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All Journal Jurnal Ilmiah Cendekia Eksakta Jurnal Penyakit Dalam Indonesia Plexus Medical Journal
Agung, Ratih Arianita
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Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Health Professions Mechanical Engineering Medicine & Pharmacology Public Health

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Pain Management in Advanced Hepatocellular Carcinoma:A Case Study Fitrianti, Fita; Shatri, Hamzah; Faisal, Edward; Putranto, Rud; Agung, Ratih Arianita; Nainggolan, Leonard; Kalista, Kemal Fariz; Irawan, Cophiadi
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 1
Publisher : UI Scholars Hub

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Abstract

Hepatocelullar carcinoma (HCC), the most common primary liver malignancy is the fifth most common cancer and the third most frequent cause of cancer related death globally. Pain comprises one the most common symptoms of HCC and may have severely negative effects on patient’s quality life. Furthermore, patients with HCC often presented with a cirrochis,so to control pain in this patient poses a clinical challenge. This case report discuss about a young 26-years-old male patient who presented with a four-month history of right upper quadrant abdominal pain and weight loss. HbsAg positive and serum alpha-fetoprotein level was high. Computed tomography (CT) and liver biopsy confirmed the presence of primary hepatocellular carcinoma.,with lung metastatic from the radiologic x-ray. Patient came with a loss of consciousness due to hypoglicemia. During hospitalization, patient complaint of abdominal pain and was given morphine intermediate release (MIR) to control the pain. By administering measurable and well-controlled opioids, the patient’s suffering can be reduced, thus improving the patient’s quality of life
Hubungan Tingkat Stres dan Kualitas Tidur dengan GERD pada Mahasiswa Kedokteran Universitas Sebelas Maret Ridho, Muhammad Ihsan; Agung, Ratih Arianita; Darmayani, Aritantri
Plexus Medical Journal Vol. 4 No. 2 (2025): April
Publisher : Fakultas Kedokteran, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/plexus.v4i2.798

Abstract

Pendahuluan: Gastroesophageal reflux disease (GERD) adalah penyakit gastrointestinal kronis yang secara signifikan mengurangi kualitas hidup dan pada beberapa pasien menyebabkan komplikasi yang serius. Mahasiswa kedokteran adalah sekelompok mahasiswa dengan tingkat stres yang sangat tinggi, dan kelelahan terkait pekerjaan yang menyebabkan gangguan tidur, termasuk kurang tidur, kualitas tidur yang buruk, dan kantuk di siang hari. Sampai sekarang belum banyak penelitian multivariat yang meneliti hubungan tingkat stress dan kualitas tidur dengan kejadian GERD. Penelitian ini bertujuan untuk mengetahui hubungan antara tingkat stres dan kualitas tidur dengan kejadian GERD pada mahasiswa kedokteran Universitas Sebelas Maret. Metode: Penelitian ini adalah penelitian observasional analitik dengan pendekatan cross sectional. Sampel penelitian berjumlah 90 orang responden yang telah memenuhi kriteria inklusi dan ekslusi. Pengambilan sampel dilakukan dengan teknik total sampling. Data yang diperoleh dianalisis secara bivariat dengan menggunakan uji koefesien kontingensi dan secara multivariat dengan menggunakan uji regresi logistik. Hasil: Hasil penelitian ini menunjukkan hubungan yang signifikan antara tingkat stres (p < 0,001) dan kualitas tidur (p = 0,042) dengan kejadian GERD. Berdasarkan hubungan dengan kejadian GERD (p<0,001). Kesimpulan: Tingkat stres dan kualitas tidur secara parsial dan simultan memiliki hubungan dengan kejadian GERD. Tingkat stres diketahui memiliki hubungan yang lebih bermakna dengan kejadian GERD jika dibandingkan dengan kualitas tidur.
Symptom Burden and the Efficacy of Psychosocial Interventions in Conservatively Managed End-Stage Kidney Disease: A Systematic Review Hidayat, Agung Wahyu; Agung, Ratih Arianita; Putri, Chintia Dyah Ayuning
CENDEKIA EKSAKTA Vol. 11 No. 1 (2026): April Edition – In Progress
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jice.v11i1.15535

Abstract

Background: Conservative kidney management (CKM) is an increasingly adopted alternative to dialysis for patients with end-stage kidney disease (ESKD), emphasizing quality of life. However, the prevalence of physical and psychological symptoms in this population remains under-evaluated.Objective: This systematic review aims to synthesize the prevalence, severity, and clinical impact of pain and psychological distress (depression, anxiety, and fatigue) in conservatively managed ESKD patients and to evaluate the efficacy of psychosocial interventions.Methods: Following PRISMA guidelines, a comprehensive search of PubMed, Embase, and Scopus was conducted for studies published between January 2015 and July 2025. Methodological quality was appraised using the Newcastle-Ottawa Scale (NOS). Eligible studies included adults ( 18 years) with ESKD managed without dialysis.Results: Seventeen studies () were included. Symptom prevalence was high: pain (38–72%), depression (25–55%), anxiety (19–48%), and fatigue (40–75%). Up to 60% of patients reported moderate-to-severe bone pain, and 70% experienced significant functional impairment due to fatigue. All symptom domains significantly correlated with diminished quality of life (KDQOL scores, ). Psychosocial interventions—including hope therapy, mindfulness-based resilience, and integrated palliative care—consistently demonstrated significant improvements in psychological outcomes ( to ) and emotional well-being.Conclusion: Pain and psychological distress represent a substantial burden in the CKM population. Integrating routine multidisciplinary assessment and evidence-based psychosocial support is essential to optimize patient-centered outcomes in conservative kidney care. Keywords: end-stage kidney disease, conservative kidney management, pain, psychological distress, quality of life,
Co-Authors Agung Wahyu Hidayat Darmayani, Aritantri E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Faisal, Edward Fitrianti, Fita Irawan, Cophiadi Kemal Fariz Kalista, Kemal Fariz Leonard Nainggolan Putranto, Rud Putri, Chintia Dyah Ayuning Ridho, Muhammad Ihsan