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All Journal Indonesian Journal of Cancer Chemoprevention Pendas : Jurnah Ilmiah Pendidikan Dasar
Angelina, Dhella
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Other

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PENERAPAN MODEL PEMBELAJARAN BERBASIS MASALAH MENGGUNAKAN MEDIA INTERAKTIF UNTUK MENINGKATKAN KETERAMPILAN MEMBACA PEMAHAMAN SISWA KELAS 5 SDN 17/I RANTAU PURI Salsabila, Kania; Angelina, Dhella; Sari, Silfiyana; Darmawan, Hanif; Destrinelli
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 9 No. 3 (2024): Volume 09 No. 03 September 2024.
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v9i03.15308

Abstract

Based on the pre-cycle scores, it is known that of the 26 students, only 6 students met the score > KKM (70) while 20 of them had the score < KKM (70). Based on the scores in cycle 1 of the love the earth material, that of the 26 students there were only 14 students who met the score > KKM (70) while 12 of them had the score < KKM (70). If examined carefully, this score of 70 is only obtained by a small number of students in the class. So if it is a percentage, it is very far below the specified percentage of total student completion, namely 70% of the total number of students. For this reason, it is very necessary to improve the deficiencies in cycle I learning through the implementation of cycle II actions. Based on the scores in cycle 2 of the love the earth material, that of the 26 students there were only 22 students who met the score > KKM (70) while 4 of them had the score < KKM (70).
Citrus Flavonoids from Citrus reticulata Peels Potentially Target an Autophagy Modulator, MAP1LC3A, in Breast Cancer Anggoro, Bayu; Kumara, Dennaya; Angelina, Dhella; Ikawati, Muthi
Indonesian Journal of Cancer Chemoprevention Vol 12, No 3 (2021)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev12iss3pp114-122

Abstract

Citrus flavonoids have been known for their vast biological activities including chemoprevention activities. However, the organic solvent extraction system limits its potential utilization. We recently adopted a hydrodynamic-cavitation method to extract citrus flavonoids from citrus peels. In this study we verified the high flavonoid content of the hydrodynamic-cavitation extract from Citrus reticulata peels and explore the potency of its citrus flavonoid contents as targeted chemoprevention agent for breast cancer by using bioinformatics. Based on a thin layer chromatography, the extract positively yielded high content of citrus flavonoids represented by hesperidin. The toxicity analysis by Protox II Online Tool revealed that hesperidin as the major citrus flavonoid in the extract was considered safe with a predicted LD50 of 12,000 mg/kg. We then further exploring citrus flavonoids’ capacity in targeting MAP1LC3A, a key protein in autophagy. UALCAN analysis validated that low expression of MAP1LC3A is associated with low survival rates in breast cancer patients. Limonin, hesperidin, narirutin, neohesperidine, and naringin are flavonoids from citrus peels that predicted to have inhibitory activity against Protein Kinase A (PKA), a negative upstream of MAP1LC3A, calculated by KNIME. Citrus flavonoids scoparone, cirsimaritin, 4',5,7-trimethoxyflavone, eupatorine, and hesperidin were also exhibit similar structure to an agonist of ATG4B, a protein that plays a role in MAP1LC3A activation. Furthermore, eupatorine, hesperidin, and cirsimaritin displayed a high affinity to ATG4B based on a molecular docking. We concluded that citrus flavonoids from citrus peels are safe to normal cells, and the citrus flavonoids potentially targets MAP1LC3A by inhibiting PKA and acting as ATG4B agonists. Thus, this extract-contained flavonoids from citrus peels is potential to be investigated further as a chemoprevention agent by inducing autophagy, especially for breast cancer.Keywords: Citrus reticulata, citrus flavonoid, autophagy, MAP1LC3A, breast cancer.
Co-Authors Anggoro, Bayu Darmawan, Hanif Destrinelli Destrinelli Kumara, Dennaya Muthi Ikawati Salsabila, Kania Sari, Silfiyana