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All Journal THE JOURNAL OF MUHAMMADIYAH MEDICAL LABORATORY TECHNOLOGIST Sanus Medical Journal
Irena Ujianti
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Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Gambaran Hematologi pada Defisiensi Vitamin B12 Irena Ujianti
Sanus Medical Journal Vol. 2 No. 2 (2021): Vol. 2 No. 2 (2021): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v2i2.7327

Abstract

Background and Aims. Anemia is a condition when the number of red blood cells or hemoglobin is lower than the normal number. The main cause of anemia is a lack of factors for the formation and maturation of red blood cells. Vitamin B12 plays a role in the synthesis and maturation of red blood cells, a lack of this vitamin will cause the formation and maturation of red blood cells to be disrupted. Method. This was an experimental animal study with twelve rats with frederer's family. The rat was fed a Vitamin B12 Deficient Diet for 16 weeks as the treatment group and standard diet as the control group. Vitamin B12 in the liver was analyzed in rats for 16 weeks. Hemoglobin and MCV were analyzed in plasma for 16 weeks. Results are expressed as means of control, and test animals were established by ANOVA using SPSS 20.0 software Results. In the present study, we found that liver vitamin B12 level was decreased in treatments groups compares to the positive control group at sixteen weeks (p<0.01). Hemoglobin was decreased in the treatment group compare positive control group at sixteen weeks (p<0.001). Mean Corpuscular Volume (MCV) was increased in the treatment group's compare positive control group at sixteen weeks (p<0.01) Conclusions. Our findings demonstrate that vitamin B12 deficiency decreased hemoglobin and increased MCV.
Specific Primer Design to Detect Connexin-36 Gene in Rattus Norvegicus Brain Sri Suciati Ningsih; Alfina Septiasari; Endin Nokik Stujanna; Rizkyana Avissa; Irena Ujianti; Shinta Dewi Permatasari; Wawang S. Sukarya
THE JOURNAL OF MUHAMMADIYAH MEDICAL LABORATORY TECHNOLOGIST Vol 7 No 1 (2024): The Journal of Muhammadiyah Medical Laboratory Technologist
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jmlt.v7i1.17985

Abstract

Connexin-36 (Cx36) merupakan salah satu protein kanal antar sel. Protein ini paling banyak ditemukan pada otak. Gen Cx36 mengekspresikan protein penghubung Cx36 yang membentuk sinaps listrik. Penelitian ini bertujuan untuk memperoleh desain primer terbaik untuk menganalisis ekspresi Cx36 pada otak tikus dengan metode Quantitative Real Time PCR (qRT-PCR). Jenis penelitian ini adalah penelitian true experimental menggunakan mRNA dari 4 otak tikus. Analisis in silico menggunakan tools Primer 3 dan OlygoAnalizerTM by IDTdengan menggunakan database gen pada NCBI. Tiga primer dengan kriteria yang paling optimum kemudian dievaluasi dengan metode qRT-PCR. Berdasarkan hasil penelitian ketiganya mampu mengamplifikasi gen Cx36 dengan menggunakan qRT-PCR. Hasil primer terbaik menunjukkan melt curve tunggal pada primer no.5 gen Cx36 pada kisaran Tm 80-81oC. Hasil perbandingan uji in silico primer Cx36 yang sudah pernah dipublikasi sebelumnya menunjukkan bahwa primer no. 5 juga memiliki nilai optimal pada setiap kriteria. Maka hasil desain primer yang memiliki spesifisitas dan efektifitas yang optimum untuk mengamplifikasi gen Cx36 pada otak tikus Rattus norvegicus ialah primer no.5 (F: 5’-ATTTCCCGCTTCTACATCATCCAAG-3’ dan R: 5’-CACAGCAAACATGAACACCAGAAAG-3’).
Difficulties Differentiating Between Basal Cell Carcinoma and Trichoepithelioma: A Case Report Nurusshofa, Zahra; irena ujianti
Sanus Medical Journal Vol. 2 No. 2 (2021)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v2i2.7371

Abstract

Background. Basal cell carcinoma (BCC) is the most common type of malignant skin tumor with basal cell differentiation. Trichoepithelioma (TE), however, is a rare benign skin tumor with follicular differentiation. Both types of tumor have commonalities in terms of clinical and histopathological features. Some cases, in fact, require ancillary studies to distinguish between the two. Confusing the two tumors may result in different future outcomes for the patient, due to their vastly different prognoses and treatments. This case report outlines two different cases, and discusses how to distinguish between the two types of tumor without the use of an ancillary study.Method. We examined the cases of one patient with basal cell carcinoma and one patient with trichoepithelioma, comparing their clinical manifestations and characteristic histological features.Results. Trichoepithelioma and BCC share several overlapping histopathological features. Trichoepithelioma and BCC share several overlapping histopathological features. The TE in this case report also exhibited a nodular pattern, connection to the epidermis, stromal cleft, and prominent nuclear palisading, which are more commonly found in BCC. However, scanty mitotic activity, the presence of non-atypia cells, and symmetry of the lesion, are favor TE.Conclusion. Differentiation between BCC and TE is only possible using cytomorphological assessment with a high-power field of view.
Examining Oxygen Saturation and Peak Volume Correlation in Respiratory Disorders: A Study at PCM/PCA Ciledug Fitriana, Rizni; Irena Ujianti; Teguh Haryo Sasongko; Yashiro, Takashi
Sanus Medical Journal Vol. 5 No. 2 (2023)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v5i2.14488

Abstract

This cross-sectional study sought to determine the correlation between oxygen saturation and peak flow meter readings, taking into account hemoglobin levels. Participants aged 55 years and over were examined using direct measurement methods, with hemoglobin measured via the strip test method, and oxygen saturation and peak flow meter values assessed using a pulse oximeter and peak flow meter, respectively. Analysis of the collected data from 12 subjects, averaged 63 years old, revealed a significant correlation between oxygen saturation (average 96.6%) and peak flow volume (average 223.3 mL/mnt) (r=0.727, p=0.007). The findings suggest that this relationship is more potent in individuals with respiratory disorders or under certain environmental risk factors. Nonetheless, in healthier contexts, the correlation may be weaker or absent, emphasizing the need for further research to enhance the management of respiratory and lung disorders
Co-Authors Alfina Septiasari Endin Nokik Stujanna Fitriana, Rizni Nurusshofa, Zahra Rizkyana Avissa Shinta Dewi Permata Sari Sri Suciati Ningsih Teguh Haryo Sasongko Wawang S. Sukarya Yashiro, Takashi