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Aktivitas Fraksi Air Kulit Batang Mahoni (Swietenia macrophylla King.) dan Studi In Silico Senyawa Kimia Penghambat Enzim Î±-Glukosidase Khaerunnisa, Arini; Djamil, Ratna; Sulastri, Lilik; Simanjuntak, Partomuan
Jurnal Fitofarmaka Indonesia Vol 9, No 1 (2022): JURNAL FITOFARMAKA INDONESIA
Publisher : Jurnal Fitofarmaka Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v9i1.800

Â Inhibition of the Î±-glucosidase can be used as antidiabetic therapy because it can reduce postprandial blood sugar levels. The stem bark of mahogany (Swietenia macrophylla King.) have properties as inhibitors of enzyme Î±-glucosidase. The purpose of this study was to determine the active compound of mahogany stem bark against Î±-glucosidase enzyme in vitro and in silico. 96% ethanol extract of mahogany stem bark was partitioned with n-hexane, ethyl acetate and water. Testing of inhibition of Î±-glucosidase enzyme work done with substrate p-nitrophenyl-Î±-D-glucopyranoside. The water fraction was separated on silica gel column chromatography (SiO2 : dichloromethane-methanol = 10 : 1 ~ 1 : 1 and methanol). Molecular docking using AutoDock 4.2.6 was performed to predict the binding modes of Î±-glucosidase enzyme with chemical compound from water subfraction of stem bark mahogany. The results showed that water fraction of stem bark mahogany have antidiabetic activity with IC50 value of 1.51 Âµg/mL. Fraction Fr-1 gave an inhibition of 83.61 Â± 1.11 %. Fr-1 contains chemical compound catechin, evodionol, swietenitin E, 11-deoxyswienialide D, swietenitin J and H. In silico study showed that catechin and evodionol free energy value (Î”G) -6.98 and -6.25 Kcal/mol and inhibition constanta (Ki) 7.61 and 26.18 ÂµM.

Pembinaan Santri Pondok Pesantren Minhajusshobirin Untuk Penerapan Cara Produksi Pangan Olahan yang Baik Pada Produksi Minuman Belimbing Wuluh Rendah Kalori Novi Yantih; Faizatun, Faizatun; Djamil, Ratna; Qodriah, Rahmatul; Zaidan, Sarah
SULUH: Jurnal Abdimas Vol 4 No 2 (2023): SULUH: Jurnal Abdimas Februari
Publisher : FEB-UP Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/suluh.v4i2.4144

Abstract The students at the Minhajusshobirin Islamic Boarding School have produced a wuluh start fruit drink. Their drink has a high sugar content, so it cannot be consumed by diabetics. In addition, the product has not been certified, so it cannot be marketed widely. The purpose of this Community Service Program is to provide training for students to 1) Improve the skills of the students in good processed food production methods (good manufacturing practices/GMP), especially in producing wuluh star fruit drinks, 2) Increase the competitiveness of wuluh star fruit drink products by using sweeteners, low calories using stevia, and 3) Product stability test facilitation. The methods used in this activity included: licensing, surveys, counselling, training, laboratory testing, coaching, monitoring-evaluation, and publication of activity results. Measuring tools to assess the increase in knowledge and skills of students in the application of GMP in making low-calorie drinks are through questionnaires and direct surveys, as well as through product stability tests according to SNI 3719: 2014 standards in the QLab laboratory of the Faculty of Pharmacy, Universitas Pancasila. Training and supervision on GMP for processed food on sanitation and hygiene parameters have been given by a team of lecturers from the Faculty of Pharmacy, Universitas Pancasila. The quality assessment of the low-calorie drinks produced can be seen from the increase in product stability time of the test results in the laboratory. The pre-test and post-test results showed an increase in student understanding by 18.24%, which can be concluded that the training was effective. This activity is expected to be useful as an entrepreneurial provision for students when they serve in the community. Keywords: Universitas Pancasila, GMP, wuluh starfruit

Formulasi dan Uji Aktivitas Antioksidan Krim Kombinasi Ekstrak Biji Kopi Hijau (Coffea canephora var Robusta) dan Ekstrak Daun Teh Hijau (Camellia sinensis (L.)) Lamsari, Lamsari; Taurhesia, Shelly; Djamil, Ratna
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol 10, No 2 (2023): October
Publisher : Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v10i2.5082

Kopi robusta mengandung senyawa alkaloid, flavonoid, saponin, tanin, kafein dan fenol, sedangkan daun teh hijau mengandung senyawa katekin. Senyawa fenol pada kopi dan katekin pada daun teh hijau memiliki aktivitas sebagai antioksidan. Penelitian ini bertujuan untuk mengembangkan formulasi krim dari kombinasi ekstrak biji kopi hijau dan daun teh hijau, yang memiliki aktivitas antioksidan. Biji kopi hijau diekstraksi secara maserasi kinetik menggunakan pelarut kombinasi Isopropanol : air (60:40) sedangkan daun teh hijau diekstraksi dengan pelarut Etanol 70%. Setelah diperoleh ekstrak kental, kemudian dilakukan uji mutu ekstrak serta uji aktivitas antioksidan menggunakan metode DPPH. Nilai IC50 ekstrak biji kopi hijau (EBKH) adalah 22.37 ppm, ekstrak daun teh hijau (EDTH) adalah 7.02 ppm, sedangkan kombinasi EBKH : EDTH (1:1) adalah 11.59 ppm. Kemudian dikembangkan formula krim mengandung kombinasi kedua ekstrak dengan variasi perbandingan EBKH : EDTH = 1:2 (F1) ; 1:1 (F2) dan 2:1 (F3). Diperoleh Krim tipe M/A, berwarna putih kekuningan, berbau khas, tekstur lembut, homogen, rentang pH 7.3 – 7.5, viskositas 190.000 – 205.000 cPs, diameter daya sebar 5.9 – 6.3 cm, dan nilai aktivitas antioksidan tertinggi diperoleh dari F1 sebesar 25.62 ppm. Ketiga formula stabil pada suhu 40 °C selama 4 minggu penyimpanan, dan hasil uji iritasi menunjukkan F2 memberikan respon iritasi sangat ringan.

UJI AKTIVITAS TABIR SURYA PADA EKSTRAK HERBA SURUHAN (Peperomia pellucida [L.] Kunth) DAN OKTIL METOKSISINAMAT Pratiwi, Inda; Djamil, Ratna; Noor, Siti Umrah
JFL : Jurnal Farmasi Lampung Vol. 13 No. 2 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i2.1844

Herba suruhan (Peperomia pellucida [L.] Kunth) is a plant that contains flavonoids, functioning as a sunscreen. Octyl methoxycinnamate (OMC) is a synthetic compound used in cosmetic products as a sunscreen ingredient. The purpose of this study was to determine the sunscreen activity by determining the SPF value of the extract of herba suruhan (Peperomia pellucida [L.] Kunth) with octyl methoxycinnamate singly. Herba suruhan was extracted by UAE method and then calculated the SPF value of herba suruhan extract with concentrations of 0.06%, 0.07%, 0.08%, 0.09% and 0.1% and the SPF value of octyl methoxycinnamate with concentrations of 1%, 2.5%, 5% and 7.5%. The results of SPF values of Chinese betel herb extract with concentrations of 0.06%, 0.07%, 0.08%, 0.09% and 0.1% were 22, 24, 30, 33 and 39 respectively. The SPF values of octyl methoxycinnamate with concentrations of 1%, 2.5%, 5% and 7.5% were 39, 39, 40 and 40 respectively. The highest SPF value of betel herb extract at a concentration of 0.1% is 39 and octyl methoxycinnamate at a concentration of 5% and 7.5% is 40. Keywords: Peperomia pellucida [L.] Kunth, Octyl methoxycinnamate, sunscreen

Formulation and test of mosquito repellent lotion from the extract of kecombrang (Etlingera elatior (Jack)) and beluntas (Pluchea indica) leaves extract Taurhesia, Shelly; Endah, Endah; Basuki, Witono; Djamil, Ratna
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1521

Dengue fever is an infectious disease which is transmitted by Aedes aegypti mosquitoes and commonly occurs in Indonesia. The use of natural ingredients for mosquito repellent is becoming a trend. Kecombrang (Etlingera elatior (Jack)) is known as a medicinal plant which contains alkaloids, saponins, tannins, phenolics, flavonoids, triterpenoids, steroids, and glycosides. Beluntas (Pluchea indica) contains tannins, alkaloids, flavonoids, phenols, saponins and essential oils. This study aims to develop mosquito repellent lotion using combined leaf extracts of E. elatior and P. indica at different ratios (1:1; 1:2; 2:1). The materials used in this study were E. elatior and P. indica leaves, Aedes aegypti mosquitoes, 96% ethanol, stearic acid, triethanolamine, white oil, methyl paraben, cetyl alcohol, and distilled water. The repellent activity is tested using a standard method of WHO, comparing control group and treatment group, repeating for four times, then the protection level was calculated. The three formulas of lotion fulfilled both physical and chemical requirements and had a repellent activity of above 80%. The formulae of F3, a lotion containing both E. elatior and P. indica leaf extracts of 2:1, gave the highest protection of 88.1%.

Ethnopharmacological study on traditional medicinal plants of the anak dalam tribe in Bukit Dua Belas, Jambi Province as a treatment for diarrhea and antibacterial test Yolandari, Febby Ola; Djamil, Ratna; Chaidir, Chaidir
Science Midwifery Vol 13 No 2 (2025): June: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i2.1954

The Anak Dalam Tribe or Orang Rimba is one of the tribes that live on the island of Sumatra, precisely located in Jambi Province. The Anak Dalam Tribe utilizes plants as a necessity in their lives, one of the benefits of plants used by the Anak Dalam Tribe community as a cure for a disease. This study aims to examine the potential of plants as a cure for diarrhea in the Anak Dalam Tribe, Bukit Dua Belas. This type of research is descriptive research with qualitative methods and snowball sampling techniques through open-ended interviews with 5 informants as Temenggung or tribal chiefs, and 1 informant who is a shaman using interview guidelines. Based on the results of the interview, 14 types of single plants and 4 types of plants in the form of potions were obtained which were used as diarrhea medicine. The plant organs that are utilized include roots, leaves, sap, mushrooms, tubers. The processing method is boiled, squeezed, burned, grated. While its use is by eating, drinking and, sticking to the part of the body that is sick. In the treatment process in the Anak Dalam Tribe, Bukit Dua Belas still uses spiritual methods by relying on the help of Dewo or supernatural powers. In the bacterial inhibition test, the average clear zone results were wider than the others in the test with 96% ethanol extract with Escherichia coli bacteria, the widest clear zone was found in the Lelisau plant at 14.1 mm, in Staphylococcus aureus bacteria, the widest clear zone was in the Mempalas plant at 10.7 mm so that it was included in the strong category. Testing the diameter of the inhibition power using water extract tested with Escherichia coli bacteria, the widest clear zone was found in the Lelisau leaves at 12.35 mm, in Staphylococcus aureus bacteria, the widest clear zone was in the Water Apple plant at 10.6 mm so that it was included in the strong category.

Formulasi dan Uji Aktivitas Antioksidan Krim Kombinasi Ekstrak Biji Kopi Hijau (Coffea canephora var Robusta) dan Ekstrak Daun Teh Hijau (Camellia sinensis (L.)) Lamsari, Lamsari; Taurhesia, Shelly; Djamil, Ratna
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 10 No. 2 (2023): October
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v10i2.5082

Kopi robusta mengandung senyawa alkaloid, flavonoid, saponin, tanin, kafein dan fenol, sedangkan daun teh hijau mengandung senyawa katekin. Senyawa fenol pada kopi dan katekin pada daun teh hijau memiliki aktivitas sebagai antioksidan. Penelitian ini bertujuan untuk mengembangkan formulasi krim dari kombinasi ekstrak biji kopi hijau dan daun teh hijau, yang memiliki aktivitas antioksidan. Biji kopi hijau diekstraksi secara maserasi kinetik menggunakan pelarut kombinasi Isopropanol : air (60:40) sedangkan daun teh hijau diekstraksi dengan pelarut Etanol 70%. Setelah diperoleh ekstrak kental, kemudian dilakukan uji mutu ekstrak serta uji aktivitas antioksidan menggunakan metode DPPH. Nilai IC50 ekstrak biji kopi hijau (EBKH) adalah 22.37 ppm, ekstrak daun teh hijau (EDTH) adalah 7.02 ppm, sedangkan kombinasi EBKH : EDTH (1:1) adalah 11.59 ppm. Kemudian dikembangkan formula krim mengandung kombinasi kedua ekstrak dengan variasi perbandingan EBKH : EDTH = 1:2 (F1) ; 1:1 (F2) dan 2:1 (F3). Diperoleh Krim tipe M/A, berwarna putih kekuningan, berbau khas, tekstur lembut, homogen, rentang pH 7.3 – 7.5, viskositas 190.000 – 205.000 cPs, diameter daya sebar 5.9 – 6.3 cm, dan nilai aktivitas antioksidan tertinggi diperoleh dari F1 sebesar 25.62 ppm. Ketiga formula stabil pada suhu 40 °C selama 4 minggu penyimpanan, dan hasil uji iritasi menunjukkan F2 memberikan respon iritasi sangat ringan.

Antioxidant and Antidiabetic Compounds from Ebony Leaf Extract (Diospyros celebica Bakh.) and Their Correlation with Total Phenolic and Flavonoid Compounds in Various Solvent Extraction Apriandini, Lisya; Hanafi, Muhammad; Djamil, Ratna; Desmiaty, Yesi; Narrij Lotulung, Puspa Dewi; Artanti, Nina
Journal of Natural Product for Degenerative Diseases Vol. 1 No. 1 (2023): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v1i1.5454

Ebony (Diospyros celebica. Bakh) is a native plant of Indonesia that is used as a traditional medicine for diabetes mellitus. Previous studies state that ethanol extract from ebony leaves significantly reduced blood glucose levels of diabetic rats induced by alloxan. This ability is thought to be caused by secondary metabolites which is phenolic and flavonoid compound. However, research related to structure compounds in extract and composition of solvent variations in the extraction process to get the most optimal activity and also their correlation with total phenolic and flavonoid compounds has not been carried out. This study aimed to evaluate the composition of the optimum solvent in the extraction process and also to know the structure compounds contained in the extract. In the present study, we extracted the ebony leaves with three solvents of different polarity (ethanol-water), i.e. ethanol 50% (EtOH), EtOH 70%, and EtOH 96%. Quantitative estimation of total phenolic and flavonoid contents. These extracts were future evaluated for their activity and the content of compounds in the extract was identified using LCMS/MS. The results showed that phenolic compounds that have been identified in ebony leaf extract are methyl gallate and (-)-Epiafzelechin 3-gallate and we found there were significant differences in all test parameters between the three extracts which is EtOH 96% extract gave the best.

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