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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Ners Open Access Indonesian Journal of Medical Reviews Cermin Dunia Kedokteran Journal of Social Research MEDICINUS Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia Plexus Medical Journal

Kusumawardani, Arie

Unknown Affiliation

Author-ID : 1976690

Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Terapi Probiotik (Lactococcus lactis) Topikal untuk Akne Vulgaris: Kasus Serial Anggraeni, Reti; Rosita, Fiska; Kusumawardani, Arie
Cermin Dunia Kedokteran Vol 48, No 1 (2021): Penyakit Dalam
Publisher : PT. Kalbe Farma Tbk.

Latar Belakang: Akne vulgaris (AV) adalah penyakit inflamasi kulit kronik yang mengenai unit pilosebasea, mengakibatkan kelainan non-inflamasi berupa komedo dan tanda inflamasi. Mikroba kulit seperti Propionibacterium acnes (P. acnes) dan Malassezia spp. berperan dalam patogenesis AV. Laporan kasus ini mengenai efek terapi probiotik topikal terhadap perbaikan lesi AV. Kasus: Tiga pasien AV diberi terapi tabir surya (SPF 30) dan probiotik topikal selama 4 minggu tanpa terapi standar AV. Pemeriksaan swab dilakukan pada semua pasien untuk melihat jenis dan jumlah mikrobiom. Hasilnya tidak ditemukan kolonisasi P. acnes tetapi terjadi penurunan jumlah dan derajat keparahan lesi pada semua pasien. Terapi yang sama dilanjutkan selama 4 minggu pada satu pasien. Kolonisasi P. acnes hanya ditemukan pada awal terapi. Evaluasi klinis yaitu penurunan jumlah lesi AV dan kulit wajah menjadi lebih halus dan lembap. Ringkasan: Probiotik topikal memberikan hasil baik pada kasus AV.Introduction: Acne vulgaris (AV) is chronic inflammatory skin disease affecting pilosebaceous unit, resulting in non-inflammatory disorders in the form of comedones and signs of inflammation. Skin microbes such as Propionibacterium acnes (P. acnes) and Malassezia spp. play role in the AV pathogenesis. This paper reports the effects of topical probiotic on AV lesions improvement. Case: Three AV patients were given sunscreen (SPF 30) and topical probiotics for 4 weeks without standard AV therapy. Swab examination showed no P. acnes colonization but the amount and severity of lesions in all patients were decreased. One patient then continued the same therapy for 4 weeks; P. acnes colonization was only found at the beginning of therapy. Clinical evaluation resulted in decreasing lesions and smoother and moisturized facial skin. Summary: Topical probiotic gives good results in AV.

Metotreksat Intramuskular untuk Terapi Psoriasis Vulgaris: Serial Kasus Rafika Paramitasari, Anggana; Hartati, Agung Triana; Mustifah, Etty Farida; Yustin Ellista Sari, Endra; Kusumawardani, Arie
Cermin Dunia Kedokteran Vol 45, No 8 (2018): Alopesia
Publisher : PT. Kalbe Farma Tbk.

Metotreksat merupakan pilihan terapi psoriasis yang efektif. Laporan pemberian MTX parenteral pada psoriasis vulgaris masih jarang. Kami melaporkan 8 kasus psoriasis vulgaris dengan terapi injeksi MTX dosis inisial 10mg/minggu dan dinaikkan menjadi 15mg/minggu. Dalam evaluasi 8-12 minggu, terdapat perbaikan klinis yang dievaluasi menggunakan Psoriasis Activity and Severity Index (PASI), luas Body Surface Area (BSA) dan Dermatology Life Quality Index (DLQI). Bioavailabilitas MTX parenteral lebih baik dibandingkan peroral. Tidak ditemukan efek samping selama pemberian injeksi MTX.Methotrexate (MTX) is the commonly prescribed for psoriasis. Reports on parenteral MTX for psoriasis in Indonesia are still scarce. We reported eight psoriasis patients treated with intramuscular MTX 10mg/week increased to 15mg/week. The clinical improvement was remarkable demonstrated with Body Surface Area (BSA), Psoriasis Activity and Severity Index (PASI) and Dermatology Life Quality Index (DLQI) scores. Bioavailability of parenteral MTX is better than oral MTX. No adverse effect was found and the clinical improvement was good.

Physical Stability Test of Ethanol Extract Cream of Bajakah Wood as Topical Antiaging Cream Prasetyorini, Budi Eko; Kusumawardani, Arie; Ellistasari, Endra Yustin
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

The barakah ethanolic extract (Spatholobus littoralis Hassk) contains antioxidants that function as antiaging. The use of barakah wood ethanolic extract cream as a cosmetic preparation requires a long preparation time, so it is necessary to formulate a preparation that is practical and durable in storage. Cream components affect the physical stability of the preparation. Physical stability tests need to be carried out to ensure the quality, safety, and benefits of the cream meet the expected specifications and are stable during storage. This study aims to make the physical stability of the formulation of the cream preparations of barakah wood ethanol extract at concentrations of 7.5%, 15%, and 30%. The design of this study was an experimental laboratory. The stability test was carried out using the cycling test method for 6 cycles by re-testing its physical properties. Physical evaluation includes organoleptic tests, homogeneity, pH, dispersion, and adhesion. Preparation of cream formula 7.5%, 15%, and 30% of the results of testing physical properties (cycle 0) namely organoleptic test (smell: typical of wood; color: dark brown; texture: semi-solid), homogenity (homogeneous arrangement), pH F1, 2 and 3 p = 0.524; 0.350 and 0.745 adhesion F1, 2 and 3 p = 0.209; 0.207 and 0.377 spreadability F1, 2 and 3: p = 0.690; 0.207 and 0.395 the results of statistical values in formula 1, 2 and 3 which show the value of Sig(2-tailed) where this value is p > 0.05 which means there is no significant difference before and after the cycling test. In the cream stability during the cycling test (cycles 1-6) there was no significant difference. There was no statistically significant difference in any physical evaluation of the cream stem ethanolic extract barakah 7.5%, 15%, and 30% so the three concentrations of cream were stable creams.

The Difference In Transepidermal Water Loss (TEWL) Values Between Sun-exposed and Non-sun-exposed Skin Among Male Medical Students Prihadi, Ihsany Arafiasetyanto; Ellistasari, Endra Yustin; Kusumawardani, Arie
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 6, No. 2
Publisher : UI Scholars Hub

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Background: Transepidermal Water Loss (TEWL) is the amount of water released from the human body into the atmosphere through a diffusion process per unit of time. Changes in TEWL indicate impaired skin barrier function. Exposure to ultraviolet light for an extended period can cause photoaging, characterized by rough and dry skin (xerosis cutis). TEWL will increase significantly in the skin exposed to ultraviolet radiation. This study aims to determine the difference in the TEWL values among male medical students in the sun-exposed and non-sun-exposed skin areas. Methods: An analytical observational cross-sectional study was conducted at the Dermatology and Venereology Department of RSUD Dr. Moewardi Surakarta in January-March 2021. Sampling was carried out through consecutive sampling and 25 samples were obtained. TEWL examination was performed on the dorsal area of the forearm and the medial area of the upper arm using the Tewameter TM300. The mean value of TEWL was analyzed using the non-parametric Wilcoxon signed rank test and Spearman's correlation test. Results: Based on the Wilcoxon signed rank test, there was a significant difference in the value of TEWL (p = 0.000). Spearman correlation analysis shows the coefficient value of r = 0.599, with p = 0.002. Conclusion: There is a significant difference in TEWL values in the sun-exposed skin area compared to the non-sun-exposed skin area, with a moderate positive correlation.

The relationship between increased body mass index with transepidermal water loss: a comparative study Yudhistira, Muhammad Yurizar; Kusumawardani, Arie; Widhiati, Suci; Mulianto, Nurachmat
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 6, No. 1
Publisher : UI Scholars Hub

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Background: Obesity affect significant populations on all ages. The relationship between obesity and metabolic diseases is known but a dermatological link is rarely explained. Transepidermal water loss (TEWL) is one of the measurement tools used to define the skin’s barrier function by measuring the amount of water that evaporates through the skin in aspecific amount of time. Although several studies on TEWL are available but discussion about the correlation between TEWL and body mass index (BMI) is still limited. This study aims to evaluate the correlation between TEWL and BMI. Methods: This research is a single-center study with analytical cross-sectional design that includes healthy subjects among medical students aged 18 to 23 years old in Universitas Sebelas Maret. A questionnaire was used to ensure that all subjects met the criteria. Chi-square and Pearson were used to analyze the observed variables.Results: The total sample in this study was 62 participants, with a majority of female (59.7%) and ranged from 21 to 23 years (74.2%). The ratio of normoweight and overweight/obese was 1:1. The results demonstrated significant difference and positive correlation between increased BMI with TEWL (pConclusion: This study showed a significant correlation between increased body mass index and transepidermal water loss. Overweight participants tend to develop high values of TEWL which reflect a disruption of skin barrier. Further research on other influencing factors with larger samples and more study centers are needed.

Discoid lupus erythematosus in an 8-year-old girl: A rare case Febriani, Dina; Kusumawardani, Arie; Widhiati, Suci
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 7, No. 1
Publisher : UI Scholars Hub

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Background: The occurrence of discoid lupus erythematosus in children is uncommon. The global prevalence of childhood-onset SLE (cSLE) varies between 3.3 and 8.8 cases per 100,000 children. The objective of this article was to present a case of DLE in a child, aiming to establish a diagnosis, provide suitable management, and consider the potential risk of developing SLE. Case Illustration: An 8-year-old girl visited the polyclinic at Dr. Moewardi General Hospital complaining of reddish spots, scales with a black core, and a burning sensation on her cheeks and nose for three months. Initially, small pimples and reddish spots appeared on her face, which grew in size. A dermatological examination of the face showed partly hyperpigmented erythematous plaques, multiple well-defined scales, and partly merged plaques were observed. Discussion: In pediatric cases of DLE, the primary treatment approach involves minimizing exposure to UV radiation using sunscreen. Low-potency topical corticosteroids were administered on active lesions on the facial region. Systemic therapy may be considered, which may involve using immunomodulatory medications such as systemic corticosteroids and antimalarials. However, in this patient’s case, antimalarials were not given as clinical improvement was observed with topical corticosteroids. Conclusion: This case’s DLE diagnosis is based on the patient’s history, physical, and supporting examination. Education on risk factors and drug selection according to complaints is the key to successful therapy for DLE patients.

Hand Eczema in Nurses in COVID-19 Treatment Room: Frequency of Handwashing, Hand Sanitizer, Moisturizer, and Duration of Latex Gloves Use Rosmarwati, Ervina; Widhiati, Suci; Novriana, Dita Eka; Rahma, Alfina; Kariosentono, Harijono; Irawanto, Muhammad Eko; Kusumawardani, Arie; Ellistasari, Endra Yustin; Oktavriana, Triasari
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 2 (2022): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.2.2022.92-98

Background: The COVID-19 pandemic causes health workers to use level 2 and level 3 personal protective equipment. Hand washing and the use of latex gloves are important in limiting the spread of COVID-19, but they can potentially induce hand eczema and skin pH disturbance if used too frequently. Purpose: Determine the correlation between the frequency of handwashing and duration of using hand sanitizer and moisturizer as well as skin pH level on the incidence of hand eczema in nurses in the COVID-19 treatment room at RSUD Dr. Moewardi Surakarta. Methods: This cross-sectional study was conducted in the COVID-19 treatment room at RSUD Dr. Moewardi Surakarta with 90 nurses as subjects. A validated questionnaire carried out the frequency of handwashing, hand sanitizer, moisturizer, duration of using latex gloves, and hand eczema complaints. The subject's pH assessment was conducted after 4-5 hours in the COVID-19 treatment room. Data were analyzed bivariately with a Spearman rank correlation test. Result: There was a significant correlation with the incidence of hand eczema with the frequency of handwashing with soap (r=0.305 and p=0.003) and the duration of using latex gloves (r=0.328 and p=0.002) with a weak category correlation (r=0.200-0.399). The frequency of using hand sanitizer, moisturizer, and skin pH did not correlate with the incidence of hand eczema. Conclusion: Frequency of handwashing and the duration of using latex gloves correlated with the incidence of hand eczema, meanwhile frequency of using hand sanitizer, using moisturizer, and skin pH didn't correlate with the incidence of hand eczema.

The Relationship between Hygiene Behaviour and Acne Vulgaris Incidence in Medical Students Sebelas Maret University Hapsari, Jasmine Rahmi; Murasmita, Alamanda; Widhiati, Suci; Kusumawardani, Arie
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 2 (2022): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.2.2022.125-129

Background: Hygiene behaviour is a person's actions in maintaining cleanliness to prevent the spread of infectious disease by cutting off the transmission of microorganisms that cause infection both in the community and in the health service. Various diseases caused by poor hygiene behaviour are diarrhea, dengue fever, leptospirosis, acute respiratory tract infections, typhoid fever, and various skin infections. One of the infectious skin diseases that affects almost the entire population is acne vulgaris. It is the highest disease prevalence worldwide and ranked 8th with 645.499.139 sufferers. Purpose: To determine the relationship between hygiene behaviour and acne vulgaris incidence in medical students at Sebelas Maret University. Methods: This study was an observational analytical study with a cross-sectional approach. This study was conducted on 45 male medical students at Sebelas Maret University. The questionnaire used was Hygiene Inventory (HI23). Data were analyzed using Fisher's Exact correlation test. Result: There is no relationship (p = 0.720) between hygiene behaviour and acne vulgaris incidence in medical students of the Sebelas Maret University. Conclusion: Hygiene behaviour has no relationship with acne vulgaris incidence in medical students at Sebelas Maret University.

Laporan Kasus Acrodermatitis Enteropathica pada Anak 5 Tahun dengan Level Zink Serum Normal Nareswari, Adniana; Mochtar, Moerbono; Widhiati, Suci; Kusumawardani, Arie; Ellistasari, Endra Yustin; Julianto, Indah
MEDICINUS Vol. 34 No. 1 (2021): MEDICINUS
Publisher : PT Dexa Medica

Acrodermatitis enterophatica (AE) is an inherited or acquired condition associated with zinc malabsorption. Clinical symptoms of AE are periorificial and acral dermatitis, alopecia, and diarrhea. Serum zinc levels usually decrease in AE patients. A 5-year-old boy presented with crusted erosion on the face, trunks and extremities that have been appeared for one year and worsened last month. It also accompanied by hair and eyebrow loss, diarrhea, and eating disorder. Patient was also malnourished. Dermatovenereology examination showed papules, patches, multiple erythematous plaques with squama, erosions with brownish yellow crust above located on perioral, periorbital, posterior trunk, inguinal, perianal, cubital, popliteal and dorsum pedis region. The oral region showed stomatitis and cheilitis. The orbital region showed conjunctival injection and eye discharge. The scalp, eyebrows and lashes showed total alopecia. Laboratory test showed normal serum zinc levels and decreased levels of alkaline phosphatase. The patient was diagnosed with acquired form of AE. Clinical improvement was seen after zinc supplementation. The diagnosis of AE cannot be made only by low serum zinc levels. If a classical triad of AE was found, we must be able to recognize it immediately, thus prompt and appropriate therapy could be given.

The Relationship of Over the Counter (OTC) Facial Soap Usage and Acne Risk in Sebelas Maret University Medical Students Jalasena Mysea, Marsyanda; Kusumawardani, Arie; Murasmita, Alamanda; Widhiati, Suci
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 36 No. 3 (2024): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V36.3.2024.191-195

Background: Acne vulgaris (AV) is a common inflammatory skin disorder among young adults. The use of over-the-counter (OTC) facial soap is a common practice for managing AV, but the impact of its frequency on acne severity remains unclear. Purpose: This study aims to determine the relationship between the frequency of OTC facial soap usage and the severity of acne vulgaris among medical students at Sebelas Maret University. Methods: This observational analytical study utilized a cross-sectional approach and involved 57 medical students at Sebelas Maret University. The questionnaire focused on the frequency of OTC face wash usage among participants. Data were analyzed using Chi-square tests and Spearman-Pearson correlation methods. Result: There is a significant relationship (p = 0.089) between the frequency of OTC face wash usage and the risk of acne vulgaris, with a weak negative correlation (r = -0.226, p = 0.092). This study set a significance level of 0.1, higher than the conventional 0.05, which limits the generalizability of the results. This decision was made to balance the accuracy of the findings with the available resource constraints. Conclusion: There’s a significant correlation between OTC facial soap usage and acne risk in Sebelas Maret University medical students, with more frequent use linked to reduced acne severity.

Co-Authors Anggraeni, Reti Ayu Kusuma Dewi Dharmawan, Nugrohoaji Dita Eka Novriana Dwi Hidayah Ellistasari, Endra Yustin Endraputra, Pristiawan Febriani, Dina Hapsari, Jasmine Rahmi Hartati, Agung Triana Hidayatullah, Lalu Muh Syahrul Rio Indah Julianto, Indah Irawanto, Muhammad Eko Jalasena Mysea, Marsyanda Kamilah, Lian Kariosentono, Harijono Mochtar, Moerbono Mulianto, Nurachmat Murasmita, Alamanda Mustifah, Etty Farida Nareswari, Adniana Nurrachmat Mulianto Prasetyadi Mawardi Prasetyorini, Budi Eko Prihadi, Ihsany Arafiasetyanto Putri, Osdatilla Esa Rafika Paramitasari, Anggana Rahma, Alfina Rosita, Fiska Rosmarwati, Ervina Triasari Oktavriana Widhiati, Suci Widyastuti, Zilpa Yudhistira, Muhammad Yurizar Yustin Ellista Sari, Endra

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