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GANGGUAN PENDENGARAN AKIBAT BISING PENGGUNAAN HEADPHONE/EARPHONE: Noise Induce Hearing Loss Due to Usage of Headphone/Earphone Hendradewi, Sarwastuti; Setiamika, Made; Sudrajad, Hadi; Kandhi, Putu Wijaya; Primadewi, Novi; Pratiwi, Dewi; Yusuf, Destar Aditya
Jurnal Pengabdian Masyarakat Medika Vol 3. No. 2, September 2023
Publisher : Universitas Muhamamdiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jpmmedika.v3i2.1274

ABSTRAK Gangguan pendengaran akibat bising (GPAB) sering dijumpai pada usia pelajar. Adanya kemajuan alat elektronik beserta kemudahan dalam mengakses internet dan sosial media menyebabkan pelajar sering menggunakan personal listening device seperti headphone/earphone untuk mengakses informasi dari piranti elektronik tersebut. Identifikasi gangguan pendengaran secara dini dan intervensi yang sesuai terbukti dapat mencegah konsekuensi tersebut. Tujuan diselenggarakan kegiatan ini adalah untuk memberikan edukasi gangguan pendengaran akibat bising (GPAB) dan untuk mengetahui sejak dini kondisi telinga dan pendengaran pelajar dan memberikan intervensi dan tatalaksana sesuai kebutuhan. Metode dalam kegiatan ini direncanakan dilakukan melalui tahapan - tahapan sesuai dengan petunjuk pengendalian HIRARC (hazard identification, risk assessment, and risk control). Hasil kegiatan ini didapatkan pendengaran 147 siswa dalam batas normal, 31 siswa terdapat serumen, 7 siswa Otitis Eksterna, 3 siswa OMSK, dan 4 orang siswa dicurigai menderita gangguan pendengaran akibat bising. Siswa yang dicurigai menderita gangguan pendengaran akibat bising dianjurkan ke RSUD Dr. Moewardi Surakarta untuk dilakukan pemeriksaan dan tatalaksana lebih lanjut. ABSTRACT Noise induce hearing loss (NIHL) is often found in students. The advancement of electronic devices along with the ease of accessing the internet and social media has caused students to often use personal listening devices such as headphones/earphones to access information from these electronic devices. Early identification of hearing loss and appropriate intervention have been shown to prevent such consequences. The purpose of this activity was to educate noise induce hearing loss (NIHL) and to know early on the ear and hearing condition of students and provided intervention and management as needed. The method in this activity was planned to be carried out through stages in accordance with the HIRARC (Hazard Identification, Risk Assessment, and Risk Control) control instructions. The results of this activity obtained the hearing of 147 students within normal limits, 31 students with cerumen, 7 Otitis Externa students, 3 OMSK students, and 4 students with suspect of noise induce hearing loss. Students who were suspected of suffering from hearing loss due to noise were recommended to Dr. Moewardi Surakarta Hospital for further examination and management.

High TNF-α Levels in Active Phase Chronic Suppurative Otitis Media Caused by Gram-positive Bacteria Dewi, Marisa Rizqiana; Pratiwi, Dewi; Kandhi, Putu Wijaya
Molecular and Cellular Biomedical Sciences Vol 7, No 2 (2023)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v7i2.321

Background: Chronic suppurative otitis media (CSOM) is a persistent inflammatory disease of the middle ear and mastoid cavity caused by pathogenic infection. CSOM has a fairly high incidence in developing countries and is the main cause of acquired hearing loss in children. Tumor necrosis factor alpha (TNF-α) is a significant inflammatory mediator in CSOM. This study aimed to analyze TNF-α levels in ear discharge and blood serum in active phase CSOM caused by Gram-positive and Gram-negative bacteria.Materials and Methods: This research was an analytical observational study with a cross sectional design. Blood serum and ear discharge from CSOM patients were used in this study. Blood serum and ear discharge TNF-α levels were measured using enzyme-linked immunosorbent assay.Results: From 26 CSOM subjects, 13 subjects were infected with Gram-positive bacteria and the 13 others were infected with Gram-negative bacteria. The majority of the subjects were male (53.8%) with an age range from 36-45 years (42.3%). The most common species of bacteria was Pseudomonas aeruginosa. Blood serum and ear discharge TNF-α levels were higher in samples that contained Gram-positive bacteria.Conclusion: TNF-α levels in active phase CSOM caused by Gram-positive bacteria are higher than those which are caused by Gram-negative bacteria.Keywords: chronic suppurative otitis media, TNF-α, gram-positive, gram-negative

Adaptation of Chronic Otitis Media Questionnaire (COMQ-12): reability and validity of the Indonesian version Sudrajad, Hadi; Hendradewi, Sarwastuti; Primadewi, Novi; Kandhi, Putu Wijaya; Seytopambudi, Kukuh
Oto Rhino Laryngologica Indonesiana Vol. 54 No. 2 (2024): VOLUME 54, NO. 2 JULY - DECEMBER 2024
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v54i2.688

Background: Chronic suppurative otitis media (CSOM) is one of the most common ear diseases that has a major impact on quality of life (QoL). The Chronic Otitis Media Questionnaire 12 (COMQ-12) is a CSOM-specific questionnaire that aims to assess QoL. Until currently, there is no questionnaire that has been tested for reliability and validity in the Indonesian version. Purpose: To assess the reliability and validity of the Indonesian version of COMQ-12. Method: An analytic observational study with a cross-sectional design, conducted in Dr. Moewardi General Hospital Surakarta Indonesia from March to May 2024. Reliability was assessed by internal consistency, and validity was assessed by Pearson correlation. Result: The reliability test with internal consistency obtained Cronbach’s alpha value for all question items >0.7. This indicated that all question items had good reliability. Meanwhile, the validity test with the Pearson correlation test obtained a p-value <0.05 for all question items with coefficients, all of which were positive. This indicated that all question items had good validity. Conclusion: Indonesian version of COMQ-12 has good reliability and validity to assess QoL in CSOM patients. Keywords: CSOM, COMQ-12, QoL, reliability, validity ABSTRAK Latar belakang: Otitis media supuratif kronik (OMSK) merupakan salah satu penyakit telinga yang paling umum dijumpai, dan berdampak besar pada kualitas hidup (QoL). Kuesioner Otitis Media Kronik 12 (COMQ-12) merupakan kuesioner khusus Otitis Media Supuratif Kronik (OMSK) yang bertujuan untuk menilai QoL, namun saat ini kuesioner COMQ-12 dalam versi Bahasa Indonesia belum teruji reliabilitas dan validitasnya. Tujuan: Untuk menilai reliabilitas dan validitas COMQ- 12 versi Bahasa Indonesia. Metode: Penelitian observasi analitik dengan desain potong lintang, yang dilakukan di RSUD Dr. Moewardi Surakarta, Indonesia dari bulan Maret sampai Mei 2024. Reliabilitas dinilai dengan konsistensi internal, dan validitas dinilai dengan korelasi Pearson. Hasil: Uji reliabilitas dengan konsistensi internal memperoleh nilai Cronbach’s alpha untuk semua butir soal >0,7. Hal ini menunjukkan bahwa semua butir soal memiliki reliabilitas yang baik. Sementara itu, uji validitas dengan uji Pearson correlation memperoleh nilai p<0,05 untuk semua butir soal, dengan koefisien yang semuanya positif. Hal ini menunjukkan bahwa semua butir soal memiliki validitas yang baik. Kesimpulan: COMQ-12 versi Indonesia mempunyai reliabilitas dan validitas yang baik untuk menilai kualitas hidup pasien OMSK.

Antioxidant Ability of the 2% Indonesian Mount Lawu Propolis Ear Drops Sudrajad, Hadi; Setiamika, Made; Hendradewi, Sarwastuti; Primadewi, Novi; Kandhi, Putu Wijaya; Pratiwi, Dewi; Kesumo, Aningdita; Pratiwi, Primadita Asis
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.53208

Propolis ear drops are natural antioxidants that have been developed for various health purposes. There are many types of propolis ear drops available today, including the Indonesian Mount Lawu Propolis ear drop (IMLPED). Indonesian Mount Lawu Propolis ear drop is proven to contain many antioxidant substances such as flavonoids, phenolic acids, caffeic acid pethyl ester, and quercetin. However, to date, no study has assessed the antioxidant activity of IMLPED, especially the 2% IMLPED. This study aims to assess the antioxidant activity of the 2% IMLPED. This is an in vitro study to assess the antioxidant activity of the 2% IMLPED with 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) method based on the inhibitory concentration at 50% (IC50) value. The IC50 represents the concentration required to reduce 50% of the free radicals. The result of this study showed that the IC50 value of the 2% IMLPED is 30.71 µg/mL. Based on the IC50 value, the 2% IMLPED formula exhibits a robust antioxidant effect. The implications of this revelation establish IMLPED as a promising candidate in combating oxidative stress.

Salivary pepsin detection for laryngopharyngeal reflux diagnosis: sensitivity and specificity comparison with scoring system: Salivary pepsin detection for LPR diagnosis Kandhi, Putu Wijaya; Manurung, Rosauli; Wicaksono, Pandu
Oto Rhino Laryngologica Indonesiana Vol. 55 No. 1 (2025): VOLUME 55, NO. 1 JANUARY - JUNE 2025
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v55i1.722

Background: Laryngopharyngeal reflux (LPR) is characterized by the backflow of stomach contents into the larynx and pharynx. Gastroesophageal reflux disease (GERD) is a similar condition often mistaken for LPR. Detection of oral salivary pepsin has been developed as an alternative diagnostic modality for LPR. Additionally, there are diagnostic aids for LPR utilizing scoring systems, namely Reflux Symptoms Score (RSS) and Reflux Sign Assessment (RSA). Purpose: To assess the sensitivity and specificity of saliva pepsin testing compared to RSS and RSA in diagnosing LPR. Method: A prospective cross-sectional study involving 30 subjects with LPR symptoms was conducted to evaluate the diagnostic accuracy of saliva pepsin levels compared to RSS and RSA scores in LPR patients. Diagnostic tests performed included sensitivity, specificity, Positive Predictive Value (PPV), and Negative Predictive Value (NPV). Result: The male-to-female ratio was 1:1.3. Saliva pepsin testing with a cutoff value of ≥16 ng/mL, demonstrated a sensitivity of 100%, specificity of 90%, PPV of 95.24%, and NPV of 100% against the RSS questionnaire. Meanwhile, when assessed against the RSA questionnaire, saliva pepsin testing showed a sensitivity of 95.24%, specificity of 88.89%, PPV of 95.24%, and NPV of 88.89%. The results indicated that saliva pepsin testing had good sensitivity and specificity, with values of 100% and 90%, respectively, against the RSS questionnaire; and 95.24% and 88.98%, respectively, against the RSA questionnaire. Conculsion: Saliva pepsin testing could be used as a primary diagnostic modality in the future due to its non-invasive nature, ease of administration, and good patient tolerance.

Effect Of Vitamin C On Tnf-Alpha Expression In Recurrent Tonsillitis At Rsud Dr. Moewardi Kandhi, Putu Wijaya
Indonesian Basic and Experimental Health Sciences Vol. 12 No. 2 (2024): April
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol12iss2pp59-62

Background: The immunopathogenesis of tonsillitis is thought to be due to the involvement of various proinflammatory cytokines including tumor necrosis factor α (TNF-α). Considering the role of TNF-α in the immunopathogenesis of tonsillitis, various interventions have been carried out both surgically and with drugs. Vitamin C, which is one of the important micronutrients in the body, has a role as an antioxidant and immunomodulator so that its administration is thought to be able to overcome the increase in TNF-α during the disease process. This study aims to determine the effect of vitamin C administration on TNF-α levels in patients with recurrent tonsillitis at Dr. Moewardi Hospital. Methods: This study is an experimental quantitative study using Randomized Controlled Trials research design with non-blinding. Samples in the study were divided into two treatment groups, namely treatment with oral vitamin C and placebo 50mg/kg body weight/day which then measured serum TNF-α levels. Results: The average TNF-α level in the Vitamin C group was smaller at 110.72 pg/mL compared to the control group which amounted to 148.96 pg/mL. The results of the independent t-test of TNF-α levels in both groups obtained a significant value <0.05, which was 0.037. This means that there is a significant difference in TNF-α levels between the two treatment groups. Conclusions: Vitamin C administration before tonsillectomy in patients with recurrent tonsillitis can significantly reduce TNF-α levels compared to the control group. This opens the possibility of routine use of vitamin C in recurrent tonsillitis patients to get better treatment results.

Adaptation of Chronic Otitis Media Questionnaire (COMQ-12): reability and validity of the Indonesian version Sudrajad, Hadi; Hendradewi, Sarwastuti; Primadewi, Novi; Kandhi, Putu Wijaya; Seytopambudi, Kukuh
Oto Rhino Laryngologica Indonesiana Vol. 54 No. 2 (2024): VOLUME 54, NO. 2 JULY - DECEMBER 2024
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v54i2.688

Background: Chronic suppurative otitis media (CSOM) is one of the most common ear diseases that has a major impact on quality of life (QoL). The Chronic Otitis Media Questionnaire 12 (COMQ-12) is a CSOM-specific questionnaire that aims to assess QoL. Until currently, there is no questionnaire that has been tested for reliability and validity in the Indonesian version. Purpose: To assess the reliability and validity of the Indonesian version of COMQ-12. Method: An analytic observational study with a cross-sectional design, conducted in Dr. Moewardi General Hospital Surakarta Indonesia from March to May 2024. Reliability was assessed by internal consistency, and validity was assessed by Pearson correlation. Result: The reliability test with internal consistency obtained Cronbach’s alpha value for all question items >0.7. This indicated that all question items had good reliability. Meanwhile, the validity test with the Pearson correlation test obtained a p-value <0.05 for all question items with coefficients, all of which were positive. This indicated that all question items had good validity. Conclusion: Indonesian version of COMQ-12 has good reliability and validity to assess QoL in CSOM patients. Keywords: CSOM, COMQ-12, QoL, reliability, validity ABSTRAK Latar belakang: Otitis media supuratif kronik (OMSK) merupakan salah satu penyakit telinga yang paling umum dijumpai, dan berdampak besar pada kualitas hidup (QoL). Kuesioner Otitis Media Kronik 12 (COMQ-12) merupakan kuesioner khusus Otitis Media Supuratif Kronik (OMSK) yang bertujuan untuk menilai QoL, namun saat ini kuesioner COMQ-12 dalam versi Bahasa Indonesia belum teruji reliabilitas dan validitasnya. Tujuan: Untuk menilai reliabilitas dan validitas COMQ- 12 versi Bahasa Indonesia. Metode: Penelitian observasi analitik dengan desain potong lintang, yang dilakukan di RSUD Dr. Moewardi Surakarta, Indonesia dari bulan Maret sampai Mei 2024. Reliabilitas dinilai dengan konsistensi internal, dan validitas dinilai dengan korelasi Pearson. Hasil: Uji reliabilitas dengan konsistensi internal memperoleh nilai Cronbach’s alpha untuk semua butir soal >0,7. Hal ini menunjukkan bahwa semua butir soal memiliki reliabilitas yang baik. Sementara itu, uji validitas dengan uji Pearson correlation memperoleh nilai p<0,05 untuk semua butir soal, dengan koefisien yang semuanya positif. Hal ini menunjukkan bahwa semua butir soal memiliki validitas yang baik. Kesimpulan: COMQ-12 versi Indonesia mempunyai reliabilitas dan validitas yang baik untuk menilai kualitas hidup pasien OMSK.

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