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All Journal Jurnal Kesehatan Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Human Care Journal Ophthalmologica Indonesiana
Weni Helvinda
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Pengaruh Bevacizumab Intravitreal terhadap Best Corrected Visual Acuity dan Central Macular Thickness pada Diabetic Macular Edema Arini Ghaisa Atsari; Weni Helvinda
Jurnal Kesehatan Andalas Vol 8, No 4 (2019): Online December 2019
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v8i4.1094

Abstract

Diabetic Macular Edema (DME) adalah penyebab utama kebutaan pada populasi diabetes. Salah satu patogenesis pada DME adalah karena peningkatan ekspresi VEGF. Bevacizumab adalah anti-VEGF yang dapat meningkatkan Best Corrected Visual Acuity (BCVA) dan mengurangi Central Macular Thickness (CMT) pada pasien DME. Tujuan: Mengetahui persentase jenis kelamin, usia, durasi DM tipe II, BCVA dan CMT sebelum dan setelah injeksi pada bulan pertama dan bulan ketiga pada pasien DME serta menganalisis pengaruh intravitreal bevacizumab anti-VEGF terhadap BCVA dan CMT pada DME di Rumah Sakit M Djamil Padang. Metode: Penelitian ini adalah studi retrospektif analitik berdasarkan rekam medis dari 16 pasien DME yang telah injeksi bevacizumab intravitreal pada tahun 2017. Data dianalisis secara statistik menggunakan uji one way Anova dengan p < 0,05 dianggap signifikan. Hasil: Pasien terdiri dari 11 wanita (68,8%) dan 5 pria (31,2%). Jumlah usia pasien terbanyak antara 51-55 tahun (43,8%) dan durasi terlama yang diketahui DM tipe II adalah 5-10 tahun (50,0%). Rata-rata BCVA (logMAR) sebelum injeksi intravitreal bevacizumab adalah 0,95, bulan pertama setelah injeksi adalah 0,68, dan bulan ketiga setelah injeksi adalah 0,55. CMT rata-rata sebelum injeksi bevacizumab intravitreal adalah 427,62, bulan pertama setelah injeksi 359,59, dan bulan ketiga setelah injeksi 318,12. Simpulan: Terdapat pengaruh bevacizumab anti-VEGF intravitreal terhadap BCVA dan CMT di DME di Rumah Sakit M Djamil Padang.
INJEKSI INTRAVITREAL RANIBIZUMAB PADA POLYPOIDAL CHOROIDAL VASCULOPATHY (PCV) Haris Budiman; Weni Helvinda
HUMAN CARE JOURNAL Vol 5, No 4 (2020): Human Care Journal
Publisher : Universitas Fort De Kock

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32883/hcj.v5i4.860

Abstract

Introduction: Polypoidal choroidal vasculopathy (PCV) is a peculiar form of choroidal neovascularization characterized by protrusion of the aneurysm at the end of the choroidal blood vessels. The aim of this study is to report a case of   PCV in a young woman who treated with intravitreal ranibizumab injection. Method: The patient undergoes general ophthalmic examinations, amsler grid, funduscopic photography and OCT analysis. The repeated examination performed after intravitreal injection of ranibizumab to assess the effect of therapy. Result:  Two weeks after intravitreal ranibizumab injection, the visual acuity was improved and on OCT examination revealed decreasing in macular thickness. Conclusion: Intravitreal ranibizumab injection can give good result, but in this case the effectiveness hasn’t so evident because of the administration only once and follow-up only in two weeks.
PERBANDINGAN RETINAL GANGLION CELL THICKNESS DAN PERIMETRI PASIEN DIABETES MELITUS TIPE 2 sherly muchlis muchlis; Ardizal Rahman; Weni Helvinda
HUMAN CARE JOURNAL Vol 5, No 3 (2020): Human Care Journal
Publisher : Universitas Fort De Kock

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32883/hcj.v5i3.788

Abstract

Diabetic retinopathy (RD) is a microvascular complication that often occurs in diabetes mellitus (DM). Retinal ganglion cells (RGC) are reduced in the early stages of DM, even before microvascular abnormalities are seen on the retina. Methods: Sample of 35 eyes of non RD RD type 2 patients and 35 mild non proliferative diabetic retinopathy (NPDR) eyes After examination of ophthalmological status, perimetry and optical coherence tomography (OCT) were examined. Results: The mean MD on non-RD type 2 DM -2.74 ± 3.5 mild NPDR -5.61 ± 4.5 with p value 0.414. The average non-RD type 2 PSD DM was -3.35 ± 3.3, mild NPDR was 4.16 ± 1.4 with a p value of 0.206. The mean RGC thickness of patients with non-RD type 2 DM was 83.8 ± 7.4 µm, mild NPDR 82.7 ± 8.1 μm. There was a decrease in the value of RGC thickness, MD and PSD in patients with type 2 DM, but it was not statistically significant . Conclusion: No significant difference was found in RGC thickness in DM patients between non-RD and mild NPDR. No significant difference was found between MD and PSD in DM patients between non-RD and mild NPDR. No significant relationship was found between RGC thickness and perimetry in DM patients between non-RD and mild NPDR. 
TOKSOPLASMOSIS OKULAR dessy ariyeni; Weni Helvinda
HUMAN CARE JOURNAL Vol 5, No 2 (2020): Human Care Journal Special Edition
Publisher : Universitas Fort De Kock

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32883/hcj.v5i2.783

Abstract

Tujuan: Toksoplasmosis merupakan penyakit yang disebabkan oleh Toksoplasma gondii yang merupakan protozoa obligat intraselular. Parasit ini mempunyai 3 bentuk morfologi yang berbeda, yaitu: tachizoites, bradizoites dan ookista. Transmisi parasit ke manusia dapat terjadi dengan cara termakan makanan yang mengandung ookista atau kista jaringan yang terdapat di dalam daging yang dimasak tidak sempurna. Metode: Pada laporan kasus ini dilaporkan kasus dengan diagnosis toksoplasmosis okular pada 5 pasien yang datang ke RS Dr. M. Djamil Padang antara bulan Februari – Mei 2015. Lima  pasien datang dengan keluhan penglihatan kabur dengan onset yang berbeda-beda. Hasil: Pada pemeriksaan oftalmologi didapatkan penurunan visus unilateral dan terdapatnya lesi di polus posterior dengan pinggir hiperpigmentasi pada pemeriksaan funduskopi. Semua pasien diberikan terapi trimethoprim / sulfamethoxazole  selama 6 minggu. Kesimpulan: Perbaikan visus pada pasien toksoplasmosis okular terjadi setelah pemberian terapi selama 6 minggu dengan terapi trimethoprim / sulfamethoxazole walaupun tidak terlalu signifikan karena terdapatnya lesi didaerah makula.
Recurrence in Toxoplasma Chorioretinitis: A Case Report: Poster Presentation - Case Report - Resident Pratistha Satyanegara; Weni Helvinda
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/krvazm74

Abstract

Introduction : Toxoplasma is the most common cause of chorioretinitis and recurrency of toxoplasma chorioretinitis often occur. Recurrences risk factors are patients above 40 years, patients with de novo toxoplasmosis lesions or with less than one year after the first episode, macular area involvement, lesions greater than one disc diameter, congenital toxoplasmosis, and bilateral compromise. Case Illustration : Female, twenty years old, complained blurred vision on the RE for two years. The patient had a history of cat contact and no systemic manifestation. Anterior segment examination in both eyes is normal with right eye visual acuity 1/60 and left eye visual acuity VA 6/6. Posterior segment examination on the left eye showed normal limit while the right eye showed hyperpigmentation in inferotemporal optic disc and nasal macula. Retina showed hard exudate. Macula showed yellow- white exudate with subretinal bleeding and macular star appearance. Foveal reflex under normal limit. Toxoplasma serology was IgG (+) and IgM (-). The patient has been treated with cotrimoxazole 2x960mg and methylprednisolone 1x32mg. Discussion : Visual acuity is severely damaged in recurrence toxoplasma chorioretinitis. There are several factors that affect the recurrences of toxoplasma chorioretinitis. In this patient, the risk factors found are de novo lesion, lesions greater than 1 disc diameter, and macular involvement. Cotrimoxazole can reduce recurrence in toxoplasma chorioretinitis but still recurrency can occur. Conclusion : Recurrences in toxoplasma chorioretinitis affect visual acuity, and even with adequate therapy, recurrence is possible.
Prevalence and Risk Factors of Diabetic Retinopathy in a Tertiary Hospital in Padang, Indonesia Novian Adi Saputra; Weni Helvinda; Khalilul Rahman
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 1 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i1.1173

Abstract

Background: Diabetic retinopathy (DR) is a prevalent microvascular complication of diabetes, leading to vision impairment and blindness. This study aimed to determine the prevalence and risk factors associated with DR among patients attending a tertiary care center in Padang, Indonesia. Methods: A cross-sectional study was conducted at the eye polyclinic of Dr. M. Djamil General Hospital, Padang, Indonesia, from October 2020 to March 2021. Patients diagnosed with diabetes who underwent a comprehensive ophthalmological examination were included. Data collected included demographics, duration of diabetes, cholesterol levels, and DR status (classified as non-proliferative diabetic retinopathy (NPDR) or proliferative diabetic retinopathy (PDR)). Results: A total of 200 patients with diabetes were included. The prevalence of DR was 55%, with 40% having NPDR and 15% having PDR. Multivariate analysis revealed that longer diabetes duration (odds ratio [OR] 1.8, 95% confidence interval [CI] 1.2-2.7, p=0.004), higher cholesterol levels (OR 2.5, 95% CI 1.5-4.1, p=0.001), and older age (OR 1.1, 95% CI 1.0-1.2, p=0.03) were independently associated with the presence of DR. Conclusion: DR is highly prevalent among diabetic patients in tertiary care center Padang, Indonesia. Longer diabetes duration, elevated cholesterol, and older age are significant risk factors for DR. Early detection and management of these risk factors are crucial to prevent vision loss in this population.
Co-Authors Anak Agung Gede Sugianthara Ardizal Rahman Arini Ghaisa Atsari dessy ariyeni Khalilul Rahman NOVIAN ADI SAPUTRA Pratistha Satyanegara sherly muchlis muchlis