingga dapat menurunkan kualitas hidup penderitanya. Prevalensi penyakit ini meningkat seiring meningkatnya usia yaitu 5%-10% pada usia 65 tahun menjadi 30%-40% pada usia di atas 85 tahun. Hingga saat ini, penyakit Alzheimer belum dapat disembuhkan. Kopi sehari-hari dikonsumsi masyarakat. Zat aktif pada kopi yaitu kafein diketahui berperan sebagai antagonis reseptor A2A dan penghambatan produksi β-Amiloid, yang merupakan salah satu patologi penyakit Alzheimer. Konsumsi kopi sekitar 3-5 cangkir per hari dapat menurunkan risiko Alzheimer.Alzheimer’s Disease is a neurodegenerative disease with cognitive impairment, memory disturbance, language, behaviour and visuospatial deficits. Its prevalence increases with age; 5%-10% at age 65 to 30%-40% at age 85 and over. Until now, there is no effective treatment for this disease. Coffee is a popular beverage widely consumed by people in the world. Literature reviews showed that caffeine, an active substance in coffee, acts asA2A receptor antagonists and inhibits production of β-Amyloid, which is one of the pathology of Alzheimer's disease. Three to five cups of coffee a day may decrease the risk of Alzheimer’s disease. 
Selective Serotonin Reuptake Inhibitors and Risk of Gastrointesinal Bleeding In Dyspepsia: An Evidence-Based Case Report Shatri, Hamzah; Zulkifly, Steven; Putranto, Rudi; Makmun, Dadang; Fauzi, Achmad; Maulahela, Hasan; Faisal, Edward; Irvianita, Vinandia; Ardani, Yanuar
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 2 (2023): VOLUME 24, NUMBER 2, August, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2422023182-191

Abstract

Aim: This evidence-based case report aims to provide the latest evidence about the risk of gastrointesinal (GI) bleeding in selective serotonin reuptake inhibitor (SSRI) users with dyspepsia.Method: The literature search was conducted in four major electronic databases (PubMed, Cochrane, Scopus, ProQuest). The selected articles were sorted through screening abstract based on the inclusion and exclusion criteria. Critical appraisal was performed by using validated critical appraisal tool.Results: Of 247 records from extensive literature searching, three eligible studies (one randomized clinical trial and two cohort studies) were obtained to answer the clinical question. All studies showed SSRIs did not increase the risk of GI bleeding in patients with functional dyspepsia and peptic ulcer. However, the adverse event of SSRIs might be under-reported.Conclusion: According to the evidence, the risk of GI bleeding in SSRIs users with dyspepsia is still unclear. Larger size of sample of controlled trial study is recommended to be conducted to calculate the precise risk of GI bleeding in SSRI users with dyspepsia.
Non-Cirrhotic Portal Hypertension: An Update of Diagnosis and Management Zulkifly, Steven; Hasan, Irsan
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 2 (2023): VOLUME 24, NUMBER 2, August, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2422023143-153

Abstract

Portal hypertension is not the only caused by liver cirrhosis. Non-cirrhotic portal hypertension (NCPH) is characterized by elevated portal pressure in the absence of cirrhosis and is often underdiagnosed in daily clinical practice. The clinical manifestations of NCPH are similar to liver cirrhosis. The diagnosis of NCPH is still challenging due to the various underlying etiologies and often require either non-invasive or invasive examination. Laboratory examination, abdominal ultrasound, endoscopic procedure, hepatic venous gradient measurement, and liver biopsy have role in diagnosis of NCPH. The principle management of NCPH is to treat portal hypertension and its complications, such as prophylaxis and acute management of variceal bleeding, anticoagulants, surgery, splenectomy, and liver transplantation.
Co-Authors Achmad Fauzi Ardani, Yanuar Dadang Makmun Darmawan, Irene E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Faisal, Edward Hasan Maulahela, Hasan Irsan Hasan Irvianita, Vinandia Rudi Putranto Victor Tambunan