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All Journal Indonesian Journal of Cancer Chemoprevention Mutiara Medika: Jurnal Kedokteran dan Kesehatan Acta Pharmaciae Indonesia : Acta Pharm Indo Universitas Muhammadiyah Yogyakarta Undergraduate Conference Proceeding
Ningrum, Dhecella Winy Cintya
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Public Health Social Sciences

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Evaluation of physical and chemical stability of semi-solid preparations towards beyond-use date Sukamdi, Dyani Primasari; Dewinda, Zulfa Sekar; Damarwati, Vella Lailli; Maziyyah, Nurul; Ningrum, Dhecella Winy Cintya
Acta Pharmaciae Indonesia Vol 11 No 2 (2023): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2023.11.2.9260

Abstract

Background: Semi-solid formulations require careful consideration due to potential drug interactions and incompatibilities. The stability of these compounds is crucial for determining the quality of a preparation, often assessed by its designated shelf life. Objective: This research synthesizes previous studies to provide a comprehensive assessment of the quality and stability of semi-solid drugs, focusing on evaluating their physical and chemical stability in relation to the Beyond Use Date (BUD). Methods: A literature review was conducted using the Google Scholar database, yielding eight articles that met the established inclusion and exclusion criteria and were pertinent to the research topic. Results: The evaluations of physical stability indicated that preparations are stable when stored under standard conditions, away from light, and when formulated with suitable bases. The chemical stability assessments revealed a decline in potency or concentration at elevated temperatures. Conclusion: The study concludes that, within the parameters of stability evaluated, semi-solid drug preparations remain viable for use.
Upaya Preventif Oleh Tenaga Kesehatan Terhadap Penyebaran ReEmerging Tuberculosis Arifin, Nuha Haifa; Ningrum, Dhecella Winy Cintya
Proceeding Universitas Muhammadiyah Yogyakarta Graduate Conference Vol. 1 No. 1 (2020): Armoring the Youth to Contribute to the SDGs
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (235.449 KB)

Abstract

Tuberculosis merupakan penyakit menular yang disebabkan oleh bakteri Mycobacetrium Tuberculosis yang penyebarannya dapat melalui droplet dan menyebabkan orang disekitarnya menjadi riskan tertular. Seiring berjalannya waktu bakteri pada penyakit ini bermutasi menjadi Multiple Drug Resistence tb (MDR-TB) yang menyebabkannya tidak sensitif lagi terhadap obat-obat TBC yang ada, hal inilah yang menimbulkan Re-Emerging Tuberculosis. Re-Emerging Tuberculosis telah menyebar di sejumlah wilayah Asia dan Afrika, dan kemungkinan akan menjadi sebuah pandemi di dunia, oleh sebab itu perlu adanya upaya preventif oleh tenaga kesehatan sebagai garda terdepan. Penelitian ini dilakukan dengan tujuan untuk mendapatkan solusi terkait upaya pencegahan terhadap penyebaran Re-Emerging Tuberculosis. Metode penelitian yang digunakan adalah pendekatan kualitatif melalui kajian literatur terhadap objek yang dikaji. Hasil penelitian yang kami dapatkan menunjukan bahwa upaya preventif yang dapat dilakukan oleh tenaga kesehatan terhadap penyebaran Re-Emerging Tuberculosis dapat dilakukan melalui 6 kecakapan yang meliputi, pertama, cakap memberikan obat TBC laten sejak dini bagi anak dibawah umur 5 tahun dan ODHA (Orang Dalam HIV/AIDS). Kedua, cakap melakukan pemantauan rutin dan pengobatan yang tepat terhadap tuberculosis yang rentan obat. Ketiga, cakap melakukan imunisasi vaksin BCG (Bacillus Calmette – Guerin) pada bayi. Keempat, cakap melaksanakan tes tuberkulin secara tepat. Kelima, cakap merawat pasien MDR – TB (Multidrug – Resistant Tuberculosis) untuk mencegah penularan, kematian, serta pengembangan XDR – TB (Extensively Drug Resistant Tuberculosis). Keenam, cakap melakukan kampanye edukasi kesehatan seputar TBC melalui media penyiaran nasional. Penulis menyimpulkan bahwa upaya preventif terhadap ReEmerging Tuberculosis perlu dilakukan oleh seluruh masyarakat, terutama oleh tenaga kesehatan guna mencegah timbulnya kemungkinan terjadinya wabah selanjutnya.
Anticancer Activity of The Ethanol Fraction of Gnetum gnemon L. Seeds on HeLa Cell Lines Rahmawati, Devi; Ningrum, Dhecella Winy Cintya; Kenyori, Ivana Kinanti; Febriansah, Rifki; Octavia, Melany Ayu; Hermawansyah, Adi
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 23, No 2 (2023): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v23i2.18421

Abstract

Cervical cancer results from abnormal cell development in the cervix and is caused by the Human Papillomavirus (HPV). Cancer treatment with chemotherapy drugs has dangerous side effects because it can attack normal cells. Gnetum gnemon L. seeds are known to possess anticancer potential. Therefore, natural ingredients are necessary to develop new cancer drug strategies with minimal side effects. This study aims to determine the anticancer activity of the ethanol fraction of Gnetum gnemon L. Seeds (EFGS) against HeLa cells. The research method used in this study was an identification test to detect compounds from EFGS using the TLC method and the HeLa cell cytotoxic test using the MTT Assay method. The results showed that EFGS contained stilbenoid group compounds based on TLC-Densitometry, with an Rf value of 0.22 cm. The cytotoxic test results on HeLa cells indicated an IC50 value of 784 µg/mL, classifying it as having the potential as a moderate category anticancer agent. Therefore, this study indicates that EFGS can be utilized as a chemopreventive agent.
Bioinformatics and Molecular Docking Study of Amentoflavone and 3,8-Biapigenin as Inhibitors on Cervical Cancer Proteins Ningrum, Dhecella Winy Cintya; Kusumaningtyas, Triana Arum; Febriansah, Rifki; Juniananda, Melisa; Tasminatun, Sri; Krisridwany, Annisa
Indonesian Journal of Cancer Chemoprevention Vol 14, No 2 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss2pp105-116

Abstract

Cervical cancer maintains its second-place ranking for Indonesia's highest number of cancer cases. In 2021, there were 36,633 cases of cervical cancer in Indonesia, with a rising death rate. Commonly, chemotherapy is used to treat cervical cancer and can improve the survival chances of patients, but these therapies imply increased toxicity. Biflavonoid group compounds like amentoflavone and 3,8-Biapigenin have the potential to act as anticancer agents by modulating multiple signaling pathways. This study aims to determine the cervical anticancer potential of amentoflavone and 3,8-Biapigenin based on in silico study. Prediction of anticancer activity in silico using Prediction of Activity Spectra for Active Substances (PASS) online, followed by target protein tracing using STITCH-STRING, then receptor analysis test using Ramachandran plot. A molecular docking test was conducted to determine the binding affinity of the compound with the receptor. Based on the online PASS, the compounds as thought to have low cervical anticancer potential if tested on a laboratory scale. STAT3, EP300, CYP1A1, and AKR1C1 proteins used in this study have met the requirements of a suitable receptor for molecular docking test. The best binding affinity was obtained at the interaction of amentoflavone and STAT3 with a better docking score (-9.3 kcal/mol) than doxorubicin (-7.1 kcal/mol). Overall, the results suggest biflavonoid compounds have the potential to be developed as a chemopreventive agent for cervical cancer.Keywords: bioinformatics, molecular docking, amentoflavone, 3,8-Biapigenin, cervical cancer protein.
In Silico and In Vitro Study Selaginella doederleinii Herb Extract as An Antineoplastic on MCF-7 Cells and Formulation Development of Nano Effervescent Granule Anggraini, Chaessy Yori; Kusumaningtyas, Triana Arum; Juniananda, Melisa; Ningrum, Dhecella Winy Cintya; Febriansah, Rifki; Hermawansyah, Adi
Indonesian Journal of Cancer Chemoprevention Vol 14, No 2 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss2pp128-138

Abstract

Breast cancer, the leading cause of cancer-related deaths in women with 685,000 deaths in 2020. Exploring natural compounds with minimal side effects has emerged as a potential treatment. However, utilizing natural substances faces challenges, such as poor bioavailability, requiring technologies like nanotechnology to enhance absorption. This study focuses on evaluating Ethanol Extract of Selaginella doederleinii (EESD) as an anticancer against MCF-7, both in silico, in vitro methode and develop a formulation of EESD nanoparticle effervescent granules. This study commenced with extraction, Gas Chromatography-Mass Spectrometry (GC-MS) identification, in silico studies, namely bioinformatics and molecular docking, 3-(4,-5-dimethylthiazo-2-yl)-2,5-diphenyltetrazolium bromide (MTT) Assay tests on MCF-7, and the formulation of nanoparticle preparations. EESD was extracted using the maceration method, resulting in an extract weighing 103.5 grams with a 6.9% yield. GC-MS identified three major compounds—cyclopentadecanoic, 2-hydroxy; hexadecanoic acid; and 9-octadecanoid, methyl ester. Bioinformatics revealed interactions with specific protein targets, and molecular docking indicated hexadecanoic acid's superior binding to TP53, surpassing paclitaxel at -8.7 kcal/mol. This suggests its potential to modulate TP53, impacting P53's role in impeding cancer cell growth. EESD exhibited an IC50 of 215μg/mL, signifying moderate cytotoxicity. In formulating nanoparticle effervescent granules, five formulas were transformed into nanoparticles and underwent organoleptic, pH, granule dissolution, and water content evaluations. Formula I is the formula that best meets the criteria with a pH of 6.55, granule dissolution <5 minutes, and water content <4%. The research results indicate that EESD shows anticancer activity against MCF-7 and this study has successfully developed a formula of nanoparticle from EESD in effervescent granule form.Keywords: Selaginella doederleinii, breast cancer, co-Cemotheraphy, MCF-7 Cell, in silico.
Co-Authors Adi Hermawansyah Anggraini, Chaessy Yori Arifin, Nuha Haifa Devi Rahmawati, Devi Dewinda, Zulfa Sekar Juniananda, Melisa Kenyori, Ivana Kinanti Krisridwany, Annisa Kusumaningtyas, Triana Arum Nurul Maziyyah Octavia, Melany Ayu Rifki Febriansah Sri Tasminatun Vella Lailli Damarwati