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All Journal Indonesian Journal of Cancer Chemoprevention Journal of Islamic Medicine
Qonita, Kesimira
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Systematic Review : Kajian Fitokimia Dan Potensi Farmakologi Jeruk Pamelo (Citrus Maxima) Mutiah, M.Kes, Roihatul; Qonita, Kesimira; Luthfi, Fitrati Hasanah
Journal of Islamic Medicine Vol 7, No 2 (2023): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2023
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v7i2.15444

Abstract

Background: The Citrus maxima plant is native to the Malay islands and East India. This plant grows widely in the tropics and has been widely used as medicine. Objectif: The purpose of this study was to study Citrus maxima from the aspect of phytochemical and pharmacological activity. Methods: The method used in this research is PRISMA systematic review. Sources of data obtained from electronic databases PubMed, Science Direct, and Google Scholar. Results: The results of a systematic review showed that the Citrus maxima plant contains naringin, hesperidin, hesperetin, rutin, nobiletin, tangeretin, vitamin C, limonene, lycopene, bergapten, umbelliferone and auraptene compounds. . Conclusion: These compounds have pharmacological activities as antioxidants, anticancer, antibacterial, anti-inflammatory, and antidiabetic
Inhibition of Human Epidermal Growth Factor Receptor-2 (HER-2) from Pomelo (Citrus maxima) Flavonoid Compounds: an In Silico Approach Mutiah, Roihatul; Dewi, Tanaya Jati Dharma; Suryadinata, Arief; Qonita, Kesimira
Indonesian Journal of Cancer Chemoprevention Vol 12, No 3 (2021)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev12iss3pp148-160

Abstract

Citrus maxima or pomelo is a plant that has potential as an anticancer because it contains flavonoids. One of the targets of breast anticancer receptors is the HER-2 protein. This research aims to determine the anticancer activity, the toxicity of the compound, and the prediction of physicochemical properties of flavonoids contained in Citrus maxima through in silico approach. Flavonoid compounds were screened using SwissADME with Lipinski's rule of five, Torsion, TPSA, and P-Gp Non-Substrate. Compounds that passed the screening were carried out molecular docking to the HER-2 receptor (PDB ID: 3PP0) using the Molegro Virtual Docker (MVD). The HER-2 receptor (GDP ID: 3PP0) was declared valid because it had RMSD<2Å. The results showed that there were 11 flavonoid compounds that passed the screening and had a lower rerank score than the comparison compound Trastuzumab. Toxicity was predicted using the Protox II online tool and the results showed that the flavonoid compounds were in the safe limits, namely classes 5 and 3. Based on this research, it can be concluded that acacetin, diosmetin, honyucitrin, isosinensetin, nobiletin, sinensetin, and tangeretin can be candidates for breast cancer drugs based on natural ingredients.Keywords: breast cancer, Citrus maxima, HER-2, in silico.
Co-Authors Arief Suryadinata Luthfi, Fitrati Hasanah Mutiah, M.Kes, Roihatul Roihatul Mutiah Tanaya Jati Dharma Dewi