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All Journal Jurnal Fisika
Asyrafi, Hilman
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Physics

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Identification of Brain Areas Associated with Chronic Neuropathic Pain through Hjorth Parameter Analysis of EEG Signals Asyrafi, Hilman; Handayani, Nita; Ilmawan, Lutfi Budi; Shabir, Fadly; Jamal, Ridwan; Jannah, Miftahul; Arysespajayadi
Jurnal Fisika Vol. 15 No. 2 (2025): Jurnal Fisika 15 (2) 2025
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jf.v15i2.24512

Abstract

This study investigates the neurophysiological signatures of chronic neuropathic pain (CNP) through the analysis of EEG signals using Hjorth parameters (Activity, Mobility, and Complexity). We compared EEG recordings from 36 CNP patients with those from 19 healthy controls (HC) under both eyes-open and eyes-closed conditions. Analysis of 19 electrode locations revealed significant differences between the groups across all Hjorth parameters. The Activity parameter showed dramatic elevations in CNP patients across all brain regions, indicating widespread cortical hyperexcitability. Mobility parameters revealed significant alterations particularly in occipital (O2), central midline (Cz), and parietal (Pz) regions, with strong effect sizes (Cliff's delta > 0.7). Complexity parameters demonstrated significant changes in right temporal (T4) and parietal midline (Pz) areas. The combined analysis identified the parietal cortex, temporal regions, occipital cortex, and central midline as key areas associated with CNP, suggesting a distributed network disruption rather than localized dysfunction. These findings contribute to our understanding of the neural mechanisms underlying chronic neuropathic pain and may support the development of objective diagnostic markers and targeted interventions for this debilitating condition.
Co-Authors Arysespajayadi Handayani, Nita Jamal, Ridwan Lutfi Budi Ilmawan, Lutfi Budi Miftahul Jannah Shabir, Fadly