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All Journal Alchemy : Journal of Chemistry Indonesian Journal of Cancer Chemoprevention INDONESIAN JOURNAL OF PHARMACY Journal of Islamic Pharmacy Science and Technology Indonesia Jurnal Farmasi Sains dan Komunitas Journal of Islamic Medicine Pharmacology and Clinical Pharmacy Research Jurnal Tumbuhan Obat Indonesia

Roihatul Mutiah

Universitas Islam Negeri Maulana Malik Ibrahim Malang

Author-ID : 1168129

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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EKSTRAK ETANOL AKAR DAN DAUN DARI TANAMAN Calotropis gigantea AKTIF MENGHAMBAT PERTUMBUHAN SEL KANKER KOLON WiDr SECARA IN VITRO Mutiah, Roihatul; Widyawaruyanti, Aty; Sukardiman, Sukardiman
Journal of Islamic Pharmacy Vol 1, No 1 (2015): Jurnal Farmasains
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v1i1.4278

Penelitian ini bertujuan untuk mengetahui perbandingan aktivitas antikanker ekstrak etanol bagian akar, daun dan bunga dari tanaman Calotropis gigantea terhadap sel kanker kolon WiDr. Pengujian efek penghambatan pertumbuhan antikanker dilakukan dengan metode MTT. Hasil menunjukkan bahwa ekstrak etanol bagian akar dan daun Â Calotropis giganteaÂ mempunyai aktivitas antikanker terhadap sel kanker kolon WiDr yang lebih tinggi berturut turut dengan IC50 44.20 Î¼g/ml; 48.50 Î¼g/ml dibanding bagian bunga (IC50 3576 Î¼g/ml) sehingga bagian akar dan daun dapat direkomendasikan untuk uji lebih lanjut dalam pengembangan fitofarmaka.Kata kunci: Calotropis gigantea, WiDr cell line, anti kanker

PEMBERDAYAAN MASYARAKAT SUKU TENGGER NGADAS PONCOKUSUMO KABUPATEN MALANG DALAM MENGEMBANGKAN POTENSI TUMBUHAN OBAT DAN HASIL PERTANIAN BERBASIS â€œETNOFARMASIâ€ MENUJU TERCIPTANYA DESA MANDIRI Listiyana, Anik; Mutiah, Roihatul
Journal of Islamic Medicine Vol 1, No 1 (2017): Journal of Islamic Medicine
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Students as well as the next intellectual generation in society is not limited to academic obligations in the campus environment, but also should be useful in a variety of other functions in society. Students are also required to participate in community service through various forms of devotion. In this community service, lecturers with students to jointly work devotion in advancing knowledge and skills Tengger tribe in Ngadas Village District of Poncokusumo in developing the potential of medicinal plants and agricultural products based ethnopharmacy towards the creation of an independent village. Ngadas village is village with abundant natural resources, especially medicinal plants and agricultural products. Medicinal plants rare owned by the village is pronojiwo (Euchresta horsfieldii), pulosari (Alyxia reinwardtii), sintok (Cinnamomum sintoc), purwoceng (Pimpinella pruatjan), krangean (Litsea cububa Pers), flour muscles (Borreria laevis Griseb.), guava wer (Prunus persica Bl.), dringu (Acorus calamus L.). Medicinal plants have the potential to be developed and produced in large quantities in this village. Natural wealth of agricultural products is also very abundant in this village include potato, cassava, sweet potatoes and celery. But not taken into ready to eat foods products. Performed community service on 19 November 2016 in the village hall Ngadas. The activities carried out in the form of workshops begins with exposure of the material on the benefits and applications of potential medicinal plants that become local wisdom in Tengger tribe and then followed by demo making products. The product are rub medicine guava wer,Â muscle flour, starfruit herbal drinks and bajigur. Participants consisted of PKK Ngadas village. Good response shown by them with great enthusiasm when exposure of the material provided and when making products. In the future, this mentoring program to be developed into entrepreneurial activities of local communities to improve their welfare.

Studi Efikasi dan Keamanan Ekstrak Akar dan Daun Calotropis gigantea Terhadap Sel Kanker Kolon dan Sel Kanker Payudara Secara In Vitro Mutiah, Roihatul
Journal of Islamic Medicine Vol 1, No 2 (2017): Journal of Islamic Medicine
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Development of phytopharmaca for cancer until now has become a major step in overcoming the failure of cancer therapy. Calotrophis gigantea is one of the scientifically proven plants both in vitro and in vivo as a chemopreventive agent. This study aims to explain the efficacy and safety of Calotropis gigantea leaf extract (EDCG) and Calotropis gigantea root extract (EACG) on NIH3T3 cell, colon cancer cell WiDr and T47D breast cancer cells. From the analysis of MTT and Selectivity Index (SI) analysis showed that ethanol extract of leaf Calotropis gigantea (EDCG) can inhibit selective growth of selective colon cancer cells (SI 3) but not selective in inhibiting the growth of breast cancer cells T47D (SI 3 ). Calotropic gigantea (EACG) root ethanol extract is not selective in inhibiting the growth of colon cancer cells WiDr and breast cancer cells T47D (SI 3). Therefore EDCG can be recommended as a Phytopharmaca candidate with further proof through clinical trials.

FORMULATION AND CHARACTERIZATION OF SUNSCREEN MICROEMULSION OF PINEAPPLE EXTRACT (Ananas comosus (L.)) WITH SYNERGISTIC EFFICACY ON SUN PROTECTION FACTOR (SPF) Mutiah, Roihatul; Sukma, Yolanda Cahyaning; Megawati, Dewi Sinta; Annisa, Rahmi
Journal of Islamic Pharmacy Vol 4, No 1 (2019): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v4i1.7727

The root of Calotropis gigantea (thistle) is an Indonesian herb to treat cancer based on empirical and scientific evidences. The study aims to find out the infuence of ethanol extract of Calotropis gigantea root in inhibiting cancer cell growth of Mus musculus fibrosarcoma in vivo and to find out metabolite compound in the Calotropis gigantea root extract. The effect of cancer cell growth inhibition was tested on Mus musculus inducted with 7.12-dimetilbenz (Î±) antrasena (DMBA) and dose treatment of 50, 100 and 150 mg/Kg body weight. The metabolomic analysis on the root employs UPLC-QToF-MS/MS as a positive ESI ion source, the movement phase of water/acid mixture is 99.9/0.1 [v/v] and acetonitrile/formic acid was 99.9/0.1 [v/v] with gradient elution system and stationary phase of C18. The chromatogram was analyzed using Masslynx 4.1. The component identification was based on the m/z ratio measured in Masslynx and m/z counted in chemdraw. The result of the study showed that the Calotropis gigantea root extract with the dose of 50, 100 dan 150 mg/Kg body weight were able to increase the weight of fibrosarcoma mice and have a significant influence on caspase-3 expression with cell apoptosis index 24.3 %; 13.3 % and 12.3 % respectively. The result of metabolomic analysis showed 14 compounds found in the root extract. There are two major compounds: 4-Chlorobenzenethiol with the area 32.51% and N-[1-(Adamantan-1-yl) ethyl]-2-(1-piperidinyl)-4-quinazolinamine with the area 37.20%. They are indicated responsible for the anticancer activity of Calotropis gigantea root extract.Â Keywords: Calotropis gigantea, caspase-3, fibrosarcoma, metabolomic, UPLC-QToF-MS/MS

ANTICANCER ACTIVITIES AND METABOLITE FINGERPRINTING OF UPLC-QToF-MS/MS METHOD FROM Chrysanthemum cinerariifolium (Trev) Listiyana, Anik; Lestari, Nia Ayu; Irawati, Santia; Indrawijaya, Yen Yen Ari; Annisa, Rahmi; Bhagawan, Weka Sidha; Mutiah, Roihatul; Ma'arif, Burhan
Journal of Islamic Pharmacy Vol 4, No 1 (2019): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v4i1.7728

Chrysanthemum cinerariifolium (C. cinerariifolium) is an empirically proven medicinal plant that has anticancer activities. This study aimed to profile metabolites, and cytotoxic activity of root, leaf, stem, and root extracts C. cinerariifolium on T47D cells and to determine the correlation of metabolite content with cytotoxic activity. The metabolite profile was carried out using UPLC-QToF-MS / MS, and cytotoxic activity was carried out using the MTT method. The results obtained in the form of a chromatogram were processed with the application Masslynk so that a metabolite profile data obtained. The data is then analyzed statistically using Principal Component Analysis (PCA). The results obtained on metabolite profiling showed that there were differences in metabolite profiles in the roots, stems, leaves, and chrysanthemums. The characteristic compounds in the flower section are D - (-) - Morphine and in the leaf part of genistein Â and N - [(5-Chloro-1,2,3-thiadiazol-4-yl) methyl] -1- (2-isopropyl-4 -methyl-1,3-thiazol-5-yl) -N-methyl ethanolamine. The major compounds in the roots, stems, and leaves are Orphenadrine with successive percentages of 9.11%, 10.16%, and 3.24%, and the major compounds in the flower section are D - (-) - Morphine with a percentage of 10, 86%. Furthermore, the results of the cytotoxic activity test showed differences in anticancer cytotoxic activity in the parts of the flower, leaf, stem, and root of C. cinerariifolium. Besides, there is a relationship between the metabolite content and anticancer cytotoxic activity of each part of C. cinerariifolium. The higher the level of orphenadrine compounds in the plant, the higher the potential for anticancer.Â Keywords: C. cinerariifolium, UPLC-QToF-MS/MS, T47D cells.

CYTOTOXIC ACTIVITIES PROFILE OF PARASITE MANGO (Dendrophthoe pentandra) FROM VARIOUS AREAS IN INDONESIA AGAINST T47D BREAST CANCER CELLS AND NORMAL VERO CELL LINES Mutiah, Roihatul
Journal of Islamic Pharmacy Vol 4, No 1 (2019): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v4i1.7726

Indonesia has so many kinds of a parasite (mistletoe), one of them which has potential anticancer activity is mango parasite (Dendrophthoe pentandra). This research aimed at determining the cytotoxic activity profile of mango parasite leaves extracts from several locations in Indonesia against T47D and Vero cell lines. Mango parasite leaves obtained from 4 locations in Indonesia: Kediri, Pekalongan, Sumatra, and Kalimantan. Three samples was obtained from 3 different sub-districts in each locations. Cytotoxic activities of samples were performed by MTT assay method. The results of this study showed that there were differences between samples obtained from different locations, especially in cytotoxic activity and selectivity indexes of mango parasite leaves (D. pentandra) ethanol extract. D. pentandra obtained from Kalimantan has the most potential cytotoxic activity and could be potentially developed into a T47D breast anticancer agent. Extracts from the Kalimantan have an IC50 values of287.39 Î¼g/ml, LC50 798.28 Î¼g / ml and selectivity index 2.77, which means it was toxic to cancer cells but safe for Vero cell lines, and its selectively kills cancer cells rather than Vero cell lines. The result of this study could support D. pentandra to be developed as a new potential Fitofarmaka.

Comparison of Ethanol Extract from Roots, Leaves, and Flowers of Calotropis gigantea as Anticancer on T47D Breast Cancer Cell Lines Mutiah, Roihatul; Sukardiman, Sukardiman; Widyawaruyanti, Aty; Zulaikah, Siti
ALCHEMY Vol 5, No 1 (2016): ALCHEMY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

This research aims to find out the anticancer activity of ethanol extract from the roots, leaves, and flowers of Calotropis gigantea. This experiment was conducted by MTT method on T47D breast cancer cell line. The result showed that the root of Calotropis gigantea was more cytotoxic (IC50 89.76 Î¼g/mL) on T47D breast cancer cell line than the leaves (IC50 459.51 Î¼g/mL) and the flowers (IC501000). Based on the result, roots are potent to be chemotherapeutic agent, especially in breast cancer.

CYTOTOXIC ACTIVITY AND PHYSICOCHEMICAL PROPERTIES OF GENDARUSIN A-E COMPOUNDS ON ESTROGEN ALFA RECEPTORS (2JF9) Indrawijaya, Yen Yen Ari; Octavia, Nur Ika; Mutiah, Roihatul; Bhagawan, Weka Sidha; Ma'arif, Burhan
Journal of Islamic Pharmacy Vol 4, No 1 (2019): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v4i1.9037

Estrogen Alfa (ERÎ±) is a receptor used as the main marker to identify the presence of tumors in the breast.compounds Gendarusin A-E have anticancer activity by inhibiting the poliferation of cancer cells and inducing apoptosis. The purpose of this research are to predict the cytotoxic activity, physicochemical properties, and toxicity of the gendarusin A-E compound. The predictions of physicochemical properties were tested in compliance with the Five Lipinski Rules and the results of the ADME process (absorption, distribution, metabolism, and excretion) using the application pkCSM Online tool. Prediction of cytotoxic activity using Molegro Virtual Docker (MVD) by validating receptors and molecular docking. Cancer receptor protein used in Estrogen Alfa with PDB code 2JF9. Toxicity prediction using the Protox II Online tool. The results of this study indicate that the Gendarusin A-E compound didnâ€™t completed the Five Lipinski Rules. Gendarusin A-E compounds had activity against receptors Estrogen Alpha which is shown by the results of RMSD 2 and Gendarusin A compounds had the smallest Rerank Score of -70.9817 compared to other compounds. Gendarusin B compound had the highest LD50Â 1212 mg / kg and classified in grade 4.

PENGAMBANGAN SISTEM NANOSTRUCTURED LIPID CARRIER (NLC) DAUN Chrysanthemum cinerariifolium (Trev.) Vis DENGAN VARIASI KONSENTRASI LIPID Listiyana, Anik; Mutiah, Roihatul; Suyadinata, Arief; Salsabilla, Farida Rahma
Journal of Islamic Medicine Vol 4, No 2 (2020): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2020
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v4i2.9787

Ethanol extract 96% of Chrysanthemum cinerariifolium (Trev.) Vis leaves are proven to have anticancer activity. However, these compounds have low solubility in water and fat. To improve the bioavailability of preparations, the development of drug design in the form of Nanostructured Lipid Carrier (NLC) is carried out.The aim this study was to determine the effect of differences in lipid concentration of Monostearin and Oleic Acid in the formulation of the NLC system of Chrysanthemum cinerariifolium (Trev.) Vis leaves, which produced good physicochemical characteristics including organoleptic characteristics, pH, viscosity, particle size, and drug entrapment efficiency. Making is done using the High Shear Homogenization method. Organoleptic tests showed ideal results for the Nanostructured Lipid Carrier (NLC) system, the resulting pH values in formula 1 (7.0 Â± 0.12), formula 2 (6.7 Â± 0.17) and formula 3 (6.8 Â± 0.2)), the viscosity value of formula 1 (55.66 Â± 2.84 cPs), formula 2 (28.86 Â± 3.91 cPs), and formula 3 (28.57 Â± 16.85 cPs). Particle size of formula 1 (5530 Â± 320.47 nm), formula 2 (5337 Â± 671.44 nm) and formula 3 (4676 Â± 2215.75 nm)). The entrapment efficiency value of formula 1 drugs (33.55%), formula 2 (38.77%), formula 3 (83.75%). Based on the characterization result, the best formula was obtained at a lipid concentration of 10%, which was used for the formula of the NLC system of Chrysanthemum cinerariifolium (Trev.) Vis leaves for oral anticancer preparations

Metabolite Profiling of Eleutherine palmifolia (L.) Merr. By HPTLC-Densitometry and its Correlation with Anticancer Activities and In Vitro Toxicity Mutiah, Roihatul; Hadya, Chorida Muhjatul; Ma'arif Z.A, Burhan; Bhagawan, Weka Sidha; Annisa, Rahmi; Indrawijaya, Yen Yen Ari; Huwaida, Fadhila Isma; Ramadhani D.A., Ria; Susilowati, Retno; Taufik, Imam
Indonesian Journal of Pharmacy Vol 30 No 3, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Eleutherine palmifolia (L.) Merr. (E. palmifolia) is a plant that used as raw material for herbal medicines. The difference of growing location the medicinal plants affects the difference of metabolite content, It also affects the pharmacological activity and toxicity of the plant. This study aims to determine the profile of metabolites (metabolite fingerprinting), anticancer profiles, toxicity/safety profiles from several different regions in Indonesia for the purpose of authentication, efficacy, safety and quality control of these plants. Samples were sampled from 6 different locations in Indonesia, they were West Java, Central Java, East Java, East Borneo, Central Borneo, and South Borneo. Metabolite fingerprinting was determined by HPTLC-densitometry method, the profile of anticancer activity and toxicity was known by the MTT-ELISA method. The difference between metabolite fingerprinting, anticancer profile, toxicity/safety profile was analyzed by Principal Component Analysis (PCA) and Hierarchical Component Analysis (HCA). Whereas the relation between metabolite fingerprinting, anticancer profile, toxicity/safety profile was analyzed by Partial Least Square (PLS). The results of the metabolite profile analysis with PCA showed that E. palmifolia from 6 different locations gave different metabolite profiles and there were 3 metabolites that had a significant effect on cluster formation. samples are Rf 055, 059, and 044. The results of the HCA analysis showed that the 6 regions are in one cluster the same one. The analysis of PLS-DA showed that the metabolites for anticancer activity are found in Rf 059, 076, 093 and Rf 034. While the metabolites for toxicity are Rf 002, Rf 044 and Rf 059.

Co-Authors Abdul Hakim Ach. Nashichuddin Ahmad, Ananda Rizkia Azizah Amrulloh, Muhammad Firman Andiartama, Amanda Milano Anik Listiyana Anik Listyana Annisa, Rahmi Arief Suryadinata Aty Widyawaruyanti Begum Fauziyah Briliana, Malich Septi Diajeng Dhani Wijaya, Dhani Elok Kamilah Hayati Erna Susanti Fathia Faza Rahmadanita Ferry Sandra Habibah, Atiqoh Nur Hadya, Chorida Muhjatul Hariz, Muhammad Fawaz Huwaida, Fadhila Isma Indradewa, Rhian Irawati, Santia Janaloka, Nandana Adyuta Kirana, Farenza Okta Laily Nurul Azizah Lestari, Nia Ayu Ma'arif Z.A, Burhan Ma'arif, Burhan Ma'arif, Burhan Minggarwati, Trian Sidha Muhammad Zainuddin Mustofa, Muhammad Ragib Nafisah, Fika Sayyidatun Nurlaili Susanti Octavia, Nur Ika Purwaningsih, Fauziyah Eni Qonita, Kesimira Rahmi Annisa Ramadhani D.A., Ria Retno Susilowati Ria Ramadhani Dwi Atmaja Risma Aprinda Kristanti Sadli Syarifuddin Salsabila, Dhia Fadhilah Salsabilla, Farida Rahma Samah, Moh.Alfin Siti Zulaikah Sukardiman Sukma, Yolanda Cahyaning Suyadinata, Arief Tanaya Jati Dharma Dewi Taufik, Imam Ulfah, Jauza Weka Sidha Bhagawan Wirda Anggraini Yen Yen Ari Indrawijaya Zahiro, Syayida Roisatus

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