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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Indonesian Journal of Cancer Chemoprevention Business UHO: Jurnal Administrasi Bisnis Makara Journal of Science Millatuna: Jurnal Studi Islam
Rina Andriyani
Research Center for Chemistry, Indonesian Institute of Sciences, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Environmental Science Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Social Sciences Other

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Isolation of an Anti-Cancer Asperuloside from Hedyotis corymbosa L. Artanti, Nina; Hanafi, Muhammad; Andriyani, Rina; Saraswaty, Vienna; Udin, Linar Zalinar; Lotulung, Puspa D; Fujita, Ken Ichi; Usuki, Yoshinosuke
Journal of Tropical Life Science Vol 5, No 2 (2015)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.05.02.06

Abstract

Hedyotis corymbosa, with local name rumput mutiara, is an anti-inflammatory, anti-cancer and hepatoprotective traditional medicine.  The ethanol extract of H. corymbosa L. shows inhibitory activity to human YMB-1 breast cancer cell line with an IC50 of 6.51 mg/ml.  The methylene chloride fraction shows a potential cytotoxic activity with an IC50 of 2.75 mg/ml.  To obtain a lead compound, the extract was further purified by column chromatography. A pure compound is obtained which shows inhibitory activities against YMB-1, HL60 and KB human cell lines with IC50 values of 0.7; 11.0 and 104.2 mg/ml, respectively.  Based on the 1D and 2D FT-NMR data, the isolated compound is an asperuloside.
Co-Authors A.A. Ketut Agung Cahyawan W Amanda, Tiffany Azhra Athanasia Amanda Septevani, Athanasia Amanda Chandra Risdian Dewi Nilawati, Dewi Ken Ichi Fujita, Ken Ichi Laily Masruroh Linar Zalinar Udin, Linar Zalinar Mawarda, Panji Cahya Mia Miranti Rustama Nina Artanti Puspa D Lotulung, Puspa D Puti Sri Komala Putra, Alqadri Asri Sembiring, Tarzan Vienna Saraswaty, Vienna Widyarani, Widyarani Yoshinosuke Usuki, Yoshinosuke Zalinar Udin