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All Journal JKPK (Jurnal Kimia dan Pendidikan Kimia) AJARCDE (Asian Journal of Applied Research for Community Development and Empowerment) Jurnal Pijar MIPA Folia Medica Indonesiana
Arizandy, Radita Yuniar
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Energy Environmental Science Health Professions Mathematics Medicine & Pharmacology Neuroscience Physics

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Antibacterial Potential of Single Black Garlic Extract Organosulfur Compounds on Staphylococcus aureus Bacteria Destiana, Rindy Tya; Herdyastuti, Nuniek; Setyarini, Wahyu; Arizandy, Radita Yuniar
Jurnal Pijar Mipa Vol. 20 No. 4 (2025): Special Issue
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v20i4.9002

Abstract

Single black garlic (SBG) is a product of processing garlic (Allium sativum L.) by heating it for several days. SBG has antibacterial activity due to the presence of organosulfur, phenolic and flavonoid compounds. This research aims to determine the antibacterial potential of SBG extract on Staphylococcus aureus and determine its chemical compound content based on Liquid Chromatography-Mass Spectrometer (LC-MS) analysis. The extract was obtained from the maceration method combined with a magnetic stirrer using 0, 30, 60 and 90% ethanol solvent. The antibacterial test used the disc diffusion method with a positive control of ciprofloxacin and a negative control of distilled water. LC-MS analysis of SBG extract with the best antibacterial activity. The results of the antibacterial activity test showed that the SBG extract had antibacterial activity based on the presence of an inhibition zone. The largest zone of inhibition in the 90% ethanol solvent SBG extract was 27.71 mm, and the positive control was 22.58 mm. The SBG extract with the most optimal antibacterial activity was analyzed using LC-MS to produce 109 compounds which were divided into 15 different compound groups, some of which were allicin (5.900%) which was the compound with the most composition and innulotetraose (0.065%) which was the compound with the smallest composition in the SBG extract. Data from the antibacterial test results were processed using the IBM statistical program SPSS 25, a One-way ANOVA test, which aims to determine the effect of antibacterial activity on Staphylococcus aureus bacteria, and data on the chemical compound content of the SBG extract were analyzed descriptively. SBG extract has the potential as an antibacterial which is classified as very strong in-vitro, so further in-vivo research is needed to apply the extract as an economical product that can treat skin infections and there are several compounds that dominate SBG extract with the highest antibacterial activity, such as organosulfur compounds, amino acids, flavonoids and phenolics based on LC-MS analysis.
The Shelf-Life Prediction of Black Garlic Chili Sauce and “Cahyo” Garlic Chili Sauce with Accelerated Shelf-Life Testing (ASLT) Method Based on The Arrhenius Model Indra Purnama, Afridho Laksono; Yulistiani, Ratna; Agung Wicaksono, Luqman; Setyarini, Wahyu; Arizandy, Radita Yuniar; Putri Febrianti, Nadya Dwi
AJARCDE (Asian Journal of Applied Research for Community Development and Empowerment) Vol. 7 No. 1 (2023)
Publisher : Asia Pacific Network for Sustainable Agriculture, Food and Energy (SAFE-Network)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29165/ajarcde.v7i1.227

Abstract

Sambal is often found in various menu variants served in the Indonesian food industry; this is a supporting factor for creating bottled chili sauce. In this research, fermented black garlic chili sauce was made with black garlic as raw material to provide added value in the form of antibacterial and antioxidant compounds, as well as giving a novelty value to the product as well as a differentiator in the elements of color, aroma, consistency, and taste of the product. The final product consumers receive is compared to "Cahyo" garlic chili sauce produced by PT. Deltasari Indah Restaurant. Sambal contains oil/fat, which is quickly rancid, thus affecting the element of consumer acceptance. Therefore, it is necessary to predict the shelf life of bottled chili products. This research aims to predict the shelf life of the black garlic chili sauce and “Cahyo” garlic chili sauce products in bottles produced by PT. Deltasari Indah Restaurant with the ASLT method, the Arrhenius model approach; Knowing the difference in the shelf life of bottled chili products stored at different temperature conditions; and determining the proper temperature and storage conditions to get the maximum shelf life for packaged chili products. This study uses the Accelerated Shelf-Life Testing method with the Arrhenius model. Based on the pH value parameter, the shelf life of black garlic chili sauce was 33 days, and “Cahyo” garlic chili sauce was 45 days. These two results are the results of the shelf life obtained from calculations at 20?C and 25?C then the average value is taken.
The Carrier Rate of Extended Spectrum Beta Lactamase (ESBL) Producing Bacteria in Cockroaches (Periplaneta americana) in Hospital and Community Puspita, Ardhiya; Arizandy, Radita Yuniar; Wasito, Eddy Bagus; , Kuntaman
Folia Medica Indonesiana Vol. 57, No. 4
Publisher : Folia Medica Indonesiana

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Abstract

Highlight:• Bacteriologically for colonization of ESBL producing Enterobacteriaceae in cockroaches (Periplaneta americana) were analyzed. • The prevalence of ESBL producing bacteria among cockroaches in hospitals is bigger than in households. Abstract: Cockroach (Periplaneta americana) is one of the vectors in the environment that can transmit disease. Cockroaches can act as potential mechanical vectors of antibiotic resistant bacteria. Enterobacteriaceae is a gram-negative bacteria that has natural habitats in the digestive tract of humans and animals. Enterobacteriaceae that produce Extended Spectrum β-lactamases (ESBLs) have emerged as major pathogens in hospitals. The study analyzed the prevalence of ESBL producing bacteria in cockroaches that lived in hospitals and residential homes. In this study, a total of 200 cockroaches consisting of 100 cockroaches from the hospital environment and 100 cockroaches from the residential environment were analyzed bacteriologically for colonization of ESBL producing Enterobacteriaceae. The specimen of the alimentary tract was taken and sub-cultured in MacConkey agar supplemented with cefotaxime 2 ug/ml. Growth colonies were suggested as an ESBL-producing bacteria, then were confirmed as ESBL producers by the Double Disk Synergy Test (DDST). The ESBL gene was detected by Polymerase Chain Reaction (PCR). Among 100 household cockroach samples, 14 (14%) were identified as ESBL producers, while 100 hospital cockroaches were 26 (26%) positive ESBL. The ESBL gene, in hospital cockroach were identified of CTXM 19 (19%), SHV 7 (7%), and not any TEM gene, while among household cockroaches were identified CTXM 2 (2%), SHV 11 (11%), and also not detected TEM ESBL gene. Among ESBL genes, only the CTXM gene was significantly different between household and hospital cockroaches.
Green Synthesis of Copper Nanoparticles Using Gynura procumbens Leaf Extract as a Bioreductant and Their Antibacterial Activity Against Escherichia coli Rivana, Nancy; Sutoyo, Suyatno; Arizandy, Radita Yuniar; Setyarini, Wahyu
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 11, No 1 (2026): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v11i1.116736

Abstract

Copper nanoparticles (CuNPs) are nanomaterials extensively utilized in optics, electronics, biology, catalysis, and as antibacterial agents. Sustainable synthesis approaches employing plant-derived bioreductants have garnered significant attention. In this study, CuNPs were synthesized via green chemistry using Gynura procumbens leaf extract as a bioreductant. Synthesis was performed by combining the leaf extract with 0.1 M CuSO₄ solution at volume ratios of 1:1, 1:2, 1:3, and 1:4. The mixture with the optimal volume ratio was further optimized at pH values of 8, 9, 10, and 11. The resulting CuNPs were characterized by UV-Vis spectroscopy, FTIR, and PSA. Antibacterial activity against Escherichia coli (ATCC 25922) was evaluated using the disk diffusion method. Optimal synthesis was achieved at a 1:2 volume ratio and pH 8. The CuNPs exhibited a maximum UV-Vis absorption at 316 nm, an average particle size of 8.23 nm, and a polydispersity index of 0.1631. FTIR spectra confirmed Cu–O bond vibrations at 457.64 and 617.14 cm-1. The synthesized CuNPs demonstrated strong antibacterial activity against E. coli, with an inhibition zone diameter of 13.89 ± 0.45 mm. These findings suggest that CuNPs synthesized via green methods using G. procumbens extract as a bioreductant have potential as antibacterial agents, particularly against E. coli.
Co-Authors , Kuntaman Agung Wicaksono, Luqman Destiana, Rindy Tya Eddy Bagus Wasito Indra Purnama, Afridho Laksono Nuniek Herdyastuti Puspita, Ardhiya Putri Febrianti, Nadya Dwi Ratna Yulistiani Rivana, Nancy Setyarini, Wahyu Sutoyo, Suyatno