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All Journal Jurnal Ners Journal of Language and Health Jurnal MedScientiae Jurnal Kedokteran Meditek
Marcel Antoni
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Jurnal MedScientiae

 1 
Gene Therapy Revolution: Recent Advances and Modern Biomedical Laboratory Techniques Antoni, Marcel; Susilowati, Rina Priastini
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3258

Abstract

Genetic therapy is a revolutionary innovation in the medical world that aims to treat or prevent diseases through the modification of the patient's genetic material. This literature review examines the latest advances in genetic therapy, including the biomedical laboratory techniques used. Techniques such as Polymerase Chain Reaction (PCR), DNA sequencing, CRISPR-Cas9, and Prime Editing have provided the ability to modify genes with high precision. Genetic therapy has shown success in various diseases, including monogenic genetic diseases such as hemophilia and Duchenne Muscular Dystrophy, as well as cancer through Chimeric Antigen Receptor T-cell (CAR-T) therapy. Additionally, research shows the potential of genetic therapy in addressing complex diseases such as cardiovascular disease and diabetes, as well as in regenerative treatment for degenerative diseases like Parkinson's. Despite being promising, challenges related to ethics, safety, and accessibility still need to be addressed. Case studies indicate that although there are many successes, there are still obstacles to be overcome to improve the effectiveness and safety of this therapy. This literature review concludes that genetic therapy has great potential to become an important pillar of modern treatment in the future, provided that further research and development are needed to overcome the various existing barriers.
Pengaruh Kualitas Tidur terhadap Siklus Menstruasi Mahasiswi Angkatan 2023 Program Studi Sarjana Kedokteran Tan Shi Wei; Antoni, Marcel; Rumiati, Flora; Heriyanto, Heriyanto; Rickie, Rickie
Jurnal MedScientiae Vol. 4 No. 3 (2025): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v4i3.4020

Abstract

Sleep quality plays an essential role in maintaining overall health, including the proper function of the reproductive system, which is influenced by sex hormones and circadian rhythm regulation. Medical students frequently encounter high academic demands that may disrupt their sleep patterns. Previous research has suggested a possible association between sleep quality and menstrual cycle characteristics; however, findings have been inconsistent. This study aimed to examine the relationship between sleep quality and menstrual cycle regularity among female medical students from the 2023 at the Faculty of Medicine, Universitas Kristen Krida Wacana. A descriptive-analytic design with a cross-sectional approach was applied. Data were obtained through total sampling in November 2024 using the Pittsburgh Sleep Quality Index (PSQI) questionnaire to assess sleep quality and a self-reported menstrual cycle history. Of 67 respondents who met the inclusion and exclusion criteria, 51 (76.2%) reported poor sleep quality, while 16 (23.8%) had good sleep quality. Furthermore, 40 participants (59.7%) had normal menstrual cycles, and 27 (40.3%) reported irregular cycles. Statistical analysis revealed no significant association between sleep quality and menstrual cycle regularity (p = 0.794) among these students.
Co-Authors Calysta N Wijaya Flora Rumiati Glenn J Sumadi Heriyanto Heriyanto Hermawan, Stepanus Maman Ida Ayu Putu Sri Widnyani Indriani Kurniadi Sumadikarya Paulus AA Pandelaki Rickie, Rickie Satriabudi, Mirza Indrajanti Stephanus Taniwidjaja Steven Sakasamita Suparto Suparto Susilowati, Rina Priastini Tan Shi Wei William William Willian, William Yanto S Tjang Yasavati Kurnia MS