Wahyudi, I Nyoman Surya Ari
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Peran Tumor Necrosis Factor-Alpha Sistemik pada Respons Imun Toksoplasmosis Okuler Wahyudi, I Nyoman Surya Ari; Sofia, Ovi
Cermin Dunia Kedokteran Vol 52 No 8 (2025): Penyakit Dalam
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i8.1538

Abstract

Ocular toxoplasmosis (OT) is the most common infection causing posterior uveitis worldwide, caused by the parasite Toxoplasma gondii. Many cytokines such as TNF α, IL-6, and IL-10 are involved in the development of uveitis. Tumor necrosis factor (TNF) is a pro-inflammatory cytokine released primarily during inflammatory response of macrophages and T cells, to mediate the activation and infiltration of leukocytes and T helper (Th)1 lymphocyte responses in the tissue. Macular inflammation caused by TO can lead to substantial visual impairment. High level of TNF-α cause disruption of the blood-retinal barrier in uveitis. TNF-α plays a role as a positive regulator of the immune response. Systemic TNF-α levels in ocular infections, particularly TO, increase, which is associated with an increased inflammatory response, contributing to choroidal and retinal tissue damage in TO patients. The TNF-α levels in tissues and intraocular fluid can vary depending on the type and severity of infection. Detection of systemic TNF-α may act a potential clinical biomarker for ocular toxoplasmosis.
A SUCCESSFULL PNEUMATIC RETINOPEXY FOR THE TREATMENT OF RHEGMATOGENOUS RETINAL DETACHMENT FOLLOWING BLUNT TRAUMA Wahyudi, I Nyoman Surya Ari; Metita, Mirza
International Journal of Retina Vol 7 No 1 (2024): International Journal of Retina (IJRetina) - INAVRS
Publisher : Indonesian Vitreoretinal Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35479/ijretina.2024.vol007.iss001.268

Abstract

Introduction: To report the successful single operative method using Pneumatic Retinopexy as management of rhegmatogenous retinal detachment following ocular blunt trauma. Case Report: A 17 years old boy admitted to clinic with blurred vision in lower part of right eye that worsen over time for 3 weeks with a history of blunt trauma. Initial examination showed the visual acuity of 6/6 on both eyes. Posterior segment evaluation revealed superior retinal detachment on right eye with macular sparing. The main retinal break located in superotemporal part. Patient then treated with Pneumatic Retinopexy using SF6 gas followed by a serial of laser demarcation on right eye. Three months follow up after procedure resulted in reattachment of retina with preserved visual acuity of 6/6 and reduced visual field defect on right eye. Discussion: Rhegmatogenous retinal detachment is the most common form of retinal detachment. Specific procedure of Pneumatic Retinopexy may vary based on expert preference respective surgery. However procedures should always include retinopexy, tamponade by gas and posturing of the patient. Conclusion: Pneumatic Retinopexy is a minimally invasive procedure that can be performed for the management of rhegmatogenous retinal detachment. In order to optimizing post operative outcome, ophthalmologists must be able to select suitable patient, proper examinations and good surgical techniques to achieve a high success rate.
Pengaruh Status Refraksi terhadap Stereopsis Dekat pada Anak Usia Sekolah: Hasil Penelitian Wahyudi, I Nyoman Surya Ari; Wulandari, Lely Retno; Anandita, Nanda Wahyu; Sulistiyowati, Anny
Cermin Dunia Kedokteran Vol 52 No 3 (2025): Oftalmologi dan Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i3.1322

Abstract

Introduction: This study aims to evaluate the effect of refractive status on near stereopsis function among school-age children. Methods: A population-based cross-sectional study in 13 orphanages in Malang city with 334 respondents. Visual acuity (VA) and inter-eye line difference were measured using LogMAR of LVRC chart. Refractive status was determined using spherical equivalent (SE) of autorefractometer, classified into emmetropia, myopia and hypermetropia (low, moderate, and high). Near stereopsis was measured using TNO and Butterfly test in arcsecond and completion time also calculated. Data were analyzed using Kruskal-Wallis and Spearman test. Results: There were significant differences of refractive status and inter-eye line difference to both TNO and butterfly score and time (p<0.05). The group with more severe refractive status and more inter-eye line difference in VA have lower stereopsis score and longer completion time. There were no differences between the age group to both TNO and butterfly score and time (p>0.05). There was a positive correlation between TNO and butterfly test (p<0.05, r= 0.365). Conclusion: There is a significant difference of refractive status and inter-eye line difference on near stereopsis function in school-aged children. Stereopsis test may be beneficial for screening of refractive disorder.