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All Journal Indonesian Journal of Cancer Chemoprevention Universitas Muhammadiyah Yogyakarta Undergraduate Conference Proceeding Pharmacy Reports Pharmaceutical Sciences and Research (PSR)
Arifin, Nuha Haifa
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Upaya Preventif Oleh Tenaga Kesehatan Terhadap Penyebaran ReEmerging Tuberculosis Arifin, Nuha Haifa; Ningrum, Dhecella Winy Cintya
Proceeding Universitas Muhammadiyah Yogyakarta Graduate Conference Vol. 1 No. 1 (2020): Armoring the Youth to Contribute to the SDGs
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (235.449 KB)

Abstract

Tuberculosis merupakan penyakit menular yang disebabkan oleh bakteri Mycobacetrium Tuberculosis yang penyebarannya dapat melalui droplet dan menyebabkan orang disekitarnya menjadi riskan tertular. Seiring berjalannya waktu bakteri pada penyakit ini bermutasi menjadi Multiple Drug Resistence tb (MDR-TB) yang menyebabkannya tidak sensitif lagi terhadap obat-obat TBC yang ada, hal inilah yang menimbulkan Re-Emerging Tuberculosis. Re-Emerging Tuberculosis telah menyebar di sejumlah wilayah Asia dan Afrika, dan kemungkinan akan menjadi sebuah pandemi di dunia, oleh sebab itu perlu adanya upaya preventif oleh tenaga kesehatan sebagai garda terdepan. Penelitian ini dilakukan dengan tujuan untuk mendapatkan solusi terkait upaya pencegahan terhadap penyebaran Re-Emerging Tuberculosis. Metode penelitian yang digunakan adalah pendekatan kualitatif melalui kajian literatur terhadap objek yang dikaji. Hasil penelitian yang kami dapatkan menunjukan bahwa upaya preventif yang dapat dilakukan oleh tenaga kesehatan terhadap penyebaran Re-Emerging Tuberculosis dapat dilakukan melalui 6 kecakapan yang meliputi, pertama, cakap memberikan obat TBC laten sejak dini bagi anak dibawah umur 5 tahun dan ODHA (Orang Dalam HIV/AIDS). Kedua, cakap melakukan pemantauan rutin dan pengobatan yang tepat terhadap tuberculosis yang rentan obat. Ketiga, cakap melakukan imunisasi vaksin BCG (Bacillus Calmette – Guerin) pada bayi. Keempat, cakap melaksanakan tes tuberkulin secara tepat. Kelima, cakap merawat pasien MDR – TB (Multidrug – Resistant Tuberculosis) untuk mencegah penularan, kematian, serta pengembangan XDR – TB (Extensively Drug Resistant Tuberculosis). Keenam, cakap melakukan kampanye edukasi kesehatan seputar TBC melalui media penyiaran nasional. Penulis menyimpulkan bahwa upaya preventif terhadap ReEmerging Tuberculosis perlu dilakukan oleh seluruh masyarakat, terutama oleh tenaga kesehatan guna mencegah timbulnya kemungkinan terjadinya wabah selanjutnya.
Exploration of date palm (Phoenix dactylifera) bioactivity as anti-SARS-CoV-2: in silico study Arifin, Nuha Haifa; Febriansah, Rifki
Pharmacy Reports Vol. 2 No. 3 (2022): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.50

Abstract

The COVID-19 pandemic has highlighted the need for innovation and the development of antiviral agents. One plant with potential antiviral properties is the date palm (Phoenix dactylifera). However, research on the antiviral activity of dates against SARS-CoV-2 is limited. This study aims to assess the antiviral potential of compounds found in date palm fruit using a molecular docking method. Specifically, we compare these compounds to the antiviral drugs ritonavir and nirmatrelvir in their ability to inhibit SARS-CoV-2 proteins. The molecular docking analysis was conducted using various tools and software, including Autodock Vina, DS Visualizer, Autodock Tools, Python, and Marvin Sketch. The results of the study indicate that compounds such as apigenin, diosmetin, and luteolin have strong potential as antiviral agents. The binding affinity of apigenin in date fruit with various SARS-CoV-2 proteins is as follows: -7.6 kcal/mol for 3CL-Pro, -8.7 kcal/mol for Nsp3, -5.7 kcal/mol for PD-ACE-2, and -7.0 kcal/mol for RBD-S. Diosmetin exhibits similar binding affinities with these proteins: -6.7 kcal/mol, -8.5 kcal/mol, -5.6 kcal/mol, and -7.2 kcal/mol, respectively. Luteolin also shows strong binding affinities: -7.9 kcal/mol, -8.6 kcal/mol, -5.7 kcal/mol, and -7.3 kcal/mol. In comparison, nirmatrelvir achieved docking scores of -7.2 kcal/mol, -7.5 kcal/mol, -5.1 kcal/mol, and -6.3 kcal/mol with the same proteins, while ritonavir scored -7.0 kcal/mol, -8.2 kcal/mol, -5.6 kcal/mol, and -6.7 kcal/mol, respectively. Apigenin, diosmetin, and luteolin demonstrate stronger potential than nirmatrelvir and ritonavir, as evidenced by their lower docking scores when compared to these drugs.
Activity of Ethanol Fraction Melinjo (Gnetum Gnemon L.) Seed on Colonic Cancer (Widr) Cells as Co-Chemotherapy Agent Arifin, Nuha Haifa; Febriansah, Rifki; Octavia, Melany Ayu; Kenyori, Ivana Kinanti
Indonesian Journal of Cancer Chemoprevention Vol 14, No 1 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss1pp49-59

Abstract

Cancer deaths increase every year, including in Indonesia. The low selectivity of chemotherapy agents and the resistance of cancer cells against chemotherapy agents is the main cause of chemotherapy treatment failure. It causes serious side effects in sufferers. Beside that, plants produce secondary metabolites which are being investigated for the anticancer activity that is used as new clinical drugs. Therefore we need research that uses plants as co-chemotherapy agents. Melinjo seeds (Gnetum gnemon L.) contain gnetin C has the potential to apoptosis WiDr colon cancer cells. The purpose of this study was to determine the potential of Ethanol Fraction Melinjo Seed (EFMS) as a co-chemotherapy agent for colon cancer. The sample was maceration using 70% ethanol and fractionated with ethanol. Phytochemical screening with thin layer chromatography (TLC)-Densitometry, antioxidant test used the DPPH, while the cytotoxic activity of WiDr colon cancer cells and their combination with 5-Fluorouracil chemotherapy agent using the 3-(4,-5-dimethylthiazo-2-yl)-2,5-diphenyltetrazolium bromide (MTT) Assay, and also in silico test used molecular docking between gnetin C on EFMS and IKK and COX-2 proteins with the 5-FU. The results showed that EFMS contains gnetin C based on Rf value, has weak antioxidant activity with IC50 1227 μg/mL, weak cytotoxic activity in WiDr colon cancer cells with IC50 681 μg/mL and has combined activity synergistic with 5-Fluorouracil. Molecular docking showed gnetin C strong binding affinity against IKK and COX-2 proteins with scores -12.2 kcal/mol and -9.6 kcal/mol. The result concludes that EFMS has the potential to inhibit the development of cancer cells, especially WiDr colon cancer cells.Keywords: Gnetum gnemon L., Colon Cancer, Cytotoxic, Molecular docking, WiDr.
In-Silico Test of Myricetin, Phyllanthin, Luteolin Compounds Against SARS-CoV-2 Proteins Noviyanti, Vidia; Arifin, Nuha Haifa; Ikfini, Hayu; Febriansah, Rifki
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Coronavirus disease 2019 (COVID-19), which emerged in late 2019 and was first detected in Indonesia in March 2020, has significantly reshaped the country’s public health landscape. Aside from the viral outbreak itself, a decline in immunity among the population due to excessive concern about the pandemic has also become a significant issue. This study aimed to evaluate the potential of myricetin, phyllanthin, and luteolin compounds as inhibitors of the SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) virus by targeting the main protease and spike glycoprotein receptor-binding domain proteins through in silico molecular docking. Remdesivir and favipiravir were used as comparison compounds. The molecular docking process involved several stages including structural preparation, protein preparation, method validation, and docking between the compounds with the target protein. The docking results were assessed based on binding energy values, where lower energy indicates a stronger and more stable interaction between the compound and the protein. The binding energies of myricetin, phyllanthin, luteolin, favipiravir and remdesivir compounds with the main protease protein were -6.2, -5.5, -5.3, -4,4, and -5.5 kcal/mol, respectively. The binding energies of those compounds with spike glycoprotein-RBD were -6.0, -4.2, -4.8, -6.0, and -5.3 kcal/mol, respectively. The results showed that myricetin exhibited stronger binding affinity compared to phyllanthin and luteolin and may serve as a promising inhibitor of main protease and spike glycoprotein receptor-binding domain proteins.
Co-Authors Ikfini, Hayu Kenyori, Ivana Kinanti Ningrum, Dhecella Winy Cintya Noviyanti, Vidia Octavia, Melany Ayu Rifki Febriansah