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All Journal IJRETINA - International Journal of Retina Ophthalmologica Indonesiana Cermin Dunia Kedokteran
Sofia, Ovi
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Health Professions Medicine & Pharmacology Public Health

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THE MULTIPLE OCULAR MANIFESTATIONS OF A NEGLECTED NEWLY DIAGNOSED MULTIBACILLARY LEPROSY WITH GRADE II DISABILITY Purnamasari, Suci; Sofia, Ovi
Majalah Oftalmologi Indonesia Vol 51 No 1 (2025): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v51i1.101770

Abstract

Introduction: Leprosy is a chronic granulomatous infection cause by Mycobacterium leprae that could involving the eye with prevalence within 51,6% to 85%. Despite the high prevalence of leprosy and ocular manifestation, ophthalmologist consultation is not routinely performed, thus leads to unrecognized ocular complications. This case report aims to portrays the ocular manifestation of multibacillary leprosy with grade II disability. Case report: A 71-year-old woman presented with severe corneal ulcer with perforation leading to the iris-lens prolapse resulted in total blindness of the left eye; peripheral ulcerative keratitis and neurotropic ulcer of the right eye; lagophthalmos, corneal hypoesthesia, and madarosis of both eye. The Dermatovenereology Department consultation revealed claw hand, ulnar nerve thickening on both upper extremity, and hypoesthesia on both upper and lower limb. The acid fast bacteria were identified from auricula skin scraping specimens with +3 bacterial index (BI) and 75% morphological index (MI). The patient was diagnosed with LE severe corneal ulcer with iris-lens prolapse, RE peripheral ulcerative keratitis (PUK) and neurotropic ulcer, RLE lagophthalmos, and multibacillary leprosy with grade II disability newly diagnosed. Left eye evisceration was performed after initiated the multidrug therapy (MDT) regiment. Conclusion: The ocular manifestation found in this case are corneal hypoesthesia, madarosis, corneal ulcer with perforation, iris-lens prolapse, peripheral ulcerative keratitis, and neurotropic ulcer. The management is directed to pathogen eradication and specific management on ocular manifestation. The collaboration with Dermatovenereology Department is required for comprehensive screening and management.
Peran Tumor Necrosis Factor-Alpha Sistemik pada Respons Imun Toksoplasmosis Okuler Wahyudi, I Nyoman Surya Ari; Sofia, Ovi
Cermin Dunia Kedokteran Vol 52 No 8 (2025): Penyakit Dalam
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i8.1538

Abstract

Ocular toxoplasmosis (OT) is the most common infection causing posterior uveitis worldwide, caused by the parasite Toxoplasma gondii. Many cytokines such as TNF α, IL-6, and IL-10 are involved in the development of uveitis. Tumor necrosis factor (TNF) is a pro-inflammatory cytokine released primarily during inflammatory response of macrophages and T cells, to mediate the activation and infiltration of leukocytes and T helper (Th)1 lymphocyte responses in the tissue. Macular inflammation caused by TO can lead to substantial visual impairment. High level of TNF-α cause disruption of the blood-retinal barrier in uveitis. TNF-α plays a role as a positive regulator of the immune response. Systemic TNF-α levels in ocular infections, particularly TO, increase, which is associated with an increased inflammatory response, contributing to choroidal and retinal tissue damage in TO patients. The TNF-α levels in tissues and intraocular fluid can vary depending on the type and severity of infection. Detection of systemic TNF-α may act a potential clinical biomarker for ocular toxoplasmosis.
The Demographic Profile, Etiology and Outcomes of Acute Postoperative Endophthalmitis Dewi, Amalia Zahra; Sofia, Ovi
International Journal of Retina Vol 8 No 2 (2025): International Journal of Retina (IJRetina) - INAVRS
Publisher : Indonesian Vitreoretinal Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35479/ijretina.2025.vol008.iss002.330

Abstract

Introduction: To describe patient characteristics, bacterial patterns, management, and outcomes of therapy in patients with acute postoperative endophthalmitis. Method: This observational, descriptive study was conducted at Dr. Saiful Anwar General Hospital in Malang, Indonesia, between 2020 and 2024, involving all patients with newly diagnosed acute postoperative endophthalmitis with periode follow up patient's initial visit, on day 7, and on day 28 following treatment Results: A total of 74 patients were included in the study. The majority were male (51.3%), with a mean age of 61.57 ± 11.54 years. The most common comorbid was diabetes mellitus (16.2%). The etiology was most commonly due to gram-negative bacilli (13%), and phacoemulsification was the most common surgical procedure associated with endophthalmitis (74%). Quinolones exhibited the highest sensitivity. The most common management was a combination of medical and surgical treatments, including intravitreal antibiotic injections (59%) and combination of intravitreal antibiotic injections and pars plana vitrectomy (PPV) (18%) . The visual acuity outcomes revealed that 45,9% patients experienced improvement. Conclusion: The incidence of endophthalmitis increases with advancing patient age, correlating with a higher frequency of cataract surgeries performed. Current management outcomes for endophthalmitis are favorable, reflecting improvements aligned with updated clinical guidelines. The comprehensive management of endophthalmitis will result in an improved visual outcome.
DIAGNOSTIC AND THERAPEUTIC CHALLENGES OF POSTERIOR SCLERITIS MIMICKING CHOROIDAL MELANOMA yuniasih, kristina; Dewi, Nadia Artha; Sofia, Ovi
International Journal of Retina Vol 7 No 1 (2024): International Journal of Retina (IJRetina) - INAVRS
Publisher : Indonesian Vitreoretinal Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35479/ijretina.2024.vol007.iss001.256

Abstract

Co-Authors Dewi, Amalia Zahra Nadia Artha Dewi Purnamasari, Suci Wahyudi, I Nyoman Surya Ari Yuniasih, Kristina