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All Journal The Indonesian Journal of Community and Occupational Medicine eJournal Kedokteran Indonesia Neurona Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Pukovisa Prawiroharjo, Pukovisa
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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PENGGANTIAN MEDIKAMENTOSA PADA PENYAKIT ALZHEIMER Prawiroharjo, Pukovisa; Nari Lastri, Diatri
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 40 No 4 (2024): Volume 40, No 4 - September 2024
Publisher : PERDOSNI

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Abstract

Alzheimer's disease is an age-related neurodegenerative disease. This disease is a major cause of dementia, which is characterized by a progressive decline in cognitive function. Beside the high number of cases, the decline in cognitive function in Alzheimer's disease also causes health problem and social problems, which is a burden for the care giver. It is important to understand the therapeutic management of Alzheimer's patients as well as the procedure for the dose titration and switching therapy to achieve maximum therapeutic effectiveness. Indications for replacement therapy are side effects/intolerance, adherence, drug interactions, dosing profile and low efficacy. Keyword: Alzheimer, dementia, management, medication
RANGKAIAN KASUS CEDERA OTAK PENETRASI: PATOMEKANISME, IMPLIKASI KLINIS, DAN PENATALAKSANAAN DENGAN SUMBER DAYA TERBATAS Andini, Putri; Yugo, Mohammad Reynalzi; Yunus, Reyhan Eddy; Prawiroharjo, Pukovisa
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 40 No 4 (2024): Volume 40, No 4 - September 2024
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v40i2.396

Abstract

Penetrating brain injury differs markedly from blunt injury in dural tears and the transmission of kinetic energy to the surrounding structures along the penetrating tract. Unique clinical characteristics of penetrating brain injury (PBI) certainly require a case-by-case approach, however there are some principles that can be applied in almost every case and need to be considered to improve the outcomes. We present three cases of PBI with different mechanisms and outcomes. Two of the cases presented with non-missile PBI, while the third case presented with missile PBI. We also present a review of current literature highlighting various pathomechanisms, clinical implications and key approaches in managing PBI, particularly in resource-limited settings.
Cedera Otak Traumatis Masif pada Penumpang Kecelakaan Bus Prawiroharjo, Pukovisa; Rahmawati, Mia; Mayza, Adre; Martono, Yessenia
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 40 No 1 (2023): Vol 40 No 1 (2023)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v40i1.397

Abstract

Head injuries from vehicle accidents are the most widely recognized trauma and the primary lead cause of death. Head injuries may happen massively regarding the mass transportation accidents such as bus. While the bus accident happened, it may affect differently of the trauma mechanism of its passenger which result in mortality of some and various disabilities post trauma. Our case reports about massive traumatic brain injury and other trauma clinical condition on some passenger of bus accident with biomechanical analysis of the trauma.
Analysis of The Relationship Between Manual Handling and Individual Factors with De Quervain Syndrome In Workers of Heavy Equipment Manufacturing Company PT. K Finna Fitriana; Soemarko, Dewi Sumaryani; Adi, Nuri Purwito; -, Herqutanto; Prawiroharjo, Pukovisa
The Indonesian Journal of Community and Occupational Medicine Vol. 4 No. 2 (2024): ijcom
Publisher : ILUNI MKK FKUI and PRODI MKK FKUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53773/ijcom.v4i2.137.45-51

Abstract

Introduction: According to the European Occupational Disease Statistics in 2016, as much as 38.1% of Occupational Diseases are Musculoskeletal Disorders. Research in 2013 on the electrical assembly industry in Thailand showed that the most common cause of upper extremity MDS is De Quervain syndrome (DQS) with a prevalence of 13.03%. Previous studies showed that occupational factors are very important as risk factors for DQS, in addition to individual factors. Caused by excessive use of the muscles around the fingers to the wrist, sustained repetitive movements, forceful manual exertion and prolonged static position. In manufacturing industry, the production process need to use tools, machines, and still requires workers for manual work activities and work processes that cannot be replaced by machines. Because manual handling is one of the occupational risk factors for DQS, it is necessary to study DQS in manufacturing industry. This study aims to determine the prevalence of DQS, identify, and analyze the relationship between manual handling and individual factors related to DQS.Method: This research method is a cross sectional using secondary data of PT K employees’ Medical Check-Up (MCU) in 2021. The samples used was all employee’s MCU data with total of 1244 samples. Independent variables include manual handling work factors and individual factors, include age, gender, and years of service. The dependent variable is the De Quervain Syndrome. The DQS was diagnosed with Finkelstein test.Results: A total of 1244 respondents were obtained, with the DQS prevalence 9%. In the analysis of the relationship between manual handling work factor and individual factors (age, sex, and years of service) showed that no significant relationship with suspected DQS in PT K workers. Whereas the multivariate analysis showed that there were no factors that most dominantly influenced DQS, with p>0.05. Conclusion: There is no significant relationship between manual handling work factor and individual factors on suspected DQS.
Neuro-Ophthalmology Manifestations in Brain Tumor Patients and Its Related Factors at dr. Cipto Mangunkusumo Hospital Ariafini, Ni Nengah Rida; Aninditha, Tiara; Sinthia, Novita Ayu; Zairinal , Ramdinal Aviesena; Sitorus, Freddy; Imran, Darma; Prawiroharjo, Pukovisa; Sofyan, Henry Riyanto; Diafiri, Dinda
eJournal Kedokteran Indonesia Vol. 13 No. 1 (2025): Vol 13, No. 1 - April 2025
Publisher : Faculty of Medicine Universitas Indonesia

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Abstract

The visual system has complex connections with all brain areas and can be affected by a brain tumor. Neuro-ophthalmological examinations are important because early diagnosis and managing small tumors will improve outcomes. This study aimed to investigate brain tumors' neuro-ophthalmic (NO) manifestation and the affecting factors. A cross-sectional study using total sampling was conducted in patients undergoing pre-operative examinations from January 2014 to December 2019 in dr. Cipto Mangunkusumo National Referral Hospital. Variables studied in this paper are brain tumor characteristics, NO manifestations, and the relationship between them. Analysis was conducted using chi-square or Fisher's exact test and post hoc analysis. All subjects presented with NO manifestations, with fundoscopic abnormalities (72.9%) as the most common manifestation. The relationships between the tumor type with visual field disturbances (p=0.002) and multiple tumor lesions with funduscopic abnormalities (p=0.043) were significant. Lesion location also had a significant relationship with all NO variables (p<0.05). The NO manifestations were found in all subjects, predominantly the fundoscopic abnormalities. The tumor type, number of lesions, and location of lesions had a significant relationship with NO manifestations.
Biomekanika Cedera Otak Traumatik pada Kecelakaan Mobil Tunggal yang Melibatkan Empat Orang Penumpang Prawiroharjo, Pukovisa; Karmila, Hanna; Mayza, Adre; Martono, Yesenia
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 39 No 3 (2022): Vol 39 No 3 (2022)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i3.398

Abstract

Traumatic Brain Injury (TBI) caused by traffic accidents remains the leading cause of death and disability. Based on data from the Global status report on road safety 2018, deaths caused by traffic accidents occur at a ratio of 18 per 100,000 populations. In traffic accidents, doctors are often asked to perform a verbal autopsy. When performing a verbal autopsy, knowledge of the mechanism of the accident is required to make it easier to analyse the pathomechanism and its implications for the patient. We present a case of an accident involving four passengers, which we reviewed related to the biomechanical process and implications for these four patients. The injuries that occur are influenced by various things such as the seating position in the vehicle, the mechanism of the collision, the vehicle's speed at the time of the collision and various other things, so the four have different injuries. Understanding the biomechanics of injuries in traffic accidents will help medical personnel to unravel the mechanism and sort out the possible causes of injuries
Korteks Prefrontal pada Kelompok Remaja Adiksi Pornografi Lebih Kecil dibandingkan Remaja Tanpa Adiksi Pornografi Prawiroharjo, Pukovisa; Edmi Edison, Rizki; Ellydar, Hainah; Pratama, Peter; Evangeline Imelda Suaidy, Sitti; Amani, Nya'Zata; Carissima, Diavitri; Faradisa Hatta, Ghina
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 39 No 4 (2023): Vol 39 No 4 (2023)
Publisher : PERDOSNI

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Abstract

Background and aims: Increasing popularity of Internet has exposed our children pornography addiction. As in other types of addiction, it affects a brain region known as prefrontal cortex (PFC), which is important in executive functions and inhibitory control. However, this region was loosely defined, and there was no consensus for that definition. We aimed to use volumetric MRI in finding the defining region of PFC which would be suitable in distinguishing pornography addicted juveniles. Methods: We enrolled 30 juveniles (12-16 y.o.) consisting of 15 pornography addiction and 15 non-addiction subjects. We proposed several models of PFC definition from mix-and-matched subregions, consisting of orbitofrontal (OFC), inferior frontal gyrus (IFG; pars orbitalis, opercularis, and triangularis), dorsolateral PFC (DLPFC), and anterior cingulate (ACC). Suitable PFC definition was defined as models which volume statistically different between both groups. Brain volumetric was measured using 3D-T1 3T MRI images and analyzed using FreeSurfer® for automatic cortical reconstruction and brain segmentation (recon-all command). Results: We found significant differences between groups in 6 models, which mainly included OFC, ACC, and DLPFC, with models devoid of DLPFC had lowest mean differences. Conclusion: The most suitable definition of PFC for pornography addiction study should consist of OFC, ACC, and especially DLPFC. Inferior frontal gyrus pars orbitalis was not necessary for this purpose, but may increase effect size if it is included.
Perbandingan Keputusan Rujuk Pasien Stroke Baru Dengan Pasien yang Pernah Didiagnosis Sebelumnya Pada Layanan Telemedis Prawiroharjo, Pukovisa; Kurniawan, Mohammad; Alexander, Fooann
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 3 (2025): Vol 41 No 3 (2024): Volume 41, No 3 - Juni 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i3.665

Abstract

ABSTRACT Introduction: Stroke is the third leading cause of death worldwide. Unfortunately, the high incidence of stroke in Indonesia is not matched by prompt and effective treatment, resulting in a high disability rate. These limitations make decision-making in telemedicine services challenging. Objective: This study aims to compare decision-making related to stroke management between newly diagnosed patients and those previously diagnosed. Methods: This study employed a cross-sectional retrospective design. The data consisted of 256 secondary data obtained from telemedicine company conversations during March and April 2020. Patients were categorized into newly diagnosed stroke patients and previously diagnosed stroke patients. Results: Among the 256 subjects, a significant relationship was found between patient status and decisions regarding referral and pharmacological management. Newly diagnosed stroke patients more frequently received referral decisions, while previously diagnosed patients more often received pharmacological management. Discussion: This study indicates a significant association between patient status and decisions on referral and pharmacological management in telemedicine services. Further studies with larger sample sizes and longer time periods are needed for better representation of conditions in Indonesia. Keywords: patient status, pharmacological treatment, referral, stroke, telemedicine.
Cognitive Function in Type 2 Diabetes Mellitus Patients Taking Metformin and Metformin-Sulfonylurea Rachman, Abu; Sauriasari, Rani; Syafhan, Nadia Farhanah; Prawiroharjo, Pukovisa; Risni, Hindun Wilda
Kesmas Vol. 17, No. 4
Publisher : UI Scholars Hub

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Abstract

The most prescribed antidiabetic drugs in Indonesian primary health care are metformin or a combination of metformin and sulfonylurea. Studies on metformin have shown various impacts on cognitive decline in patients with type 2 diabetes mellitus, whereas sulfonylurea has been shown to reduce this impact. This study aimed to compare the impacts of metformin and metformin-sulfonylurea on cognitive function and determine what factors affected it. This cross-sectional study was conducted at Pasar Minggu Primary Health Care involving 142 type 2 diabetes mellitus patients taking metformin or metformin-sulfonylurea for > 6 months and aged > 36 years. Cognitive function was assessed using the validated Montreal Cognitive Assessment Indonesian version. The effects of metformin and metformin-sulfonylurea on cognitive decline showed no significant difference, even after controlling for covariates (aOR = 1.096; 95% CI = 0.523–2.297; p-value = 0.808). Multivariate analysis showed age (OR = 4.131; 95% CI = 1.271–13.428; p-value = 0.018) and education (OR = 2.746; 95% CI = 1.196–6.305; p-value = 0.017) affected cognitive function. Since a lower education and older age are likely to cause cognitive decline, health professionals are encouraged to work with public health experts to address these risk factors for cognitive function.
Co-Authors -, Herqutanto Adre Mayza Alexander, Fooann Amani, Nya'Zata Aninditha, Tiara Ariafini, Ni Nengah Rida Carissima, Diavitri Dewi Sumaryani Soemarko Diafiri, Dinda Edmi Edison, Rizki Ellydar, Hainah Evangeline Imelda Suaidy, Sitti Faradisa Hatta, Ghina Finna Fitriana Imran, Darma Karmila, Hanna Kurniawan, Mohammad Lastri, Diatri Nari Martono, Yesenia Martono, Yessenia Nadia Farhanah Syafhan Nuri Purwito Adi Pratama, Peter Putri Andini, Putri Rachman, Abu Rahmawati, Mia Rani Sauriasari, Rani Risni, Hindun Wilda Sinthia, Novita Ayu Sitorus, Freddy Sofyan, Henry Riyanto Yugo, Mohammad Reynalzi Yunus, Reyhan Eddy Zairinal , Ramdinal Aviesena