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All Journal Nexus Biomedika Magna Neurologica
Hana Amatillah
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Efek Hepatoprotektif Sari Belimbing Manis Terhadap Kadar SGPT: Studi Awal Terhadap Tikus yang Diinduksi Parasetamol Dosis Toksik Amatillah, Hana; Ediningsih, Endang; Hikmayani, Nur Hafidha
Nexus Biomedika Vol 2, No 3 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13.862 KB)

Abstract

Background: Star fruit is a good source of natural antioxidants which can prevent oxidative damages and modulate reactive free-radicals. However, no study had been carried out so far on the hepatoprotective effect of star fruit. This research aimed to study the hepatoprotective effect of star fruit juice on SGPT level in paracetamol- intoxicated rats. Methods: This was a laboratory experimental study with posttest only controlled group design. A total of 30 white male, Wistar rats (Rattus norvegicus), aged 2-3 months and weighed 160-200 grams was assigned into five groups. Normal group and negative control group were administered distilled water, while positive control group was administered Curcuma® (3.6 mg/200 g bw). The treatment group 1 and 2 were administered star fruit juice at concentration of 50% and 100%, successively. This study was performed for 14 days. In the last 3 days, all groups except normal group were induced by paracetamol at toxic dose (291.6 mg/200 g BW) an hour after the treatment of star fruit juice (for treatment group 1 and 2) was done. Blood samples were collected from retro-orbitalis venous to measure SGPT levels. The data were analyzed statistically using one-way ANOVA followed by LSD test. Results: The analysis of SGPT with one-way ANOVA showed a significant difference across all groups. Further, the LSD tests of SGPT level showed significant differences between negative control group (182.5 U/L ± 14.0) and the two star fruit groups (p values <0.001). SGPT mean in treatment group 1 (87.0 U/L ± 14.1) and treatment group 2 (91.7 U/L ± 14.9) also differed from those of positive control (67.1 U/L ± 5.5, p=0.008) and normal group (53.8 U/L ± 8.6, p=0.002). There was no significant difference between two groups treated with star fruit juice (p=0.511). Conclusions: Star fruit juice at concentration of 50% and 100%  significantly inhibited the elevation of SGPT levels in paracetamol-intoxicated rats. Keywords: Star fruit juice, SGPT, paracetamol, rats 
Efek Hepatoprotektif Sari Belimbing Manis Terhadap Kadar SGPT: Studi Awal Terhadap Tikus yang Diinduksi Parasetamol Dosis Toksik Hana Amatillah; Endang Ediningsih; Nur Hafidha Hikmayani
Nexus Biomedika Vol 2, No 3 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Star fruit is a good source of natural antioxidants which can prevent oxidative damages and modulate reactive free-radicals. However, no study had been carried out so far on the hepatoprotective effect of star fruit. This research aimed to study the hepatoprotective effect of star fruit juice on SGPT level in paracetamol- intoxicated rats. Methods: This was a laboratory experimental study with posttest only controlled group design. A total of 30 white male, Wistar rats (Rattus norvegicus), aged 2-3 months and weighed 160-200 grams was assigned into five groups. Normal group and negative control group were administered distilled water, while positive control group was administered Curcuma (3.6 mg/200 g bw). The treatment group 1 and 2 were administered star fruit juice at concentration of 50% and 100%, successively. This study was performed for 14 days. In the last 3 days, all groups except normal group were induced by paracetamol at toxic dose (291.6 mg/200 g BW) an hour after the treatment of star fruit juice (for treatment group 1 and 2) was done. Blood samples were collected from retro-orbitalis venous to measure SGPT levels. The data were analyzed statistically using one-way ANOVA followed by LSD test. Results: The analysis of SGPT with one-way ANOVA showed a significant difference across all groups. Further, the LSD tests of SGPT level showed significant differences between negative control group (182.5 U/L 14.0) and the two star fruit groups (p values <0.001). SGPT mean in treatment group 1 (87.0 U/L 14.1) and treatment group 2 (91.7 U/L 14.9) also differed from those of positive control (67.1 U/L 5.5, p=0.008) and normal group (53.8 U/L 8.6, p=0.002). There was no significant difference between two groups treated with star fruit juice (p=0.511). Conclusions: Star fruit juice at concentration of 50% and 100% significantly inhibited the elevation of SGPT levels in paracetamol-intoxicated rats. Keywords: Star fruit juice, SGPT, paracetamol, rats
Virtual Reality-Based Rehabilitation’s Impact on Movement and Quality of Life in Parkinson’s: An Updated Systematic Review of Randomized Controlled Trials Muvida; Mustikasari, Hanif; Belawati, Yeny Ristaning; Amatillah, Hana
Magna Neurologica Vol. 3 No. 1 (2025): January
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v3i1.1720

Abstract

Background: Parkinson’s disease is a neurodegenerative disorder that can significantly impact an individual’s mobility, balance, and overall quality of life. It is characterized by movement disorders, including tremors, rigidity, bradykinesia, and gait disorder. In addition to pharmacological therapy, rehabilitation approaches play an important role in the management of occurring movement disorders. One of the potential rehabilitation methods is virtual reality (VR). Objective: This systematic review aims to determine the impact of VR-based rehabilitation on balance, mobility, motor function, and the quality of life of Parkinson's patients. Methods: Systematic research was conducted in February 2024 using PubMed, Scopus, and ScienceDirect. A combination of MeSH terms “virtual reality,” “Parkinson,” “exergame,” “effectivity,” and “rehabilitation” was used. The articles selected were randomized controlled trials published in the last ten years in English. The quality of articles was assessed using the Cochrane risk-of-bias tool. Analyses were stratified by outcomes: balance, mobility, motor function, and quality of life. Results: Fourteen randomized controlled trials with 637 patients were included. Most trials show that VR-based rehabilitation significantly improves balance compared to conventional rehabilitation. Mobility and motor function improve in the VR group, but its superiority remains controversial. Improved quality of life is observed, but no trials show statistical significance compared to conventional rehabilitation. Conclusion: This systematic review shows that VR-based rehabilitation has the potential to improve balance, mobility, motor function, and quality of life in Parkinson's patients.
Co-Authors Endang Ediningsih Hanif Mustikasari Muvida Nur Hafidha Hikmayani Nur Hafidha Hikmayani Yeny Ristaning Belawati