Article Per Year (5 Year)
p-Index From 2020 - 2025
1.259
P-Index
This Author published in this journals
All Journal Indonesian Journal of Cancer Chemoprevention Journal of Islamic Pharmacy Jurnal Farmasi Sains dan Komunitas Journal of Islamic Medicine FITOFARMAKA: Jurnal Ilmiah Farmasi Bioscientist : Jurnal Ilmiah Biologi Journal of Halal Science and Research
Tanaya Jati Dharma Dewi
Universitas Islam Negeri Maulana Malik Ibrahim Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Other

Published : 7 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 7 Documents
Search

 1 
Standardization of Semanggi (Marsilea crenata C. Presl.) Leaves from Benowo District, Surabaya for Standardized Herbal Raw Material Burhan Ma'arif; Almay Abidzar Elpasha; Arief Suryadinata; Tanaya Jati Dharma Dewi; Novia Maulina; Mangestuti Agil
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 13, No 1 (2023): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v13i1.7459

Abstract

Semanggi (Marsilea crenata C. Presl.) is a unique plant that grows in East Java, Indonesia. Its leaves are widely used as ingredients for traditional food. Semanggi leaves contain phytoestrogen compounds that can be used for their antineuroinflammatory, antiosteoporosis, and antioxidant properties. This effect is believed to be caused by kaempferol as an active marker. This study aims to determine the specific and non-specific parameters of semanggi leaves from Benowo District of Surabaya. The standardization results for specific parameters revealed the macroscopic characteristics of the leaves in radius ± 2 cm, pale green to yellowish-green color, smooth surface, obdeltoid shape, and four leaves. The microscopic features are stomata on the epidermis, crystal sand calcium oxalate, bone leaves with vascular bundle, and no space between the epidermis. The organoleptic characteristics are yellowish-green color, tasteless, astringent smell. The physicochemical of water-soluble content result was 7.4566 ± 0.1173% and soluble ethanol was 7.7466 ± 0.4083%. The phytochemical positive test results for the identification of alkaloids, flavonoids, and terpenoids. Based on UHPLC-HRMS analysis, semanggi leaves contain 0,41% kaempferol with a retention time of 6.88 ± 0.2 minute. The results for non-specific parameters indicated that the content of total ash, acid-insoluble ash, moisture, and drying shrinkage content was 0.8136 ± 0.0171%; 7.9700 ± 0.1044%; 6.2547 ± 0.2864%; and 9.0936 ± 0.1305% respectively. The results indicate that the semanggi leaves sample have been assessed and found to meet the established standards.
Studi In Silico Senyawa Alkaloid dari Daun Sirsak (Annona muricata L.) Sebagai Inhibitor Angiotensin Converting Enzyme (ACE) Dewi, Tanaya Jati Dharma; Ariqoh, Salma Shafira; Wafi, Abdul
Journal of Islamic Pharmacy Vol 8, No 2 (2023): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v8i2.24829

Abstract

Hipertensi yang juga disebut sebagai penyakit tekanan darah tinggi merupakan peristiwa dimana terjadi peningkatan darah di dalam pembuluh darah arteri. Daun sirsak atau (Annona muricata L.) merupakan salah satu tumbuhan yang dipercaya memiliki potensi sebagai antihipertensi dengan terkandungnya senyawa alkaloid di dalamnya. Salah satu protein target dalam tubuh yang berhubungan dengan penyakit hipertensi adalah Angiotensin Converting Enzyme (ACE). Penelitian ini bertujuan untuk mengetahui prediksi aktivitas sebagai inhibitor ACE, prediksi fisikokimia, dan prediksi toksisitas dari senyawa alkaloid dari daun sirsak (Annona muricata L) secara in silico. Prediksi fisikokimia dilakukan dengan menggunakan aplikasi SwissADME dengan parameter hukum lima Lipinski. Senyawa alkaloid diketahui memenuhi parameter. Prediksi toksisitas dilakukan dengan menggunakan software Protox II online tool dan pkCSM online tool yang mengacu pada LD50 dan klasifikasi kelas toksisitas digolongkan menurut GHS, ames toxicity dan hepatotoxicity. Terdapat dua belas senyawa yang termasuk ke dalam kelas 4 (berbahaya bila tertelan yaitu 300
In Silico Study of Curcuminoid Compounds in Turmeric ( Curcuma longa) Plants as Halal Anticoagulant Active Ingredients Dewi, Tanaya Jati Dharma; Sya'bana, Mohammad Mohammad Ihda Faiz; Wafi, Abdul; Ma’arif, Burhan; Muchlasi, Luthfi Ahmad
Journal of Islamic Medicine Vol 7, No 2 (2023): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2023
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v7i2.24568

Abstract

Background:  Thrombosis is a condition when there is a reduction in the flow of blood fluid in the blood vessels that occurs due to the process of forming blood clots. One of the drugs most often used as an anticoagulant is enoxaparin. Enoxaparin itself is obtained by depolymerizing the base of heparin benzyl ester which is derived directly from the intestinal mucosa of pigs so that its use triggers a lot of controversy by Muslims. The mechanism of action of enoxaparin is to act as an antithrombin III catalyst which functions to inhibit the formation of blood clots by factor X. The curcumin compound in turmeric is known to have the ability as an anticoagulant drug by inhibiting the formation of factor Xa by factor X. Objectif :This study aims to predict physicochemical properties, predict toxicity, and predict the antiviral activity of 8 curcumin-derived compounds in turmeric against antithrombin III receptors (GDP ID: 1R1L) and factor X (GDP ID: 5VOF). Methods :Prediction of physicochemical properties is carried out using the SwissADME application and referring to Lipinski's five laws . Furthermore, the toxicity class was carried out using the pkCSM Online Tool and Protox Online Tool applications. Prediction of the antiviral activity of compounds was carried out using the Molegro Virtual Docker (MVD) application.Results:The results of the LD50 value and the classification of toxicity classes were classified according to GHS. 8 compounds derived from curcumin belong to toxicity classes 4 and 5. Antithrombin III receptors (GDP ID: 1R1L) and factor X (GDP ID: 5VOF were said to be valid because they had RMSD values below 2 Å. Conclusion :The results showed that cyclocurcumin compounds were predicted to have good potential anticoagulant activity.Background:  Thrombosis is a condition when there is a reduction in the flow of blood fluid in the blood vessels that occurs due to the process of forming blood clots. One of the drugs most often used as an anticoagulant is enoxaparin. Enoxaparin itself is obtained by depolymerizing the base of heparin benzyl ester which is derived directly from the intestinal mucosa of pigs so that its use triggers a lot of controversy by Muslims. The mechanism of action of enoxaparin is to act as an antithrombin III catalyst which functions to inhibit the formation of blood clots by factor X. The curcumin compound in turmeric is known to have the ability as an anticoagulant drug by inhibiting the formation of factor Xa by factor X. Objectif :This study aims to predict physicochemical properties, predict toxicity, and predict the antiviral activity of 8 curcumin-derived compounds in turmeric against antithrombin III receptors (GDP ID: 1R1L) and factor X (GDP ID: 5VOF). Methods :Prediction of physicochemical properties is carried out using the SwissADME application and referring to Lipinski's five laws . Furthermore, the toxicity class was carried out using the pkCSM Online Tool and Protox Online Tool applications. Prediction of the antiviral activity of compounds was carried out using the Molegro Virtual Docker (MVD) application.Results:The results of the LD50 value and the classification of toxicity classes were classified according to GHS. 8 compounds derived from curcumin belong to toxicity classes 4 and 5. Antithrombin III receptors (GDP ID: 1R1L) and factor X (GDP ID: 5VOF were said to be valid because they had RMSD values below 2 Å. Conclusion :The results showed that cyclocurcumin compounds were predicted to have good potential anticoagulant activity.
Formulasi Sabun Mandi Cair Berbasis Virgin Coconut Oil (VCO): Optimalisasi Pemanfaatan Produk Lokal Untuk Perawatan Kulit dan Pencegahan Dehidrasi Maulina, Novia; Muslikh, Faisal Akhmal; Nastiti, Ginanjar Putri; Fadilla, Rahma Nur; Winayah, Mesri Ananta; Kamelin, Badira; Firdaus, Natasya Octavia Putri; Fricananta, Salma Salsabila; Dewi, Tanaya Jati Dharma
Bioscientist : Jurnal Ilmiah Biologi Vol. 13 No. 1 (2025): March
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v13i1.14160

Abstract

Skin dehydration is a common issue affecting 40–50% of the adult population, resulting in dry, rough, and dull skin, as well as itching, irritation, and premature aging. The "back to nature" trend has increased interest in natural skincare products that are more environmentally friendly and gentler on the skin. Virgin coconut oil (VCO) is a popular natural ingredient known for its ability to maintain skin moisture and provide protection. This study aims to develop a liquid soap formulation using VCO to address skin dehydration. The research methods included formulation and evaluation of liquid soap through organoleptic testing, foam stability, specific gravity, pH, as well as hedonic and irritation tests. The results showed that: (1) Formula III met all physical evaluation parameters, including organoleptic characteristics, foam stability and height, specific gravity, and pH, in accordance with SNI standards; (2) Formula III was the most preferred by panelists in the hedonic test and caused no skin irritation based on irritation test results. Therefore, Formula III can be concluded as the optimal formulation for VCO-based liquid bath soap.
Inhibition of Human Epidermal Growth Factor Receptor-2 (HER-2) from Pomelo (Citrus maxima) Flavonoid Compounds: an In Silico Approach Mutiah, Roihatul; Dewi, Tanaya Jati Dharma; Suryadinata, Arief; Qonita, Kesimira
Indonesian Journal of Cancer Chemoprevention Vol 12, No 3 (2021)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev12iss3pp148-160

Abstract

Citrus maxima or pomelo is a plant that has potential as an anticancer because it contains flavonoids. One of the targets of breast anticancer receptors is the HER-2 protein. This research aims to determine the anticancer activity, the toxicity of the compound, and the prediction of physicochemical properties of flavonoids contained in Citrus maxima through in silico approach. Flavonoid compounds were screened using SwissADME with Lipinski's rule of five, Torsion, TPSA, and P-Gp Non-Substrate. Compounds that passed the screening were carried out molecular docking to the HER-2 receptor (PDB ID: 3PP0) using the Molegro Virtual Docker (MVD). The HER-2 receptor (GDP ID: 3PP0) was declared valid because it had RMSD<2Å. The results showed that there were 11 flavonoid compounds that passed the screening and had a lower rerank score than the comparison compound Trastuzumab. Toxicity was predicted using the Protox II online tool and the results showed that the flavonoid compounds were in the safe limits, namely classes 5 and 3. Based on this research, it can be concluded that acacetin, diosmetin, honyucitrin, isosinensetin, nobiletin, sinensetin, and tangeretin can be candidates for breast cancer drugs based on natural ingredients.Keywords: breast cancer, Citrus maxima, HER-2, in silico.
Production and characterization of halal-based gelatin derived from Red Nile Tilapia (Oreochromis niloticus) fishbone Rahmayanti, Mayu; Irsyadulibad, Mohamad; Dewi, Tanaya Jati Dharma; Firdausi, Amalia Salsa Billah; Megawati, Dewi Sinta; Jebreen, Ali
Journal of Halal Science and Research Vol. 6 No. 1 (2025): February
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jhsr.v6i1.11409

Abstract

Gelatin is one of the chemical products derived from protein hydrolysis. The demand for gelatin in Indonesia increases yearly, but domestic production still needs to meet the demand, leading to imports. International gelatin production statistics indicate that 58% is derived from pig skin, which is prohibited for Muslims. Therefore, this research aims to produce halal-based gelatin that meets quality standards. Red Nile Tilapia (Oreochromis niloticus) fishbones are used as the raw material for this study, as their halal status is clear in the Quran and Hadith. The fishbones are soaked in different concentrations of phosphoric acid, namely F1 (4%), F2 (6%), and F3 (8%), for 48 hours, then extracted using distilled water solvent in a water bath for 6 hours. The extracted solution is filtered, and the filtrate is dried in an oven at 50°C for 48 hours. The gelatin yield is statistically analyzed using correlation methods, and its functional groups are identified using FTIR spectroscopy. Compared to existing standards, gelatin characteristics are evaluated through organoleptic tests, such as pH, gel strength, viscosity, moisture content, and ash content. The gelatin yield for F1 is 8.15 ± 0.18%; F2 is 12.08 ± 0.12%, and F3 is 15.66 ± 0.26%. The research demonstrates that phosphoric acid concentration significantly influences gelatin yield, with higher concentrations resulting in higher yields. The FTIR spectra also indicate that the synthesized gelatin resembles commercial gelatin in spectra and absorption peaks. All gelatin variations meet the requirements for organoleptic properties, gel strength, moisture content, and ash content, while only F1 and F2 meet the pH requirements.   Keywords: FTIR, halal gelatin, Red Nile Tilapia (Oreochromis niloticus) fishbone.
Design, Formulation, and Evaluation of Vitamin C Tablets Using Co-Processed Excipient Combination of Jackfruit Seed Starch and Avicel®️ PH 101 Rahmayanti, Mayu; Dewi, Tanaya Jati Dharma; Aktifa, Ana Fadilia; Paramitha, Sella; Nikmah, Rahayu Hikmatul; Septianshar, Lumen Muzaidi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008319

Abstract

Tablet is a popular pharmaceutical dosage form among the public. One method of making tablets is direct compression. This method must consider the flow properties and compressibility of the excipients. But many excipients do not meet these criteria, leading to the alternative use of co-processed excipients of jackfruit seed starch and avicel®️ PH 101. This research aims to determine the physical characteristics of direct compression vitamin C tablets using co-processed excipient of PBN-A (Jackfruit Seed Starch and Avicel®️ PH 101) with varying ratios of 1:3, 3:1, and 1:1. The research methods include powder preparation, powder evaluation, tablet compression, and physical evaluation of tablet. Descriptive and statistical data analysis using one-way ANOVA. The research results show that tablets exhibit favorable physical characteristics in F1, but F2 and F3 show suboptimal hardness and friability values. The statistical analysis results indicate a significant difference with a p-value of (0.000) and post-hoc tests explain that these significant differences are particularly noticeable between F1 and F2, K1, and K2. This study concludes that vitamin C tablets using co-processed excipients of PBN-A with ratios of 1:3, 3:1, and 1:1 exhibit good physical characteristics in all evaluations, except for the hardness and friability of F2 (3:1) and the hardness of F3 (1:1).
Co-Authors Abdul Wafi, Abdul Aktifa, Ana Fadilia Almay Abidzar Elpasha Arief Suryadinata Ariqoh, Salma Shafira Burhan Ma&#039;arif Fadilla, Rahma Nur Faisal Akhmal Muslikh Firdaus, Natasya Octavia Putri Firdausi, Amalia Salsa Billah Fricananta, Salma Salsabila Ginanjar Putri Nastiti Irsyadulibad, Mohamad Jebreen, Ali Kamelin, Badira Mangestuti Agil Mayu Rahmayanti Ma’arif, Burhan Muchlasi, Luthfi Ahmad Nikmah, Rahayu Hikmatul Novia Maulina Paramitha, Sella Qonita, Kesimira Roihatul Mutiah Septianshar, Lumen Muzaidi Sya'bana, Mohammad Mohammad Ihda Faiz Winayah, Mesri Ananta