Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Gema Wiralodra Jurnal Riset Kefarmasian Indonesia
Puspitasari, Ranny
Unknown Affiliation
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Nanopartikel ekstrak etil asetat daun melinjo (gnetum gnemon l.) dengan aktivitas antioksidan dan antibakteri terhadap propionibacterium acnes Puspitasari, Ranny; Rahmat, Deni; Djamil, Ratna
Gema Wiralodra Vol. 14 No. 1 (2023): Gema Wiralodra
Publisher : Universitas Wiralodra

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31943/gw.v14i1.367

Abstract

Melinjo (Gnetum gnemon L) mengandung asam askorbat, tokoferol, dan polifenol (fenol sederhana, flavonoid, dan tanin. Senyawa kimia ekstrak G. gnemon diperoleh tiga senyawa yaitu 3,4-dimethoxychlorogenic acid, resveratrol, dan 3-methoxyresveratrol. Daun G. Gnemon memiliki potensi antioksidan dan antibakteri. Tujuan penelitian ini membuat ekstrak dan nanopartikel ekstrak daun G, gnemon, serta mengetahui aktivitas antioksidan, antibakteri terhadap bakteri Propionibacterium acnes. Ekstraksi dilakukan dengan metode kinetik dengan pelarut etil asetat. Metode yang digunakan untuk pembuatan nanopartikel yaitu metode gelasi ionik dengan kitosan-Na TPP. Uji aktivitas antioksidan dengan metode DPPH dan uji akstivitas antibakteri menggunakan metode difusi cakram. Hasil menunjukkan ekstrak daun G gnemon memiliki aktivitas antioksidan lebih baik dibandingkan nanopartikel ekstrak daun G gnemon dimana nilai IC50 masing-masing sebesar 35,602 dan 55,105 ppm. Sedangkan untuk aktivitas antibakteri nanopartikel ekstrak G gnemon lebih kuat dibandingkan ekstrak daun G gnemon dimana zona hambat sebesar 12,3 mm. Analisis data dengan uji Mann-Whitney menunjukkan nilai Asymp Sig (2-tailed) < 0,05 terdapat perbedaan yang signifikan. Ukuran partikel Nanopartikel ekstrak daun G. gnemon yaitu (419,4 mm), indeks pendispersi (0,572%) dan potensi zeta (-68,5 9 mV). Ukuran nanopartikel memenuhi syarat karena <1000 mm
FORMULASI SEDIAAN DEODORAN SPRAY EKSTRAKDAUN MANGKOKAN (Polyscias scutellaria (Burm.f.) Fosberg) DAN UJI EFEKTIVITAS ANTIBAKTERI Staphylococcus epidermidis Huzaemah, Salma Haninah; Setiawan, Agus; Puspitasari, Ranny
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 2 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i2.525

Abstract

The mangkokan plant (Polyscias scutellaria (Burm.f.) Fosberg) has properties as a diuretic, anti-inflammatory, breast inflammation, swelling and promotes milk production. Mangkokan leaves have antibacterial activity against bacteria that cause body odor. The purpose of this study was to determine the formulation and effectiveness of the antibacterial deodorant spray of mangkokan leaf extract (Polyscias scutellaria (Burm.f.) Fosberg) against Staphylococcus epidermidis bacteria ATCC 12228. The type of research used is in-vitro experimental. Mangkokan leaf extract is formulated in the form of a deodorant spray with a concentration of 10%, 15% and 20%. Preparation evaluation includes organoleptic, pH and viscosity tests. Antibacterial activity testing was carried out in-vitro using the disc diffusion method against S. epidermidis bacteria ATCC 12228. The results showed that the secondary metabolites contained in mangkokan leaves (Polyscias scutellaria (Burm.f.) Fosberg) were alkaloids, flavonoids, saponins, tannins and terpenoids. Mangkokan leaf extract spray deodorant preparation (Polyscias scutellaria (Burm.f.) Fosberg) can inhibit the growth of Staphylococcus epidermidis bacteria ATCC 12228 shown at a concentration of 20% with an average inhibition zone of 7.06 mm in the medium category. Preparation of deodorant spray for mangkokan leaf extract (Polyscias scutellaria (Burm.f.) Fosberg) with a concentration of 10%, 15% and 20% according to the requirements of SNI 16-4951-1998 namely organoleptic test, pH test, spray pattern, but does not meet the homogeneity requirements because there are extract granules. The results of data analysis using Kruskal Wallis obtained Asymp.Sig 0.015 (Sig. <0.05) which means that they reject H0 and accept H1. There was also a significant difference between F1 and the positive control.  
Co-Authors Agus Setiawan Djamil, Ratna Huzaemah, Salma Haninah RAHMAT, DENI