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All Journal Global Medical and Health Communication Jurnal Biomedika dan Kesehatan Jurnal Info Kesehatan
Hermawati, Berty Denny
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Correlation of Interleukin-6 Level with Neutrophil to Lymphocyte Ratio and Disease Severity in COVID-19 Patients Apriningsih, Hendrastutik; Prabowo, Nurhasan Agung; Reviono, Reviono; Anindita, Brigitta Devi; Myrtha, Risalina; Putri, Desy Puspa; Hermawati, Berty Denny
Global Medical & Health Communication (GMHC) Vol 11, No 1 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i1.9643

Abstract

Coronavirus disease 2019 (COVID-19) causes severe acute respiratory disease in humans and has spread rapidly worldwide since its first identification in December 2019. The neutrophil-to-lymphocyte ratio (NLR) describes the balance between the severity of inflammation and the immune system to be used as an important systemic inflammatory marker. Rapid progression of clinical deterioration is characterized by severe respiratory symptoms related to high levels of pro-inflammatory cytokines, like interleukin-6 (IL-6), indicating that the occurrence of cytokine storms leads to increased mortality. This study aims to assess the correlation between IL-6 and NLR in predicting the severity of COVID-19. This prospective cohort study was conducted at the COVID-19 ward of Universitas Sebelas Maret Hospital in August–September 2021. This study involved 66 COVID-19 patients >18 years old with asymptomatic to critical degree and Charlson Comorbidity Index (CCI) value ≤3. Examination of laboratory parameters and serum IL-6 was carried out when the patient entered the Emergency Room. Statistical test with Pearson’s correlation test, significant if p<0.05. There is no significant correlation between IL-6 and NLR with p=0.56 and r=0.08, and a strong correlation between IL-6 and disease severity with p=0.000 and r=0.454. The conclusion is that IL-6 does not correlate with NLR and strongly correlates with disease severity in COVID-19 patients.
ST-Depresi pada Infark Miokard Akut dengan Elevasi Segmen ST–Pentingnya Perubahan Resiprokal pada Elevasi Segmen ST yang Minimal Myrtha, Risalina; Wijayanto, Matthew Aldo; Putri, Desy Puspa; Hermawati, Berty Denny
Jurnal Biomedika dan Kesehatan Vol 7 No 3 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.339-344

Abstract

Coronary artery disease remains the leading cause of mortality globally. Management of ST-elevation myocardial infarction (STEMI) starts from the point of first medical contact. Time delay to treatment influences the mortality in STEMI patients. The aim of this study is to underline the importance of reciprocal ECG changes in helping diagnosis STEMI with subtle ST elevation. We present an obese and hypertensive male patient with atypical symptoms of MI and was diagnosed as peptic ulcer. The ECG showed subtle ST elevation in inferior ECG leads and reciprocal changes in I and aVL. Highly sensitive troponin was elevated. Serial ECG showed evolution, thus revealed acute inferior MI. Successful percutaneous coronary intervention was performed. ECG is one of the most important diagnosis tools in STEMI and a cornerstone to direct the decision to immediate reperfusion therapy. Minimal ST-elevation often leads to inappropriate diagnosis, thus delayed the time to reperfusion. A study shows that 11-23% of STEMI do not reach the cutoff for accepted ECG criteria. In a study of infarctions with minimal ST-elevation, reciprocal changes are reported in 58% of all cases. Reciprocal ECG changes is extremely useful to help identifying STEMI in the absence of obvious ST-elevation on ECG
Association Between Glycated Hemoglobin (HbA1c) Levels and Mean Platelet Volume (MPV) in Patients with Type 2 Diabetes Mellitus Utami, Aloysia Flower Lula; Prabowo, Nurhasan Agung; Hermawati, Berty Denny; Putri, Desy Puspa; Argaheni, Niken Bayu
JURNAL INFO KESEHATAN Vol 24 No 1 (2026): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol24.Iss1.2334

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia, which can trigger inflammatory responses contributing to various vascular complications. Inflammation plays a key role in the pathogenesis of DM-related complications through mechanisms involving oxidative stress and activation of NF-κB signaling, which influence platelet production and activity. Given inconsistent findings regarding the association between HbA1c and mean platelet volume (MPV) in previous studies, this study aims to investigate the relationship between HbA1c and MPV, a pro-thrombotic and inflammatory marker, in patients with type 2 diabetes mellitus. This study is an analytical observational study with a cross-sectional approach. Data were collected from the medical records of Universitas Sebelas Maret (UNS) Hospital, Indonesia, using purposive sampling. HbA1c and MPV data were obtained from patients’ medical records over the past year. Statistical analysis was performed using the Shapiro–Wilk normality test and Pearson correlation test. A total of 38 samples were included in the study. The mean HbA1c level was 10.37% (range: 6.50–16.10), while the mean MPV was 9.38 fL (range: 7.30–12.50). Pearson correlation test showed a significant relationship between HbA1c and MPV (r = 0.467; p = 0.003). There is a significant positive correlation between HbA1c and MPV in patients with type 2 diabetes mellitus.      
Co-Authors Anindita, Brigitta Devi Apriningsih, Hendrastutik Argaheni, Niken Bayu Myrtha, Risalina Prabowo, Nurhasan Agung Putri, Desy Puspa Reviono Reviono Utami, Aloysia Flower Lula Wijayanto, Matthew Aldo