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Yustin Ellista Sari, Endra
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Keratoakantoma Regio Gluteal Paramitasari, Anggana Rafika; Arrochman, Ferry; Dewi, Susanti Rosmala; Imelda Betaubun, Ance; Zulfikar, Dendy; Yustin Ellista Sari, Endra
Cermin Dunia Kedokteran Vol 46, No 5 (2019): Pediatri
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (680.871 KB) | DOI: 10.55175/cdk.v46i5.482

Abstract

Keratoakantoma (KA) adalah neoplasma jinak sel skuamosa yang jarang berkembang menjadi karsinoma dan bermetastasis. Keratoakantoma sering dijumpai pada daerah terpapar sinar matahari dan secara klinis sulit dibedakan dari karsinoma sel skuamosa (KSS). Walaupun jarang, KA dapat muncul di tempat yang tidak terpapar matahari. Kasus seorang wanita 59 tahun dengan benjolan di bokong sejak 15 tahun yang makin membesar. Pasien pernah dioperasi namun lesi muncul kembali. Hasil pemeriksaan fisik menunjukkan tumor soliter regio gluteal 2 x 2,5 x 0,5 cm sewarna kulit terfiksir, bagian inti berbentuk seperti kawah dengan tepi berbatas tegas. Dermoskopi menunjukkan gambaran massa keratin hitam kekuningan di tengah lesi, dengan zona berwarna keputihan dan struktur vaskuler berbentuk hairpin di sekitar lesi. Pemeriksaan histopatologi menunjukkan tumpukan massa keratin dan nekrotik yang mengarah ke diagnosis KA. Pasien diterapi dengan eksisi luas.Keratoacanthoma (KA) is a benign neoplasm usually found in sun-exposed body surface. It is rarely developed into metastatic carcinoma, but difficult to be distinguished with squamous cell carcinoma (SCC). Previous surgery, obesity, and scratching lead to chronic trauma in gluteal region can be rare risk factors. The case is a 59 year-old woman with tumour in buttock area for 15 years. The tumour was previously removed but reccurent. Physical examination shows fixed solitary tumor 2 x 2,5 x 0,5 cm, with central yellowish and hyperpigmentation mass. Dermoscopic examination reveals yellowish and black mass in the centre, whitish halo and hairpin vascular pattern around the lesion. Histopathologic examination results keratin mass in the epidermis consistent to KA. This patient was treated with wide excision. 
Metotreksat Intramuskular untuk Terapi Psoriasis Vulgaris: Serial Kasus Rafika Paramitasari, Anggana; Hartati, Agung Triana; Mustifah, Etty Farida; Yustin Ellista Sari, Endra; Kusumawardani, Arie
Cermin Dunia Kedokteran Vol 45, No 8 (2018): Alopesia
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (821.515 KB) | DOI: 10.55175/cdk.v45i8.627

Abstract

Metotreksat merupakan pilihan terapi psoriasis yang efektif. Laporan pemberian MTX parenteral pada psoriasis vulgaris masih jarang. Kami melaporkan 8 kasus psoriasis vulgaris dengan terapi injeksi MTX dosis inisial 10mg/minggu dan dinaikkan menjadi 15mg/minggu. Dalam evaluasi 8-12 minggu, terdapat perbaikan klinis yang dievaluasi menggunakan Psoriasis Activity and Severity Index (PASI), luas Body Surface Area (BSA) dan Dermatology Life Quality Index (DLQI). Bioavailabilitas MTX parenteral lebih baik dibandingkan peroral. Tidak ditemukan efek samping selama pemberian injeksi MTX.Methotrexate (MTX) is the commonly prescribed for psoriasis. Reports on parenteral MTX for psoriasis in Indonesia are still scarce. We reported eight psoriasis patients treated with intramuscular MTX 10mg/week increased to 15mg/week. The clinical improvement was remarkable demonstrated with Body Surface Area (BSA), Psoriasis Activity and Severity Index (PASI) and Dermatology Life Quality Index (DLQI) scores. Bioavailability of parenteral MTX is better than oral MTX. No adverse effect was found and the clinical improvement was good.
Hemangioma Verukosa Rinandari, Ummi; Yustin Ellista Sari, Endra
MEDICINUS Vol. 33 No. 3 (2020): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (338.125 KB) | DOI: 10.56951/medicinus.v33i3.62

Abstract

Verrucous hemangioma (VH) is a localized verrucous venous malformation comprising a capillary or cavernous hemangioma with proliferation reactions such as epidermal hyperkeratosis, acanthosis or papillomatosis also vascular proliferation and widening in the dermis to subcutaneous tissue. This disorder is usually found in the lower extremities and unilateral. It is often misdiagnosed as venous or lymphatic malformations. An 11 year-old boy presented with rough patches and blackish-red lumps on the right leg since birth. Four months prior, the lesion bled after being hit by ball and became rougher, thickened and darker thereafter. He was initially diagnosed with hemangioma and cryotherapy was performed, but there was no improvement after 6 cryotherapy treatment. A diagnosis of VH should be considered in the presence of erythematous papules, nodules, and plaques, especially those that are hyperkeratotic, present at birth, located at the lower extremities, and progressively enlarge after trauma or infection. Based on patient history, physical examination and laboratory results, the patient was diagnosed with VH. Excision surgery is the gold standard of VH management. The excision of the lesion must be deep and wide with a margin of 1 cm, to minimize recurrence. Treatment consists of combination of clobetasol propionate 0.05% and salicylic acid 5% ointment before excision was performed.
Co-Authors Arrochman, Ferry Dewi, Susanti Rosmala Hartati, Agung Triana Imelda Betaubun, Ance Kusumawardani, Arie Mustifah, Etty Farida Paramitasari, Anggana Rafika Rafika Paramitasari, Anggana Rinandari, Ummi Zulfikar, Dendy