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All Journal Jurnal Insan Farmasi Indonesia Jurnal AFAMEDIS Jurnal Rumpun Ilmu Kesehatan Indonesian Journal of Pharmacy and Natural Product Jurnal Riset Ilmu Kesehatan Umum dan Farmasi
Cikra Ikhda Nur Hamidah Safitri
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Physics Public Health

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UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN SINTRONG (Crassocephalum crepidioides Benth. S. Moore) PADA Salmonella typhi Panji Ratih Suci; Cikra Ikhda Nur Hamidah Safitri; Nisa’ul Choiroh
AFAMEDIS Vol. 1 No. 2 (2020): Jurnal Farmasi Indonesia Afamedis
Publisher : Akademi Farmasi Mitra Sehat Mandiri Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (211.044 KB)

Abstract

Tumbuhan sintrong (Crassocephalum crepidioides) merupakan tumbuhan gulma yang tersebar di wilayah tropis Asia, termasuk Indonesia. Selain dimanfaatkan sebagai sayuran, sintrong juga dapat digunakan sebagai bahan obat tradisional. Senyawa yang terdapat dalam tumbuhan ini yaitu flavonoid, polifenol, saponin dan tanin. Penelitian ini bertujuan mengetahui adanya aktivitas antibakteri ekstrak daun sintrong (Crassocephalum crepidioides) pada Salmonella typhi. Desain penelitian ini adalah penelitian eksperimental. Pengujian aktivitas antibakteri menggunakan metode difusi cakram. Ekstrak daun sintrong diperoleh dari proses maserasi dengan etanol 70% dan dilakukan skrining fitokimia. Hasil penelitian menunjukkan ekstrak etanol daun sintrong positif mengandung senyawa polifenol, flavonoid, saponin dan tanin. Hasil uji KLT juga menunjukkan bahwa ekstrak daun sintrong positif mengandung flavonoid dengan adanya bercak kuning kehijauan setelah disemprot dengan larutan AlCl3, dengan nilai Rf 0,38 ; 0,82 ;dan 0,92. Adapun diameter daya hambat menunjukkan hasil pada konsentrasi 10% dengam rata-rata ± 9,82, pada konsentrasi 30% dengan rata-rata ± 10,82 serta kontrol positif dengan rata-rata ± 8,87. Sedangkan untuk analisa data menggunakan one way Anova diperoleh hasil bahwa probabilitas signifikan sebesar 0.005 < 0,05, maka dapat disimpulkan bahwa ekstrak daun sintrong (Crassocephalum crepidioides) dapat menghambat pertumbuhan bakteri Salmonella typhi. Dengan hasil tersebut diketahui bahwa ekstrak daun sintrong konsentrasi 30% yang paling berpengaruh dalam menghambat pertumbuhan Salmonella typhi.
Analisis Waktu Tunggu Pelayanan Resep Pasien BPJS Rawat Jalan di RSUD Bangil Cikra Ikhda Nur Hamidah Safitri; M. Rizky Arif; Andri Priyoherianto; Lisa Rahmalia Hildiana; Hartono Hartono
Jurnal Rumpun Ilmu Kesehatan Vol. 4 No. 1 (2024): Maret: Jurnal Rumpun Ilmu Kesehatan
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jrik.v4i1.3610

Abstract

Pharmaceutical Services at the Hospital is an integral part of the Hospital's health care system that is patient-oriented, providing Pharmaceutical Preparations Medical Devices, and Medical Materials that are quality and affordable for all levels of society including clinical pharmacy services (Anonymous, 2016) Besed on the Decree of the Minister of Health of the Republic of Indonesia No 179 Menkes/SK/11/2008, the SPM indicator of hospital pharmacy services includes the waiting time for drug services to be a maximum of 30 minutes while the maximum concoction drug is 60 minutes, the absence of medication errors, stalaction customers at least 80% and prescription writing all must refer to the Hospital formulary This study aims to find out the Waiting Time (Respond Time) of Prescription Services for Finished Medicines and drugs mixed with BPJS patients Outpatient in Bangil Hospital. This research is a non-experimental research with descriptive approach, namely the type of research approach to obtain an overview of the state of a group of data based on observations the real thing is, data collection is done in the Outpatient Pharmacy Service at Hangil Hospital, and is carried out for three months. The total mumber of prescription samples erered in the pharmacy installation for three months a 12.587 prescriptions with details of 10,770 prescriptions of JKN BPJS 85.27% 1,808 peral recipes 14 66% and 9 other insurance recipes 0.07% Among the recipe for JKN BPIS obtained during the study were 90.23% of non-concoction recipes and 9.77% of recipe recipes. The results of the study were obtaining results, the number of prescriptions from patients was 85.27% more than prescriptions from general patients 14 66% and other insurance 0.07%. The average waiting time for non-concoction recipe services in 25 minutes, and concoctions are 62 minutes
Uji Aktivitas Sediaan Sampo Antiketombe Ekstrak Kulit Buah Naga (Hylocereus Polyrhizus) terhadap Pertumbuhan Jamur Candida Albicans Secara in Vitro Zakiyatul Hamida; Panji Ratih Suci; Erna Fitriany; Cikra Ikhda Nur Hamidah Safitri; Nurfitriyawatie Nurfitriyawatie
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 2 No. 3 (2024): Juli : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v2i3.287

Abstract

Dandruff is one of the problems that cause a lack of confidence. The triggering microorganism is Candida albicans. The innovation in the skin of red dragon fruit has the potential as an antibacterial and antifungal because it contains several active compounds such as alkaloids, terpenoids and flavonoids. This study aims to find out at what concentration the anti-dandruff activity on the growth of Candida albicans fungus in the formulation of dragon fruit peel extract shampoo preparation (Hylocereus polyrhizus). This research method is an experimental research using the disc paper diffusion method which consists of making dragon fruit peel extract with the maceration method using 96% ethanol solvent. The extract is formulated in shampoo with concentrations of 20.40 and 80%. The results of this study were in the organoleptis test in the form of a viscous liquid, soft sticky texture, brown and menthol flavor. pH test 6.13, 6.71, 6.39, 5.49. Test the height of the foam 5.8cm, 6.0cm, 6.5cm, 10.3cm. Viscosity test 500 Cp, 612 Cp, 635 Cp, 624 Cp. Homogeneity test is homogeneous. Anti-dandruff shampoo activity test of kontro (+), control (-), concentration of 20%, 40%, 80% with an average of 21.95 mm, 0.00 mm, 22.9 mm, 26.07 mm, 28.52 mm. The conclusion of this study is that the formulation of dragon fruit peel extract shampoo (Hylocereus polyrhizus) has provided an inhibitory effect on the growth of Candida albicans fungus with the strongest inhibitory concentration produced in formulation III with a concentration of 80% of 28.52 mm.
Pengaruh Kombinasi Ekstrak Biji Kemangi (Ocimum basilicum L.) dan Bunga Rosella (Hibicus Sabdarifa L.) Sebagai Anti Hiperglikemia Secara IN VIVO: The Effect Of Basil Seed Extract Combination (Ocimum basilicum L) and rosella Flower (Hibicus Sabdarifa L.) As Anti Hyperglycemia IN VIVO Cikra Ikhda Nur Hamidah Safitri; Anastasya Putri Wahyuni
Indonesian Journal of Pharmacy and Natural Product Vol. 8 No. 01 (2025): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ijpnp.v8i01.3774

Abstract

Rosella plant is a plant that has biological activities such as antihypertensive, antioxidant, and hypoglycemic activity. Basil seeds are traditionally also often used as an aroma enhancer in food in the long term and have a significant effect on blood sugar levels. The purpose of this study was to determine the effectiveness of combination therapy of the two drugs working synergistically which will have a potentiation effect. This study was experimental. The doses of basil seed extract, rosella flower extract, Glibenclamide and their combinations have different doses. Basil seed extract (100mg/kg), rosella flower extract (100mg/kg), Glibenclamide (0.5mg/kg) and their combinations (6 groups, n=5). Antihyperglycemic activity was tested using alloxan-induced male rats by estimating fasting blood glucose levels and observing changes in fasting blood glucose levels on days 1, 3, 7, 14, and 21 after treatment. On the 21st day, blood samples were collected and tested. Combination therapy did not show synergistic effects, but blood glucose levels decreased significantly (P <0.001) since the first day and returned to normal on the 21st day after treatment. A single dose of basil seeds and rosella flowers induced by alloxan has antihyperglycemic potential, The potential of herbal antihyperglycemic formulation is comparable to glibenclamide, as indicated by a decrease in glucose levels.   ABSTRAK Tanaman rosella adalah tanaman yang memiliki aktivitas biologi seperti antihipertensi, antioksidan, dan aktivitas hipoglikemik. Biji kemangi Secara tradisional juga sering digunakan sebagai penambah aroma pada makanan dalam jangka panjang memiliki pengaruh yang signifikan terhadap kadar gula darah.  Tujuan penelitian ini untuk menentukan efektivitas terapi kombinasi kedua obat tersebut bekerja secara sinergis yang akan berefek potensiasi. Penelitian ini merupakan eksperimental. Dosis ekstrak biji kemangi, ekstrak bunga rosella, Glibengclamide dan Kombinasinya mempunyai dosis yang berbeda. Ekstrak Biji kemangi (100mg/kg), Ekstrak Bunga rosella (100mg/kg), Glibenclamide (0,5mg/kg) dan Kombinasinya (6 kelompok,n=5). Aktivitas antihiperglikemia diuji menggunakan tikus jantan yang diinduksi aloksan dengan memperkirakan kadar glukosa darah puasa dan mengamati perubahan kadar glukosa darah puasa pada hari ke-1, 3, 7, 14, dan 21 setelah perlakuan. Pada hari ke-21 sampel darah dikumpulkan dan di uji. Terapi kombinasi tidak menunjukkan efek sinergis, namun kadar glukosa darah mengalami penurunan yang sangat signifikan (P <0,001) sejak hari pertama dan kembali normal pada hari ke-21 setelah perlakuan. Dosis tunggal pada biji kemangi dan bunga rosella yang diinduksi aloksan memiliki potensi antihiperglikemia, Potensi formulasi Antihiperglikemia herbal sebanding dengan glibenklamid, yang ditunjukkan dengan penurunan kadar glukosa.
KOMBINASI EKSTRAK SECANG (CESALPINIA SAPPAN L.) DAN METFORMIN SEBAGAI ANTI HIPERGLIKEMIA SECARA IN VIVO Cikra Ikhda Nur Hamidah Safitri; Putri Ade Muhaimatus Solikhah
Jurnal Insan Farmasi Indonesia Vol 8 No 1 (2025): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v8i1.2506

Abstract

Secang wood (Caesalpinia sappan L.) is considered one of the sources of modern medicine that may have effective hypoglycemic effects, or lowering blood sugar. This wood is rich in various phytochemicals. The aim of this study is to observe how the combination of secang bark extract and metformin acts as an antihyperglycemic in male rats. This research is an experimental study. The doses used include Secang wood extract of 285.71 mg/kg and 666.66 mg/kg, Metformin 300 mg/kg, and a combination of both in a ratio of 1:1. The test animals were divided into seven groups (each consisting of five individuals). Diabetes induction was performed using alloxan. Blood glucose levels were measured at baseline, on days 1, 3, 7, 14, and 21 after treatment. Data were analyzed using ANOVA. The results showed that the combination therapy provided a synergistic effect, marked by a highly significant decrease in blood glucose levels (p < 0.01) starting from day one, and the glucose levels returned to normal on day 21 after treatment. The administration of Secang wood extract alone has antihyperglycemic potential, and when combined with metformin, it produces a significant hypoglycemic effect.
Co-Authors Anastasya Putri Wahyuni Andri Priyoherianto ERNA FITRIANY, ERNA Hartono Hartono Lisa Rahmalia Hildiana M. Rizky Arif Nisa’ul Choiroh Nurfitriyawatie Nurfitriyawatie Panji Ratih Suci Putri Ade Muhaimatus Solikhah Zakiyatul Hamida