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Evaluation of physical and chemical stability of semi-solid preparations towards beyond-use date Sukamdi, Dyani Primasari; Dewinda, Zulfa Sekar; Damarwati, Vella Lailli; Maziyyah, Nurul; Ningrum, Dhecella Winy Cintya
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 11 No 2 (2023): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2023.11.2.9260

Abstract

Background: Semi-solid formulations require careful consideration due to potential drug interactions and incompatibilities. The stability of these compounds is crucial for determining the quality of a preparation, often assessed by its designated shelf life. Objective: This research synthesizes previous studies to provide a comprehensive assessment of the quality and stability of semi-solid drugs, focusing on evaluating their physical and chemical stability in relation to the Beyond Use Date (BUD). Methods: A literature review was conducted using the Google Scholar database, yielding eight articles that met the established inclusion and exclusion criteria and were pertinent to the research topic. Results: The evaluations of physical stability indicated that preparations are stable when stored under standard conditions, away from light, and when formulated with suitable bases. The chemical stability assessments revealed a decline in potency or concentration at elevated temperatures. Conclusion: The study concludes that, within the parameters of stability evaluated, semi-solid drug preparations remain viable for use.
Upaya Preventif Oleh Tenaga Kesehatan Terhadap Penyebaran ReEmerging Tuberculosis Arifin, Nuha Haifa; Ningrum, Dhecella Winy Cintya
Proceeding Universitas Muhammadiyah Yogyakarta Graduate Conference Vol. 1 No. 1 (2020): Armoring the Youth to Contribute to the SDGs
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (235.449 KB)

Abstract

Tuberculosis merupakan penyakit menular yang disebabkan oleh bakteri Mycobacetrium Tuberculosis yang penyebarannya dapat melalui droplet dan menyebabkan orang disekitarnya menjadi riskan tertular. Seiring berjalannya waktu bakteri pada penyakit ini bermutasi menjadi Multiple Drug Resistence tb (MDR-TB) yang menyebabkannya tidak sensitif lagi terhadap obat-obat TBC yang ada, hal inilah yang menimbulkan Re-Emerging Tuberculosis. Re-Emerging Tuberculosis telah menyebar di sejumlah wilayah Asia dan Afrika, dan kemungkinan akan menjadi sebuah pandemi di dunia, oleh sebab itu perlu adanya upaya preventif oleh tenaga kesehatan sebagai garda terdepan. Penelitian ini dilakukan dengan tujuan untuk mendapatkan solusi terkait upaya pencegahan terhadap penyebaran Re-Emerging Tuberculosis. Metode penelitian yang digunakan adalah pendekatan kualitatif melalui kajian literatur terhadap objek yang dikaji. Hasil penelitian yang kami dapatkan menunjukan bahwa upaya preventif yang dapat dilakukan oleh tenaga kesehatan terhadap penyebaran Re-Emerging Tuberculosis dapat dilakukan melalui 6 kecakapan yang meliputi, pertama, cakap memberikan obat TBC laten sejak dini bagi anak dibawah umur 5 tahun dan ODHA (Orang Dalam HIV/AIDS). Kedua, cakap melakukan pemantauan rutin dan pengobatan yang tepat terhadap tuberculosis yang rentan obat. Ketiga, cakap melakukan imunisasi vaksin BCG (Bacillus Calmette – Guerin) pada bayi. Keempat, cakap melaksanakan tes tuberkulin secara tepat. Kelima, cakap merawat pasien MDR – TB (Multidrug – Resistant Tuberculosis) untuk mencegah penularan, kematian, serta pengembangan XDR – TB (Extensively Drug Resistant Tuberculosis). Keenam, cakap melakukan kampanye edukasi kesehatan seputar TBC melalui media penyiaran nasional. Penulis menyimpulkan bahwa upaya preventif terhadap ReEmerging Tuberculosis perlu dilakukan oleh seluruh masyarakat, terutama oleh tenaga kesehatan guna mencegah timbulnya kemungkinan terjadinya wabah selanjutnya.
Anticancer Activity of The Ethanol Fraction of Gnetum gnemon L. Seeds on HeLa Cell Lines Rahmawati, Devi; Ningrum, Dhecella Winy Cintya; Kenyori, Ivana Kinanti; Febriansah, Rifki; Octavia, Melany Ayu; Hermawansyah, Adi
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 23, No 2 (2023): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v23i2.18421

Abstract

Cervical cancer results from abnormal cell development in the cervix and is caused by the Human Papillomavirus (HPV). Cancer treatment with chemotherapy drugs has dangerous side effects because it can attack normal cells. Gnetum gnemon L. seeds are known to possess anticancer potential. Therefore, natural ingredients are necessary to develop new cancer drug strategies with minimal side effects. This study aims to determine the anticancer activity of the ethanol fraction of Gnetum gnemon L. Seeds (EFGS) against HeLa cells. The research method used in this study was an identification test to detect compounds from EFGS using the TLC method and the HeLa cell cytotoxic test using the MTT Assay method. The results showed that EFGS contained stilbenoid group compounds based on TLC-Densitometry, with an Rf value of 0.22 cm. The cytotoxic test results on HeLa cells indicated an IC50 value of 784 µg/mL, classifying it as having the potential as a moderate category anticancer agent. Therefore, this study indicates that EFGS can be utilized as a chemopreventive agent.