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All Journal Majalah Obstetri dan Ginekologi Acta Neurologica Indonesia
Fakhri, Aldithya
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Health Professions Medicine & Pharmacology Neuroscience Public Health

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The impact of micronutrient supplementation on the outcome of In Vitro Fertilization: A comprehensive systematic review of current studies Abdullah, Muhammad Raoul Taufiq; Suryoadji, Kemal Akbar; Fakhri, Aldithya; Hestiantoro, Andon
Majalah Obstetri & Ginekologi Vol. 33 No. 1 (2025): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V33I12025.65-73

Abstract

HIGHLIGHTS Potential benefits of vitamin D3 supplementation >20 ng/ml, along with myo-inositol, folic acid, and melatonin, on implantation rates. Subsequent studies revealed no substantial enhancement in pregnancy rates when specific supplements were used. Further research is needed to provide more definitive conclusions.   ABSTRACT Objective: In vitro fertilization is the most common form of assisted reproductive and fertility technology. However, it is important to note the success rates of IVF generally decrease as a person gets older. Identifying modifiable factors affecting human fertility, including diet, is significant for clinical and community wellness. This systematic review investigates the role of micronutrients supplementation in fertility and its potential impact on in vitro fertilization (IVF) outcomes. Materials and Methods: A systematic search in multiple databases using specific keywords related to in vitro fertilization, micronutrient supplementation, and outcome measures. Results: Out of 1462 retrieved studies, 8 were included in the systematic review. These studies covered a range of micronutrients and their effects on different IVF outcomes. Findings indicated potential benefits of vitamin D3 supplementation. Vitamin D3 supplementation was associated with a significant improvement in implantation rates (p < 0.05) in two studies, while no significant effect was observed in clinical pregnancy rates in other micronutrients. The systematic review highlights the diverse effects of various micronutrient supplements on IVF outcomes. While some supplements showed potential benefits, others did not significantly improve pregnancy rates. Further research with larger cohorts is necessary to establish conclusive evidence. Keywords: micronutrient supplements, IVF outcomes, pregnancy rates. Conclusion: In conclusion, this systematic review sheds light on the impact of micronutrients on IVF outcomes. Some studies suggested potential benefits of vitamin D3 supplementation >20 ng/ml, further research is needed to provide more definitive conclusions. Understanding the function of micronutrients in fertility could have significant implications for IVF treatment and female infertility management.
Effect of Multiple Transcranial Direct Current Stimulation Sessions on Cognitive Function in Parkinson’s Disease: A Systematic Review Martalia, Violine; Fakhri, Aldithya; Andini, Dheanita Nissrina; Gabrian, Arden; Gabrielle, Aileen; Lestari, Yohana Eka Trisnawawti; Prawiroharjo, Pukovisa
Acta Neurologica Indonesia Vol. 4 No. 02 (2026): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v4i02.77

Abstract

Background: Cognitive impairment is a common non-motor symptom of Parkinson’s disease (PD) that significantly affects quality of life. Transcranial direct current stimulation (tDCS), a non-invasive neuromodulation technique, has been proposed to enhance cognitive function in PD. This study systematically reviews the effects of multiple tDCS sessions on cognitive outcomes in PD patients. Methods: A systematic search of PubMed, Cochrane, ScienceDirect, and Medline was conducted in accordance with PRISMA guidelines. Randomized controlled trials (RCTs) assessing the impact of tDCS on cognitive function in PD were included. Study quality was evaluated using the RoB 2 tool. Results: Three RCTs using anodal tDCS over the dorsolateral prefrontal cortex (DLPFC) for 20–25 minutes per session were included. Two studies reported improvements in executive function, attention, memory, and language, with some effects maintained at 3-month follow-up. One study found delayed improvements at 1-month follow-up. However, findings were mixed across studies, especially for memory, language, visuospatial abilities, and global cognition. All studies reported that tDCS was safe and well-tolerated, with only mild, transient side effects. Discussion: Anodal tDCS may enhance specific cognitive functions, particularly executive function and attention, in PD. However, inconsistent findings across studies likely reflect differences in stimulation protocols and outcome measures. Conclusion: While tDCS is a safe intervention, its cognitive efficacy in PD remains uncertain. Methodological variability across studies limits generalizability. Further large-scale RCTs using standardized protocols, consistent cognitive measures, and extended follow-up are needed to clarify the role of tDCS in cognitive rehabilitation for PD.
Co-Authors Abdullah, Muhammad Raoul Taufiq Andini, Dheanita Nissrina Andon Hestiantoro Gabrian, Arden Gabrielle, Aileen Lestari, Yohana Eka Trisnawawti Martalia, Violine Pukovisa Prawiroharjo, Pukovisa Suryoadji, Kemal Akbar