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All Journal Jurnal Neuroanestesi Indonesia Physical Therapy Journal of Indonesia IIJSE
Soetomo, Cindy Thiovany
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Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Dormant No More: The Neurogical Impact of Herpes Simplex Virus Reactivation Following Traumatic Brain Injury Johansyah, Theodorus Kevin Putra; Soetomo, Cindy Thiovany; Tiffany, Tiffany; Maliawan, Sri
Jurnal Neuroanestesi Indonesia Vol 14, No 1 (2025)
Publisher : https://snacc.org/wp-content/uploads/2019/fall/Intl-news3.html

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24244/jni.v14i1.659

Abstract

Herpes simplex viruses (HSV), including HSV-1 and HSV-2, are neurotropic viruses capable of establishing lifelong latency in sensory ganglia and reactivating under various triggers, including traumatic brain injury (TBI). TBI induces secondary injury cascades such as neuroinflammation, excitotoxicity, and blood-brain barrier disruption, which create a conducive environment for HSV reactivation. The reactivation of HSV after TBI, particularly HSV-1 and HSV-2, can lead to significant neurological consequences, including encephalitis, cognitive decline, and the development of neurodegenerative diseases like Alzheimers disease and Chronic Traumatic Encephalopathy. Current therapeutic approaches focus on antiviral agents like acyclovir and valacyclovir, which manage acute HSV infection but are less effective in preventing long-term neurological damage. Emerging research highlights the potential of anti-inflammatory and neuroprotective strategies to complement antiviral therapies, aiming to reduce the neuronal damage caused by viral reactivation and inflammation. However, gaps remain in understanding the precise mechanisms linking TBI-induced neuroinflammation to HSV reactivation and its long-term impact on neurological health. This review synthesizes the current literature on the pathophysiology of HSV reactivation following TBI, and their contributions to acute and chronic neurological outcomes
The Effect of Organizational Culture, Team Collaboration, and Work Motivation on the Performance of Health Workers in Cahaya Bunda Mother and Child Hospital Soetomo, Cindy Thiovany; Gunawan, Made Favian Budi; Fernaldi, Kelvin; Hasan, Halimah
Indonesian Interdisciplinary Journal of Sharia Economics (IIJSE) Vol 8 No 2 (2025): Sharia Economics
Publisher : Sharia Economics Department Universitas KH. Abdul Chalim, Mojokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31538/iijse.v8i2.6081

Abstract

Cahaya Bunda Mother and Child Hospital in Bali is dedicated to improving healthcare standards for mothers and children, focusing on reducing maternal and infant mortality rates. The performance of healthcare workers is a critical factor in achieving optimal patient outcomes, particularly in specialized hospitals such as mother and child hospitals. However, health worker performance is influenced by various factors, including organizational culture, team collaboration, and work motivation. This study aims to analyze the individual and collective effects of these factors on health worker performance. Using a quantitative approach, data were collected through a structured questionnaire distributed to 34 nurses and midwives. SmartPLS 3.2 software was employed for analysis. The findings reveal that work motivation significantly impacts health worker performance, underscoring its critical role in driving effectiveness and commitment to healthcare services. Conversely, organizational culture and team collaboration showed no statistically significant effects on performance, which may be attributed to sample size limitations and contextual factors within the hospital environment. The study highlights that while a supportive culture and collaborative environment are essential, intrinsic motivation remains a key driver of performance outcomes. This research contributes to understanding how motivation directly influences healthcare workers’ productivity, while organizational culture and team collaboration provide a foundation that indirectly supports performance. Future studies should explore the interplay between these factors to develop targeted strategies for optimizing healthcare delivery in specialized settings like mother and child hospitals.
Clinical efficacy of bone marrow mesenchymal stem cells in chronic spinal cord injury: A single-arm meta-analysis of clinical trials Wardhana, Dewa Putu Wisnu; Soetomo, Cindy Thiovany; Satyarsa, Agung Bagus Sista; Maliawan, Sri; Mahadewa, Tjokorda Gde Bagus
Physical Therapy Journal of Indonesia Vol. 6 No. 2 (2025): Inpress July-December 2025
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v6i2.318

Abstract

Background: Chronic spinal cord injury (SCI) leads to irreversible neurological deficits with limited therapeutic options, making it a major challenge in neuroregenerative medicine. This study aimed to evaluate the clinical efficacy of bone marrow mesenchymal stem cells (BMMSC) therapy in patients with chronic SCI using a single-arm meta-analysis. Methods: This research was conducted using the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, covering studies up to August 2024 in PubMed, CENTRAL, and ScienceDirect. Included trials applied BMMSC therapy in patients ≥1 year post-injury. A random-effects model was employed using R software. Outcomes included changes in the American Spinal Injury Association (ASIA) impairment scale, somatosensory evoked potentials (SSEP), motor evoked potentials (MEP), infralesional voluntary muscle contraction (IVMC), active muscle reinnervation (AMR), and urodynamic parameters. Heterogeneity was assessed with the I² statistic, and study quality was evaluated via ROBINS-I. This study has been registered on PROSPERO with registration number CRD42024577161. Results: Seven studies comprising 133 patients were included. AIS grade improvement was observed in 0.37 (95% CI: 0.24–0.52). Improvements were also seen in SSEP at 0.40 (95% CI: 0.18–0.67), MEP at 0.37 (95% CI: 0.25–0.51), IVMC at 0.47 (95% CI: 0.34–0.60), and AMR at 0.74 (95% CI: 0.39–0.92). Urodynamic outcomes demonstrated increased maximum cystometric capacity [0.48 (95% CI: 0.30–0.67)], improved bladder compliance [0.73 (95% CI: 0.55–0.85)], and reduced detrusor pressure [0.61 (95% CI: 0.43–0.76)]. Conclusion: BMMSC therapy was associated with clinically meaningful neurological and urodynamic improvements in chronic SCI. Standardized administration protocols and randomized controlled trials are necessary to validate efficacy and optimize treatment paradigms.
Co-Authors Agung Bagus S. Satyarsa Dewa Putu Wisnu Wardhana Fernaldi, Kelvin Gunawan, Made Favian Budi Hasan, Halimah Johansyah, Theodorus Kevin Putra Sri Maliawan Tiffany, Tiffany Tjokorda Gde Bagus Mahadewa