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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Pengabdian Masyarakat Medika Biocaster : Jurnal Kajian Biologi
Setiamika, Made
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Immunology & microbiology Medicine & Pharmacology Public Health

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GANGGUAN PENDENGARAN AKIBAT BISING PENGGUNAAN HEADPHONE/EARPHONE: Noise Induce Hearing Loss Due to Usage of Headphone/Earphone Hendradewi, Sarwastuti; Setiamika, Made; Sudrajad, Hadi; Kandhi, Putu Wijaya; Primadewi, Novi; Pratiwi, Dewi; Yusuf, Destar Aditya
Jurnal Pengabdian Masyarakat Medika Vol 3. No. 2, September 2023
Publisher : Universitas Muhamamdiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jpmmedika.v3i2.1274

Abstract

ABSTRAK Gangguan pendengaran akibat bising (GPAB) sering dijumpai pada usia pelajar. Adanya kemajuan alat elektronik beserta kemudahan dalam mengakses internet dan sosial media menyebabkan pelajar sering menggunakan personal listening device seperti headphone/earphone untuk mengakses informasi dari piranti elektronik tersebut. Identifikasi gangguan pendengaran secara dini dan intervensi yang sesuai terbukti dapat mencegah konsekuensi tersebut. Tujuan diselenggarakan kegiatan ini adalah untuk memberikan edukasi gangguan pendengaran akibat bising (GPAB) dan untuk mengetahui sejak dini kondisi telinga dan pendengaran pelajar dan memberikan intervensi dan tatalaksana sesuai kebutuhan. Metode dalam kegiatan ini direncanakan dilakukan melalui tahapan - tahapan sesuai dengan petunjuk pengendalian HIRARC (hazard identification, risk assessment, and risk control). Hasil kegiatan ini didapatkan pendengaran 147 siswa dalam batas normal, 31 siswa terdapat serumen, 7 siswa Otitis Eksterna, 3 siswa OMSK, dan 4 orang siswa dicurigai menderita gangguan pendengaran akibat bising. Siswa yang dicurigai menderita gangguan pendengaran akibat bising dianjurkan ke RSUD Dr. Moewardi Surakarta untuk dilakukan pemeriksaan dan tatalaksana lebih lanjut.   ABSTRACT Noise induce hearing loss (NIHL) is often found in students. The advancement of electronic devices along with the ease of accessing the internet and social media has caused students to often use personal listening devices such as headphones/earphones to access information from these electronic devices. Early identification of hearing loss and appropriate intervention have been shown to prevent such consequences. The purpose of this activity was to educate noise induce hearing loss (NIHL) and to know early on the ear and hearing condition of students and provided intervention and management as needed. The method in this activity was planned to be carried out through stages in accordance with the HIRARC (Hazard Identification, Risk Assessment, and Risk Control) control instructions. The results of this activity obtained the hearing of 147 students within normal limits, 31 students with cerumen, 7 Otitis Externa students, 3 OMSK students, and 4 students with suspect of noise induce hearing loss. Students who were suspected of suffering from hearing loss due to noise were recommended to Dr. Moewardi Surakarta Hospital for further examination and management.
Antioxidant Ability of the 2% Indonesian Mount Lawu Propolis Ear Drops Sudrajad, Hadi; Setiamika, Made; Hendradewi, Sarwastuti; Primadewi, Novi; Kandhi, Putu Wijaya; Pratiwi, Dewi; Kesumo, Aningdita; Pratiwi, Primadita Asis
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.53208

Abstract

Propolis ear drops are natural antioxidants that have been developed for various health purposes. There are many types of propolis ear drops available today, including the Indonesian Mount Lawu Propolis ear drop (IMLPED). Indonesian Mount Lawu Propolis ear drop is proven to contain many antioxidant substances such as flavonoids, phenolic acids, caffeic acid pethyl ester, and quercetin. However, to date, no study has assessed the antioxidant activity of IMLPED, especially the 2% IMLPED. This study aims to assess the antioxidant activity of the 2% IMLPED. This is an in vitro study to assess the antioxidant activity of the 2% IMLPED with 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) method based on the inhibitory concentration at 50% (IC50) value. The IC50 represents the concentration required to reduce 50% of the free radicals. The result of this study showed that the IC50 value of the 2% IMLPED is 30.71 µg/mL. Based on the IC50 value, the 2% IMLPED formula exhibits a robust antioxidant effect. The implications of this revelation establish IMLPED as a promising candidate in combating oxidative stress.
The Role of Interleukin 1β, Fibroblast Growth Factor, Fibroblasts, Keratinocytes, Granulation Tissue and Collagen Density in the Wound Healing Phase (Study of Wound Healing in the Inflammation, Proliferation, and Remodeling Phases) Christanto, Antonius; Cilmiaty, Risya; Setiamika, Made; Yudhani, Ratih Dewi; Dirgahayu, Paramasari; Pamungkasari, Eti Poncorini; Nurwati, Ida
Biocaster : Jurnal Kajian Biologi Vol. 5 No. 3 (2025): July
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/biocaster.v5i3.399

Abstract

This scoping review explores the roles of interleukin 1β, fibroblast growth factor, fibroblasts, keratinocytes, granulation tissue, and collagen density in the wound healing process, focusing on inflammation, proliferation, and remodeling phases. A systematic literature search identified studies investigating molecular and cellular mechanisms involved in wound repair. Findings reveal that fibroblast-derived exosomes carrying miR-93-5p inhibit autophagy, delaying diabetic wound healing. Controlled growth factor delivery enhances angiogenesis, fibroblast proliferation, and collagen deposition, accelerating tissue regeneration. SPRR1B+ keratinocytes facilitate rapid re-epithelialization, while granulation tissue provides essential scaffolding for cell migration and neovascularization. Elevated IL-1β impairs healing by increasing matrix metalloproteinases, degrading collagen. Natural compounds like red fruit oil and Binahong leaf extract promote angiogenesis and collagen synthesis. Genetic variations in inflammatory cytokines influence healing outcomes, indicating potential for personalized therapies. This review consolidates current evidence, providing insights into cellular and molecular interactions critical for effective wound repair and guiding future regenerative medicine strategies.
Co-Authors Christanto, Antonius Dewi Pratiwi Eti Poncorini Pamungkasari Hadi Sudrajad Hendradewi, Sarwastuti Ida Nurwati Kandhi, Putu Wijaya Kesumo, Aningdita Novi primadewi Paramasari Dirgahayu Pratiwi, Primadita Asis Risya Cilmiaty, Risya Yudhani, Ratih Dewi Yusuf, Destar Aditya