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All Journal Jurnal Resolusi Konflik, CSR dan Pemberdayaan (Jurnal CARE) Current Biomedicine
Ulandari, Rafika
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Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Anticoagulant effects of combined extracts of Curcuma xanthorrhiza Roxb., Mimusops elengi Linn., and Averrhoa carambola in mice Rahminiwati, Min; Ulandari, Rafika; Hidayat, Rahmat
Current Biomedicine Vol. 3 No. 1 (2025): January
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.3.1.16

Abstract

Background Curcuma xanthorrhiza Roxb. rhizome, the Mimusops elengi Linn. leaves, and Averrhoa carambola leaves contain bioactive compounds such as alkaloids and flavonoids. Flavonoids influence calcium ion levels, which play critical roles in cardiovascular functions, including heart function and blood coagulation. However, the effects of these plant extracts on blood clotting remain unclear. Objective This study aimed to evaluate the anticoagulant effects of a combination of these plant extracts in mice. Methods Twenty-five mice were divided into five treatment groups, receiving either distilled water (0.5 mL/25 g BW), aspirin (0.2 mg/20 g BW), Curcuma xanthorrhiza extract (0.1344 mg/20 g BW), or a combination of the three extracts at two doses (0.63 mg/20 g BW and 2.52 mg/20 g BW). Extracts were administered orally, bleeding and coagulation times were measured at 3-, 6-, and 9-hours post-administration. Results The combined extract significantly prolonged bleeding and coagulation times compared to a single Curcuma xanthorrhiza extract. The most pronounced effect was observed at a dose of 2.52 mg/20 g BW, with the peak effect occurring at the 3rd hour. Conclusion The combination of Curcuma xanthorrhiza, Mimusops elengi, and Averrhoa carambola extracts demonstrated significant anticoagulant activity, with the highest potency observed at a dose of 2.52 mg/20 g BW, surpassing the effects of aspirin. The synergistic interaction between these extracts is suggested to enhance their anticoagulant properties.
PENGENALAN DAN PELATIHAN PEMBUATAN ECO ENZYME PADA PETERNAK AYAM DAN IKAN DI KABUPATEN TAPANULI SELATAN, SUMATERA UTARA Hidayat, Rahmat; Asmara, Alla; Safika; Subhan, Beginer; Afiff, Usamah; Rotinsulu, Dordia Anindita; Hardianti, Aprilia; Jannah, Nor; Islami, Nurfara; Ulandari, Rafika
Jurnal Resolusi Konflik, CSR dan Pemberdayaan (CARE) Vol. 9 No. 2 (2024): Peran Perguruan Tinggi dalam Pemberdayaan Masyarakat
Publisher : Center for Alternative Dispute Resolution and Empowerment (CARE) IPB University

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Abstract

Kegiatan pengenalan dan pelatihan pembuatan eco enzyme pada peternak ayam dan ikan di Kabupaten Tapanuli Selatan, Sumatera Utara, bertujuan untuk meningkatkan pemahaman dan kemampuan para peternak dalam memanfaatkan limbah organik. Eco enzyme, yang dihasilkan dari fermentasi limbah organik seperti sisa buah dan sayuran, digunakan sebagai pupuk organik yang ramah lingkungan, desinfektan rumah tangga, maupun solusi sanitasi untuk peternakan. Program ini melibatkan penyuluhan dan pelatihan langsung kepada peternak ayam dan petani ikan, yang terbukti meningkatkan pengetahuan peserta tentang pembuatan dan aplikasi eco enzyme berdasarkan hasil pengetahuan pre test dan post test. Hasil dari kegiatan ini diharapkan dapat mendukung praktik peternakan yang berkelanjutan dan meningkatkan kesejahteraan ekonomi para peternak.
Co-Authors Afiff , Usamah Alla Asmara Beginer Subhan Hardianti, Aprilia Islami, Nurfara Nor Jannah, Nor Rahmat Hidayat Rahminiwati, Min Rotinsulu, Dordia Anindita Safika S, Safika