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All Journal Jurnal Ners Journal of Language and Health Jurnal MedScientiae Jurnal Kedokteran Meditek
Marcel Antoni
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Jurnal MedScientiae

 1 
Gene Therapy Revolution: Recent Advances and Modern Biomedical Laboratory Techniques Antoni, Marcel; Susilowati, Rina Priastini
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3258

Abstract

Genetic therapy is a revolutionary innovation in the medical world that aims to treat or prevent diseases through the modification of the patient's genetic material. This literature review examines the latest advances in genetic therapy, including the biomedical laboratory techniques used. Techniques such as Polymerase Chain Reaction (PCR), DNA sequencing, CRISPR-Cas9, and Prime Editing have provided the ability to modify genes with high precision. Genetic therapy has shown success in various diseases, including monogenic genetic diseases such as hemophilia and Duchenne Muscular Dystrophy, as well as cancer through Chimeric Antigen Receptor T-cell (CAR-T) therapy. Additionally, research shows the potential of genetic therapy in addressing complex diseases such as cardiovascular disease and diabetes, as well as in regenerative treatment for degenerative diseases like Parkinson's. Despite being promising, challenges related to ethics, safety, and accessibility still need to be addressed. Case studies indicate that although there are many successes, there are still obstacles to be overcome to improve the effectiveness and safety of this therapy. This literature review concludes that genetic therapy has great potential to become an important pillar of modern treatment in the future, provided that further research and development are needed to overcome the various existing barriers.
Pengaruh Kualitas Tidur terhadap Siklus Menstruasi Mahasiswi Angkatan 2023 Program Studi Sarjana Kedokteran Tan Shi Wei; Antoni, Marcel; Rumiati, Flora; Heriyanto, Heriyanto; Rickie, Rickie
Jurnal MedScientiae Vol. 4 No. 3 (2025): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v4i3.4020

Abstract

Sleep quality plays an essential role in maintaining overall health, including the proper function of the reproductive system, which is influenced by sex hormones and circadian rhythm regulation. Medical students frequently encounter high academic demands that may disrupt their sleep patterns. Previous research has suggested a possible association between sleep quality and menstrual cycle characteristics; however, findings have been inconsistent. This study aimed to examine the relationship between sleep quality and menstrual cycle regularity among female medical students from the 2023 at the Faculty of Medicine, Universitas Kristen Krida Wacana. A descriptive-analytic design with a cross-sectional approach was applied. Data were obtained through total sampling in November 2024 using the Pittsburgh Sleep Quality Index (PSQI) questionnaire to assess sleep quality and a self-reported menstrual cycle history. Of 67 respondents who met the inclusion and exclusion criteria, 51 (76.2%) reported poor sleep quality, while 16 (23.8%) had good sleep quality. Furthermore, 40 participants (59.7%) had normal menstrual cycles, and 27 (40.3%) reported irregular cycles. Statistical analysis revealed no significant association between sleep quality and menstrual cycle regularity (p = 0.794) among these students.
Analisis Pengaruh Jenis Air Terhadap Pembusukan Daging Sapi Untuk Memperkirakan Waktu Kematian Seseorang Irab, Imelda Margaretha; Yen, Liauw Djai; Hartono, Budiman; Antoni, Marcel
Jurnal MedScientiae Vol. 5 No. 1 (2026): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v5i1.4208

Abstract

Decomposition is a natural process that occurs as soon as the physiological functions of the body cease, at a rate that is influenced by the condition of the body and the environment in which it is located.  This study is a descriptive experimental study with a cross-sectional approach that aims to describe the effect of different types of water media, namely fresh water, brackish water, and sea water, on the process of beef spoilage. Air media was used as a comparison control group. The results showed that beef spoilage took place fastest in brackish water media, followed by fresh water, sea water, and slowest in closed air media. Decomposition in closed air media is inhibited due to low humidity, which triggers desiccation and natural mummification. The remaining connective tissue underwent slower decomposition due to the structural stability of collagen which is more resistant to enzymatic degradation. Different types of media significantly affected the rate of beef spoilage, in the order of fastest in brackish water, followed by freshwater, seawater, and slowest in closed air. This finding shows that the old rule of thumb does not always apply, because the rate of spoilage is more determined by environmental characteristics, especially salinity, pH, and water activity that affect the process of autolysis and tissue degradation.  
Co-Authors Budiman Hartono Calysta N Wijaya Flora Rumiati Glenn J Sumadi Heriyanto Heriyanto Hermawan, Stepanus Maman Ida Ayu Putu Sri Widnyani Indriani Kurniadi Sumadikarya Irab, Imelda Margaretha Paulus AA Pandelaki Rickie, Rickie Satriabudi, Mirza Indrajanti Stephanus Taniwidjaja Steven Sakasamita Suparto Suparto Susilowati, Rina Priastini Tan Shi Wei William William Willian, William Yanto S Tjang Yasavati Kurnia MS Yen, Liauw Djai