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All Journal Cermin Dunia Kedokteran eJournal Kedokteran Indonesia Journal of General-Procedural Dermatology & Venereology Indonesia
Darmawan, Irene
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Manfaat Kopi untuk Mencegah Penyakit Alzheimer Zulkifly, Steven; Darmawan, Irene; Tambunan, Victor
Cermin Dunia Kedokteran Vol 44, No 10 (2017): Pediatrik
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1306.83 KB) | DOI: 10.55175/cdk.v44i10.721

Abstract

Penyakit Alzheimer merupakan penyakit neurodegeneratif yang menimbulkan gangguan kognitif, memori, bahasa, perilaku dan visuospasial sehingga dapat menurunkan kualitas hidup penderitanya. Prevalensi penyakit ini meningkat seiring meningkatnya usia yaitu 5%-10% pada usia 65 tahun menjadi 30%-40% pada usia di atas 85 tahun. Hingga saat ini, penyakit Alzheimer belum dapat disembuhkan. Kopi sehari-hari dikonsumsi masyarakat. Zat aktif pada kopi yaitu kafein diketahui berperan sebagai antagonis reseptor A2A dan penghambatan produksi β-Amiloid, yang merupakan salah satu patologi penyakit Alzheimer. Konsumsi kopi sekitar 3-5 cangkir per hari dapat menurunkan risiko Alzheimer.Alzheimer’s Disease is a neurodegenerative disease with cognitive impairment, memory disturbance, language, behaviour and visuospatial deficits. Its prevalence increases with age; 5%-10% at age 65 to 30%-40% at age 85 and over. Until now, there is no effective treatment for this disease. Coffee is a popular beverage widely consumed by people in the world. Literature reviews showed that caffeine, an active substance in coffee, acts asA2A receptor antagonists and inhibits production of β-Amyloid, which is one of the pathology of Alzheimer's disease. Three to five cups of coffee a day may decrease the risk of Alzheimer’s disease. 
User acceptance of DeSkab mobile application for early detection of scabies in Indonesia Widaty, Sandra; Friska, Dewi; Bramono, Kusmarinah; Sari, Siti Maulidya; Darmawan, Irene; Kekalih, Aria
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 7, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: Individual case management strategy is not suitable for reducing scabies transmission, especially in high prevalence settings. A community-based approach has been proposed to control scabies. We developed a mobile application, called DeSkab, to empower non-medical personnel in crowded populations e.g., boarding schools, and to aid the identification of skin lesions suggesting scabies based on the cardinal signs of scabies. Early treatment and prevention of scabies transmission is expected to follow this approach. This was the initial development of the DeSkab mobile application which aims to assess user acceptance. Methods: The DeSkab mobile application was designed using Java and XML, supported by Google's Android. The scabies detection and education features were the app’s key distinctive aspects. An online survey was performed, aimed at potential users, including boarding school teachers and healthcare workers. The survey was divided into four sections: application design and user-friendliness, early detection data entry and interpretation, education features, and user recommendations. Result: Overall, users' acceptance of this application was good. More than 70% of the users gave good feedback for the application. Using mobile health makes it easier for the users to find information about scabies and check whether their skin lesions are suggestive of scabies. Conclusion: This application is expected to help expand scabies detection, especially in crowded communities. Improvements must be made to the interface, data entry, and educational material for the app's next iteration. Further study is needed to determine how mobile health application can improve scabies detection in communities.
Empowering nonmedical personnel to detect scabies in endemic area using DeSkab instrument: A diagnostic study Widaty, Sandra; Kekalih, Aria; Friska, Dewi; Bramono, Kusmarinah; Sari, Siti Maulidya; Darmawan, Irene; Sujudi, Yufanti; Hartanto, David Dwiadiputra; Kartika, Emiliana; Oktavia, Nikken Rima
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Scabies has been added to World Health Organization (WHO) list of neglected tropical disease in 2017. Various methods have been developed to control scabies in highly prevalent communities. In this study we conducted a diagnostic study to evaluate the performance of scabies detection by trained nonmedical personnel (NMP) using Deteksi Skabies (Deskab) instrument which has been validated for NMP. Methods: Eight NMPs in a boarding school were trained to detect scabies using DeSkab instrument. The NMPs diagnosis were compared to diagnosis of 10 medical doctors. The study was conducted in a religion-affiliated boarding school in West Java, Indonesia. Both examiners consecutively assessed boarding school students using DeSkab instrument and were blinded to each other findings. Results: Among 140 participants included in this study, scabies was confirmed by medical doctors in 60 participants. Diagnostic accuracy of NMPs examination is 72.14% [95% confidence interval (CI) 64.2-78.9], with sensitivity and specificity 67.42% (95% CI 57.13-76.26), and 80.32% (95% CI 67.54-88.98) respectively. The inter-rater agreement (Cohen’s kappa) for diagnosing scabies is 0.44. Conclusion: NMPs can be trained to detect scabies in their community with acceptable accuracy. Improving training are recommended to further improve the diagnosis skills and maintaining sustainable detection program.
Scabies Training for Improving Non-Medical Personnel Knowledge in High-Risk Population in Indonesia: Pelatihan Skabies untuk Meningkatkan Pengetahuan Tenaga Non-Medis pada Populasi Risiko Tinggi di Indonesia Widaty, Sandra; Kekalih, Aria; Bramono, Kusmarinah; Sari, Siti Maulidya; Darmawan, Irene; Dewi Friska
eJournal Kedokteran Indonesia Vol. 12 No. 3 (2024): Vol. 12 No. 3 - Desember 2024
Publisher : Faculty of Medicine Universitas Indonesia

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Abstract

Scabies elimination is always challenging, as treatment alone is not sufficient to stop the transmission. To stop the transmission in places such as boarding schools, a community-based approach and cooperation with the teacher and managerial team are important. This study aims to evaluate the effectiveness of scabies detection training for non-medical personnel (NMP) in improving knowledge about scabies. This cross-sectional study was conducted in an Islamic boarding school in Bogor. NMPs in boarding school were trained to detect and prevent scabies in their communities. The training consists of expert lectures, group discussions and simulation training. All the participants were required to fill out the pre-test and post-test questionnaires. In 60 participants, there was a significant improvement from pre-test to post-test scores (p<0.001), and 85% showed an improvement in post-test. The knowledge about scabies' symptoms and signs had the best improvement, while the knowledge improvement about the elimination of mites and scabies prevention was still poor after the training. The improvement of scabies knowledge after training was significant. Training models focused on NMP knowledge in recognizing scabies for early detection in the community have the potential to be used by collaboration of health practitioners and boarding school management to eradicate the scabies problem.
Co-Authors Aria Kekalih Dewi Friska Dewi Friska Hartanto, David Dwiadiputra Kartika, Emiliana Kusmarinah Bramono Oktavia, Nikken Rima Sandra Widaty Sari, Siti Maulidya Sujudi, Yufanti Victor Tambunan Zulkifly, Steven