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Huthia Andriyana

Faculty of Medicine University of Indonesia/ Dr. Cipto Mangunkusumo Hospital Jakarta

Author-ID : 227953

Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Articles

Ovarian Tissue Vitrification as a Method for Ovarian Preservation in Women with Cancer: an Analysis of Granulose Cell Apoptosis Wiweko, Budi; Andriyana, Huthia; Aulia, Achmad
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No. 2, April 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To obtain the effective method of ovarian function preservation with granulose cell apoptosis assessment. Ovarian tissue vitrification became a method for ovarian function preservation in women with cancer. This technique can be done anytime without delay on cancer therapy both in prepubertal and unmarried patient. It can also store many primordial follicles. Ovarian tissue vitrification study is still limited to animal test and there are no data about apoptosis assessment after ovarian vitrification in human ovary. Method: This quasi experimental study was held in Department of Obstetrics and Gynecology Faculty of Medicine University of Indonesia - Dr. Cipto Mangunkusumo General Hospital and Fatmawati Hospital Jakarta from March 2012 to May 2015. Ovaries from thirteen women between 31 and 37 years old who underwent oophorectomy with gynecological indication were examined. Result: There was no morphological difference between follicles from fresh and warmed-vitrified ovaries. The mean protein Bax expression on the fresh ovaries assessed in the form of H-score was 1.66 (SD 0.14) compared with 1.68 (SD 0.13) on the warmedvitrified group (p=0.165). The mean protein Bcl-2 expression on the fresh ovaries examined in the form of H-score was 1.73 (SD 0.10) compared with 1.71 (SD 0.10) on the warmed-vitrified group (p=0.068). Conclusion: Ovarian tissue vitrification does not affect the Bax and Bcl-2 expression on human ovary. [Indones J Obstet Gynecol 2016; 4-2: 88-92] Keywords: apoptosis, bax, Bcl-2, ovarian tissue vitrification

Ovarian Tissue Vitrification as a Method for Ovarian Preservation in Women with Cancer: an Analysis of Granulose Cell Apoptosis Wiweko, Budi; Andriyana, Huthia; Aulia, Achmad
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No. 2, April 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To obtain the effective method of ovarian function preservation with granulose cell apoptosis assessment. Ovarian tissue vitrification became a method for ovarian function preservation in women with cancer. This technique can be done anytime without delay on cancer therapy both in prepubertal and unmarried patient. It can also store many primordial follicles. Ovarian tissue vitrification study is still limited to animal test and there are no data about apoptosis assessment after ovarian vitrification in human ovary. Method: This quasi experimental study was held in Department of Obstetrics and Gynecology Faculty of Medicine University of Indonesia - Dr. Cipto Mangunkusumo General Hospital and Fatmawati Hospital Jakarta from March 2012 to May 2015. Ovaries from thirteen women between 31 and 37 years old who underwent oophorectomy with gynecological indication were examined. Result: There was no morphological difference between follicles from fresh and warmed-vitrified ovaries. The mean protein Bax expression on the fresh ovaries assessed in the form of H-score was 1.66 (SD 0.14) compared with 1.68 (SD 0.13) on the warmedvitrified group (p=0.165). The mean protein Bcl-2 expression on the fresh ovaries examined in the form of H-score was 1.73 (SD 0.10) compared with 1.71 (SD 0.10) on the warmed-vitrified group (p=0.068). Conclusion: Ovarian tissue vitrification does not affect the Bax and Bcl-2 expression on human ovary. [Indones J Obstet Gynecol 2016; 4-2: 88-92] Keywords: apoptosis, bax, Bcl-2, ovarian tissue vitrification

Hubungan Tingkat Stres dengan Siklus Menstruasi pada Mahasiswi Universitas Gunadarma Haikal, Muhammad; Andriyana, Huthia; Sudomo, Danurwendo
Health Information : Jurnal Penelitian Content Digitized
Publisher : Poltekkes Kemenkes Kendari

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Menstruasi merupakan suatu siklus peluruhan dinding endometrium sebagai respon terhadap interaksi hormon yang dihasilkan oleh hipotalamus, hipofisis dan ovarium. Siklus menstruasi di pengaruhi oleh beberapa faktor seperti status gizi, IMT, aktivitas fisik, kondisi hormonal dan stres. Stres merupakan bagian yang normal yang sering kita hadapi. Semua yang menghasilkan stres disebut stressor. Pada mahasiswa ketika menghadapi atau menjalani kuliah yang terlalu padat, praktikum, tugas, dan proses pembuatan skripsi merupakan faktor yang dapat memicu terjadinya stres sehingga menyebabkan siklus menstruasi menjadi tidak teratur. Maksud dari penelitian ini adalah untuk menyelidiki apakah ada korelasi antara tingkat stres dan pola siklus menstruasi pada mahasiswi di Universitas Gunadarma. Penelitian ini menggunakan pendekatan kuantitatif analitis dengan desain potong lintang (cross-sectional) dan menerapkan teknik sampling acak sederhana. Partisipasi dalam penelitian ini melibatkan 195 individu yang memenuhi kriteria inklusi dan eksklusi. Data yang terkumpul dianalisis menggunakan uji Chi-Square. Temuan dari analisis ini mengindikasikan bahwa nilai P dalam penelitian ini sebesar 0,001, menandakan bahwa nilai tersebut berada di bawah ambang signifikansi 0,05. Oleh karena itu, dapat diambil kesimpulan bahwa terdapat hubungan yang bermakna antara tingkat stres dan pola siklus menstruasi pada mahasiswi Universitas Gunadarma.

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