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All Journal Jurnal Pengabdian Masyarakat: Humanity and Medicine Cermin Dunia Kedokteran
Setiawan, Ivon
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Peranan Vitamin E dalam Mencegah Efek Samping Mukokutaneus Isotretinoin Gunawan, Harry; Gabriela, Stefanni; Lukita, Stephanie; Setiawan, Ivon; Dewi, Kardiana Purnama
Cermin Dunia Kedokteran Vol 47, No 10 (2020): Optalmologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (147.879 KB) | DOI: 10.55175/cdk.v47i10.1090

Abstract

Isotretinoin merupakan pilihan terapi oral yang paling efektif untuk kasus akne vulgaris derajat berat, tidak responsif terhadap terapi konvensional, akne dengan jaringan parut berat, dan akne kronis. Efek samping mukokutaneus paling sering dan tergantung dosis (dose-dependent), diduga berkaitan dengan berkurangnya produksi sebum, berkurangnya ketebalan stratum korneum, dan berubahnya fungsi barier epidermis. ATRA (all-transretinoic acid) dapat meningkatkan ekspresi TRAIL, yang merupakan protein ligan TNF-related menginduksi apoptosis. Vitamin E (-tokoferol) dapat menekan jumlah reseptor ligan apoptosis serta mengatur profil lipid epidermal. Beberapa penelitian menunjukkan vitamin E dapat mengurangi efek samping isotretinoin.Isotretinoin is the most effective choice of oral therapy for severe acne, acne unresponsive to conventional therapy, severe acne scars, and chronic acne. Mucocutaneous side effects are the most frequently occurring and dose-dependent, thought to be related to reduced sebum production, reduced stratum corneum thickness, and epidermal barrier function. ATRA (all-trans retinoic acid) increases the expression of TRAIL, a TNF-related ligand protein that induces apoptosis. Vitamin E (-tocopherol) can suppress apoptotic ligand receptors and regulate lipid profiles. Several studies show the advantages of vitamin E in reducing side effects of isotretinoin.
Pelatihan pemeriksaan prevention of disability (POD) kusta pada tenaga Kesehatan dan kader di Kabupaten Prabumulih Nopriyati; Rusmawardiana; Argentina, Fifa; Deddy; Antonius, Cayadi Sidarta; Setiawan, Ivon; Veronica
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 4 No 1 (2023): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V4I1.96

Abstract

Leprosy is a chronic granulomatous infection caused by Mycobacterium leprae. Leprosy infects skin, mucosa and peripheral nerves causing loss of skin sensation with or without skin lesions. Clinical feature of leprosy is highly variable, and can resemble a variety of lesions present in other diseases. Differential diagnosis of skin lesions is so broad that it can lead to misdiagnosis. Based on data from the World Health Organization (WHO) in 2018, it was reported that the number of new cases of leprosy in the world was 210,671 cases, with a new case detection rate of 2.77 per 100,000 population. Indonesia is ranked third in the world as a country with the most new cases of leprosy after India and Brazil. Lack of knowledge of health workers and cadres affects the number of leprosy cases found. This community service activity was carried out with the aim of providing counseling regarding early leprosy examination to health workers and cadres in Prabumulih. The activity was coordinated by Dermatology, Venereology, and Aesthetics Department, Faculty of Medicine, Sriwijaya University, in collaboration with AR Bunda Hospital Prabumulih. At the end of the activity the participants had a better understanding of leprosy and the steps for early leprosy examination. This activity is useful for increasing the knowledge of health workers and cadres about leprosy and how to check for leprosy.
Bakti sosial pemeriksaan, pengobatan skabies dan pendampingan pimpinan dan perangkat di pondok pesantren Kabupaten Prabumulih Rusmawardiana; Nopriyati, Nopriyati; Argentina, Fifa; Deddy, Deddy; Antonius, Cayadi Sidarta; Setiawan, Ivon; Veronica, Veronica
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 4 No 2 (2023): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V4I2.97

Abstract

Scabies is a skin disease caused by infestation and sensitization of Sarcoptes scabiei var. hominis. The prevalence of scabies reaches more than 20% in developing countries and mainly affects children. Scabies is more commonly found in a location with dense population, with high direct or indirect contact, such as in Islamic boarding schools. This counseling and community service activity aims to provide information related to scabies to students and to screen scabies risk factors at Darussalam Prabumulih Islamic Boarding School. The results of the questionnaire screening showed that respondents had a high risk of scabies infestation based on an assessment of the 4 main risk factors. The results of anamnesis and physical examination of 49 students showed that 19 students (38.7%) had scabies infestation and 30 students (61.3%) were free from scabies infestation. This counseling is expected to help reduce the number of scabies infestations in densely populated residential locations, especially in Islamic boarding schools.
Co-Authors Antonius, Cayadi Sidarta Deddy Deddy Deddy Dewi, Kardiana Purnama Fifa Argentina Gabriela, Stefanni Lukita, Stephanie Nopriyati Nopriyati, Nopriyati Rusmawardiana Rusmawardiana, Rusmawardiana Salsabila, Unik Hanifah Veronica VERONICA VERONICA