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All Journal Solo Journal of Anesthesi, Pain and Critical Care Folia Medica Indonesiana
Melbiarta, Rezy Ramawan
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Analysis of Spatial Working Memory Using the Y-Maze on Rodents Treated with High-Calorie Diet and Moderate-Intensity Exercise Melbiarta, Rezy Ramawan; Kalanjati, Viskasari P.; Herawati, Lilik; Salim, Yusuf; Othman, Zulhabri
Folia Medica Indonesiana Vol. 59, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: • This article reports the use of the Y-maze as a simple yet effective method to measure spatial working memory in mice. • The Y-maze method can be used safely without exposing the animals to additional stressors, as evidenced by the absence of mortality following the test. Abstract: Spatial working memory (SWM) in humans and animal models with impaired cognitive functions has been analyzed through a number of methods. However, this is still understudied in animal models treated with a high-calorie diet (HCD) and moderate-intensity exercise (MIE). The Y-maze was utilized as the assessment method in this study. A 40 x 9 x 9 cm3 Y-maze was employed to observe the animal models' spontaneous alternation (SA) as the representation of their SWM. This was done by calculating the total alternation percentage divided by total entry minus two. A total of 17 female Mus musculus mice aged 8 weeks were tested in the Y-maze to investigate their SWM using SA calculations. Each mouse was analyzed for eight minutes and recorded in a dark and quiet room to minimize bias due to environmental noise and lighting. Comparing the treatment group's (HCD+MIE) SA to the control group's SA revealed no statistically significant difference (p=0.451). Seven mice in the treatment group performed similarly to the mice in the control group in the Y-maze test, with no significant difference in their ability to complete the task. The mice in the treatment group exhibited no motor impairment, as indicated by complete movements of all their extremities while exploring the Y-maze within the allotted time. In conclusion, the Y-maze can be used as a reliable method to analyze SWM in overweight/obese Mus musculus animal models treated with moderate-intensity physical exercise.
From Scene to Emergency Department: Is Delta Shock Index a Reliable Predictor in Trauma Care? A Meta-Analysis Aurelia, Cherryl; Alverina, Clara; Melbiarta, Rezy Ramawan; Edwar, Pesta Parulian Maurid
Solo Journal of Anesthesi, Pain and Critical Care (SOJA) Vol 5, No 2 (2025): October 2025
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/soja.v5i2.106534

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Background: Trauma is a leading global cause of morbidity and mortality, with hemorrhage being a highly preventable cause of death. Delta SI (dSI), reflecting time-dependent hemodynamic changes, shows promise, though conflicting data necessitate comprehensive evaluation of its predictive superiority. This study, therefore, aims to assess the diagnostic accuracy of dSI in predicting clinical outcomes among trauma patients.Methods: This systematic review and meta-analysis included eight studies (Jan 2015–Jul 2025) on adult trauma patients evaluating dSI (Emergency Department SI – prehospital SI) for mortality, blood transfusion needs, or Intensive Care Unit (ICU) admission. Searches were conducted across ScienceDirect, PubMed, Scopus, and Taylor & Francis. The risk of bias was assessed using the QUADAS-2.Results: Eight studies (931,954 patients) were included. DSI consistently showed low sensitivity but high specificity. For blood transfusion, sensitivity was 0.411 (0.313–0.517) and specificity was 0.873 (0.802–0.921). For mortality, sensitivity was 0.350 (0.259–0.454) and specificity was 0.821 (0.763–0.867). ICU admission had a sensitivity of 0.21 (0.144–0.298) and a specificity of 0.887 (0.843–0.919). Subgroup analysis of massive transfusion and in-hospital mortality analyses also showed similar trends.Conclusion: Our findings highlight that while DSI demonstrates consistently high specificity across key clinical outcomes—including mortality, transfusion needs, and ICU admission—it suffers from limited sensitivity. However, its optimal utility lies in its integration with comprehensive clinical assessment rather than standalone use.
Co-Authors ALVERINA, CLARA Aurelia, Cherryl Edwar, Pesta Parulian Maurid HERAWATI, LILIK Othman, Zulhabri Salim, Yusuf Viskasari P. Kalanjati