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All Journal Pharmaceutical Sciences and Research (PSR) Makara Journal of Science
Juheini Amin
Fakultas Farmasi Universitas Indonesia

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Journal : Makara Journal of Science

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ACTIVITY OF ETHANOLIC EXTRACT FROM Justicia gendarussa Burm. LEAVES ON DECREASING THE URIC ACID PLASMA Basah, Katrin; Elya, Berna; Amin, Juheini; Julian, Muhamad Iqbal
Makara Journal of Science Vol. 15, No. 1
Publisher : UI Scholars Hub

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The effect of Justicia gendarussa leaves extract has been investigated using oxonate-induced hyperuricemic male albino rats. In this experiment thirty five male albino rats were divided randomly into seven groups. There were three group doses variations of J. gendarussa extract that were 1.3 g/kg bw, 2.6 g/kg bw and 5.2 g/kg bw; two comparison groups that were allopurinol 0.68 g/kg bw and herbal “X” 0.85 g/kg bw; and two control groups that were induced control potassium oxonate 0.25 mg/kg bw and normal control CMC 0,5 %. Intraperitoneal administration of potassium oxonate 0.25 mg/kg bw was given one hour before administration of test drugs in eight day and plasma uric acid was measured in rats after two hours. Plasma uric acid was measured by spectrophotometric on 520 nm with enzymatic method. The results showed that all extracts could reduced uric acid level of rats. The decreasing potency of uric acid level was equal to doses increase, so the best result that can reduce uric acid level was J. gandarussa extract at a dose 5.2 g/ kg bw. This results indicated that J. gendarussa leaves extract may be effective for the prevention and the treatment of hyperuricemia.
TOKSISITAS AKUT DAUN Justicia gendarussa Burm Elya, Berna; Amin, Juheini; Emiyanah, Emiyanah
Makara Journal of Science Vol. 14, No. 2
Publisher : UI Scholars Hub

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Acute Toxicity of Justicia gendarussa Burm. Leaves. Preminelary experiment showed that ethanolic extract of gandarusa leaves (Justicia gendarussa Burm.) could decreased uric acid blood level on rats. The aim of this experiment was to determine of the value LD50 and liver function based on activities of aminotransferase. Animals test which were used in this experiment were 50 males and 50 females white mice. They were divided into 5 groups. Group 1 as control group was given aquadest. Group 2-5 were treated by ethanolic extract of gandarusa leaves with dosage 4, 8, 16, and 32 g/kg bw. The LD50 value was determined by the amount of death in group during 24 hours after giving a single dose of test substance. The result showed that the highest dose was practically non toxic with LD50 value of 31.99 g/kg bw (male groups) and 27.85 g/kg bw (female groups). Measurement of aminotransferase activity was done by using colorimetric method. The result of ANOVA analysis for liver function showed that the giving test substance 4 g/kg bw –16 g/kg bw was not significantly different between treated groups and control group.
Co-Authors . Katrin Anita Ayu Dwi Ajie Saputri, Anita Ayu Dwi Ajie Basah, Katrin Berna Elya Emiyanah, Emiyanah Joshita Djajadisastra, Joshita Julian, Muhamad Iqbal MARIA BINTANG Mia Permawati Retnosari Andrajati Santi Purna Sari Sari, Rusmalita Pebriana Widiarti Widiarti