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All Journal International Conference on Health Science, Green Economics, Educational Review and Technology (IHERT)
Dian Permata Nasution
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Computer Science & IT Economics, Econometrics & Finance Education Health Professions

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ANTI-INFLAMMATORY EFFECT OF LEAF ETHANOL EXTRACT OF CAT'S KUMIZE (Orthosiphon stamineus Benth) IN MALE WHITE RATS OF WISTAR STRAINS Meyana Marbun; Dian Permata Nasution; Beta Hanindiya; Mustaruddin; Yulia Delfahedah; Arsiaty
International Conference on Health Science, Green Economics, Educational Review and Technology Vol. 3 (2021): International Conference on Health Science, Green Economics, Educational Review and T
Publisher : Universitas Efarina

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54443/ihert.v3i.244

Abstract

The cat's whiskers plant is empirically used by the community for the treatment of gout and rheumatism. This research was conducted with the aim of knowing the anti-inflammatory power of cat's kumis (Orthosihon stamineus Benth) leaf extract. This study was a quasi-experimental study with a one-way completely randomized design. Kumis Kucing leaf extract was extracted using 70% ethanol. A total of 25 male wistar rats aged 2-3 months, weighing 150-200g were divided into 5 groups. Each group was treated orally with distilled water (negative control), diclofenac sodium 2.25 mg/kg BW (positive control). Kumis leaf ethanol extract tested at doses of 123, 245 and 490 mg/kgBB. Treatment 1 hour before the feet of rats were inflamed with 1% sublantar carrageenin. Measurements of the rat's foot volume were carried out every 0.5 hours for 6.5 hours. The obtained average edema volume curve is used to calculate AUC (Area Under The Curve) and the obtained AUC is used to calculate DAI (Anti-Inflammatory Power). The AUC and DAI data were tested statistically with one way Anava and followed by LSD with a 95% confidence level. The results showed that the ethanol extract of Kumis Kucing leaves had an anti-inflammatory effect on male white rats of the Wistar strain. Kumis Kucing ethanol extract at doses of 123, 245 and 490 mg/kg BW yielded 33.11%; 52.64% and 64.12% respectively. The results showed that the ethanol extract of Kumis Kucing leaves had an anti-inflammatory effect on male white rats of the Wistar strain. Kumis Kucing ethanol extract at doses of 123, 245 and 490 mg/kg BW yielded percent anti-inflammatory properties of 33.11%; 52.64% and 64.12%, respectively. The results showed that the ethanol extract of Kumis Kucing leaves had an anti-inflammatory effect on male white rats of the Wistar strain. Kumis Kucing ethanol extract at doses of 123, 245 and 490 mg/kg BW yielded percent anti-inflammatory properties of 33.11%; 52.64% and 64.12%, respectively.
RATIONALITY OF THE USE OF NSAIDS IN rheumatic OSTEOARTHRITIS PATIENTS AT THE PUSKESMAS SINGOSARI, PEMATANGSIANTA CITY, JANUARY FEBRUARY 2019 PERIOD I Ngurah Gede Verar Fujastawan; Mustaruddin; Beta Hanindiya; Dian Permata Nasution; Ismi Noer Fadilah; Hendri Kurniawan; Marthalea Erbin Nahak; Bernido Raflo Purba
International Conference on Health Science, Green Economics, Educational Review and Technology Vol. 4 (2022): International Conference on Health Science, Green Economics, Educational Review and T
Publisher : Universitas Efarina

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54443/ihert.v4i.245

Abstract

Osteoarthritis (OA) is the most common form of arthritis found in the community, is chronic in nature, has a major impact on public health issues. a total of 213 arthritis patients, only 30 patients who met the inclusion criteria were due to incomplete medical record data or even loss of medical record data which caused the patient's medical record data to be incomplete. As for the aspect of rationality in terms of 6 accuracy (right diagnosis, right indication, right drug, right dose, right route of administration, right patient) then the results of the analysis show that accuracy is 100% right, while for the exact parameters of the drug is still worth 53%. So it can be concluded that treatment for osteoarthritis patients when viewed from the right diagnosis, right indication, right dose, right patient, right drug, right method of administration at the Singosari Health Center cannot be fully rational.
Co-Authors Arsiaty Bernido Raflo Purba Beta Hanindiya Hendri Kurniawan I Ngurah Gede Verar Fujastawan Ismi Noer Fadilah Marthalea Erbin Nahak Meyana Marbun Mustaruddin Yulia Delfahedah