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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Farmasi Sains dan Komunitas Natural Sciences Engineering and Technology Journal Media Farmasi Indonesia

Wahyuning Setyani

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Author-ID : 2387315

Aerospace Engineering Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Electrical & Electronics Engineering Energy Immunology & microbiology Industrial & Manufacturing Engineering Library & Information Science Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Physics Social Sciences Transportation Other

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Articles

UJI DAYA ANTIBAKTERI DAN IDENTIFIKASI ISOLAT SENYAWA KATEKIN DARI DAUN TEH (Camellia sinensisL. var Assamica) Christina Astutiningsih; Wahyuning Setyani; Himawan Hindratna
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 2 (2014)
Publisher : Sanata Dharma University

Abstract: Antibacterial is a substance that can interfere with the growth and metabolism of bacteria, sothat these substances can inhibit growth or even kill bacteria. This research aimed to utilize naturalmaterials as a natural antibacterial. This study investigated the ability of isolates catechins of tea leaves toinhibit Staphylococcus aureus and spectral identification of these catechins. Catechin compounds wasextracted by water, and then fractionated with CHCl3 and ethyl acetate. Ethyl acetate phase wasconcentrated fractionation results using a rotary evaporator for further separation using thin layerchromatography with various mobile. The results of the study showed that the concentration of isolates ofdemonstrated to be effective as antibacterial, with MIC 12.5%. UV spectrum measurement showed that theisolates had a maximum absorption at a wavelength of 279 nm while the FTIR spectrophotometer showedthat isolates catechin-containing functional groups C = C aromatic absorption 1500-1600 nm^-1 and OHgroups, a broad band between 2000 and 3600 nm^-1.Key words: isolates catechins, Staphylococcus aureus, tea leaves, antibacterial

POTENSI NANOKOLAGEN LIMBAH SISIK IKAN SEBAGAI COSMECEUTICAL Hanny Setyowati; Wahyuning Setyani
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 12, No 1 (2015)
Publisher : Sanata Dharma University

Abstract: Collagen is the most abundant protein of white connective tissue, comprising approximately 30% of total animal protein. This is a fibrous protein which give strength and flexibility in the tissue and bone, also playing an important role for skin and tendon. The utilization of collagen from fish scales waste become an alternative for medication (pharmaceutical), and daily care as cosmetic, which known by cosmeceutical. Nanotechnology application can be completing of cosmeceutical, not only for cure, but also for daily treatment using an wasted materials changed into beneficial product to be developed. Keywords : collagen, fish scales waste, cosmeceutical

KRIM KULIT BUAH DURIAN (Durio zibethinus L.) SEBAGAI OBAT HERBAL PENGOBATAN INFEKSI JAMUR Candida albicans Hanny Setyowati; Hananun Zharfa Hanifah; Rr Putri Nugraheni; Wahyuning Setyani
Media Farmasi Indonesia Vol. 8 No. 2 (2013): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (286.716 KB)

Durian rind (Durio zibethinus L.) is a part of plant reported to have antifungal activity toward Candida albicans fungi. This research aimed to make extract rind of D. zibethinus L. formula cream and evaluated the physical characteristic toward C. albicans. The formulation of extract rind of D. zibethinus L. is made based on preliminary test with variety of extract concentration, which is 15%, 20%, and 25%. Negative control used basis cream consisting of emulgide, paraffinum liquidum, and aquadest, whereas positive control used Ketoconazole 2%. Cream produced was further tested for: organoleptic,homogeneity, adhesive power, dispersive power, and protection power. Antifungal activity tested is done by diffusion method. Antifungal activities data are analyzed by one way ANOVA. The result of this research showed that extract rind of D. zibethinus L. contains saponin, flavonoid, and tannin which is the formulation in cream had antifungal activities towards C. albicans with average resistibility zone diameter for 15% (0,62 cm) extract concentration, 20% (0,73 cm) extract concentration, and 25% (0,81 cm) extract concentration.

UJI EFEK ANTIINFLAMASI FRAKSI ETIL ASETAT EKSTRAK ALFAFA (Medicago sativa) PADA TIKUS PUTIH JANTAN YANG DIINDUKSI KARAGENIN Lia Kusmita; Wahyuning Setyani; Ika Puspitaningrum
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Perkembangan Terbaru Pemanfaatan Herbal Sebagai Agen Preventif Pada Tera
Publisher : Universitas Wahid Hasyim Semarang

ABSTRAK Inflamasi (radang) adalah reaksi setempat dari jaringan hidup atau sel terhadap suatu rangsang atau injury (cidera atau jejas). Penelitian ini bertujuan untuk mengetahui aktivitas antiinflamasi fraksi etil asetat ekstrak herba alfafa (Medicago sativa) terhadap salah satu parameter inflamasi yaitu pembengkakan pada kaki tikus dengan induksi karagenin 1%. Selain itu, penelitian ini juga bertujuan untuk mengetahui dosis efektif dari fraksi etil asetat ekstrak herba alfafa sebagai antiinflamasi. Penelitian ini menggunakan hewan uji tikus jantan galur Wistar sebanyak 25 ekor dibagi 5 kelompok. Kelompok I (kontrol negatif) Na CMC 0,5%, kelompok II (kontrol positif) natrium diklofenak 6,3 mg/kgBB tikus, serta kelompok III, IV dan V suspensi fraksi etil asetat ekstrak alfafa 6,3; 12,6 dan 25,2 mg/kgBB tikus. Inflamasi (radang) pada tikus dengan cara diinduksi karagenin 1% sebanyak 0,10 ml. Volume udema setiap jam diketahui dari selisih volume telapak kaki pada jam-jam tertentu dengan volume kaki normal. Nilai AUC volume udema dihitung dengan metode trapezoid tiap satu jam dan dihitung % daya anti inflamasi (DAI). Nilai AUC volume udema yang diperoleh dianalisa statistik dengan uji Kruskal-Wallis dan Mann-Whitney menggunakan SPSS release 16. Hasil penelitian menunjukkan fraksi etil asetat ekstrak alfafa dapat menurunkan volume udema kaki tikus putih jantan galur Wistar yang diinduksi karagenin dengan dosis efektif sebesar 6,3 mg/ kgBB tikus dan daya antiinflamasi sebesar 20,95%. Kata kunci: alfafa, antiinflamasi, fraksi etil asetat

EFEK ANALGETIK ANTIPIRETIK EKSTRAK ETANOL KULIT BUAH MANGGIS (Garcinia mangostana L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR Ika Puspitaningrum; Lia Kusmita; Wahyuning Setyani
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL.11 NO.1 JUNI 2014
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Antipyretic analgesic is a compound that can relieve pain and can reduce fever. One of the plants that has potential as antipyretic analgesic is mangosteen (Garcinia mangostana L.). Mangosteen peel contains flavonoids and alkaloids that may have an effect as an analgesic. In addition, flavonoids could inhibit prostaglandin that has antipyretic effect. This study aims to determine the antipyretic analgesic effect of ethanol extract of mangosteen peel and the effective dose. Analgesic and antipyretic test using 25 male Wistar rats were divided 5 groups , I (negative control) CMC Na 0,5 % , II (positive control) paracetamol 50 mg/kg body weight, and III, IV and V suspension of the ethanol extract of the skin manggis 50; 100 and 200 mg/kg body weight. Pain stimuli by dipping a rat tail in the water temperature of 40° C for 10 seconds. Rat response to a painful stimulus done prior to treatment (normal response), and 30 minutes after treatment. While excitatory fever in rat by injection of 0.2 ml vaccine DPT are intramuscular. Rectal temperature of rat were measured before treatment (initial temperature), 60 minutes after the vaccine, as well as 30 minutes after treatment . Rat response to a painful stimulus and a rectal temperature of rat was analyzed using SPSS statistical release 16 . The results showed that the ethanol extract of mangosteen peel can improve the rat response to pain stimulation and lower the temperature of the mice vaccinated fever DPT. The effective dose of ethanol extract of mangosteen peel as antipyretic analgesic is 50 mg / kg body weight.Keywords: mangosteen skin, analgesics, antipyretics

PEMANFAATAN EKSTRAK ETANOL DAUN SOM JAWA SEBAGAI OBAT HERBAL ANTIKEPUTIHAN DALAM SEDIAAN SABUN CAIR Erna Prasetyaningrum; Ririn Suharsanti; Wahyuning Setyani
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Perkembangan Terbaru Pemanfaatan Herbal Sebagai Agen Preventif Pada Tera
Publisher : Universitas Wahid Hasyim Semarang

ABSTRAK Telah dilakukan penelitian mengenai formulasi sabun cair dengan ekstrak daun som jawa berbagai konsentrasi. Penelitian ini bertujuan untuk mengetahui kualitas ekstrak etanol daun som jawa sebagai obat herbal antikeputihan dalam sediaan sabun cair, mengetahui aktivitas antijamur sediaan terhadap Candida albicans dan mengetahui konsentrasi ekstrak daun som jawa yang efektif sebagai bahan jamur dalam sediaan sabun cair. Pengujian kualitas sabun cair telah disesuaikan dengan aturan Standar Nasional Indonesia (SNI) yang meliputi pengamatan skrining fitokimia, organoleptis, pH, viskositas, bj selama waktu penyimpanan. Dari hasil penelitian kestabilan fisika, kimia dan mikrobiologi diketahui bahwa sabun cair ekstrak daun som jawa relatif stabil selama penyimpanan. Hasil penelitian menyimpulkan bahwa uji organoleptis dari sediaan kurang nyaman jika dipakai karena bau dan warna yang tidak menarik. Sedangkan pada uji pH konsentrasi 30%,40% dan 50% memenuhi persyaratan lebih dari 8, viskositas dan bobot jenis sediaan memenuhi syarat lebih dari 1,01-1,10. Uji aktivitas antijamur menunjukkan hasil yang positif pada konsentrasi 40% dan 50 % yang diujikan. Kata kunci: antijamur, antikeputihan, Candida albicans, daun som jawa, sabun cair

Factorial Design Optimization of Antioxidant Cream from Kepok Banana Peel Extract: Formulation, Characterization, and Stability Evaluation Gabriella Sharen Allolinggi; Wahyuning Setyani
Natural Sciences Engineering and Technology Journal Vol. 5 No. 1 (2025): Natural Sciences Engineering and Technology Journal
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/nasetjournal.v5i1.64

Kepok banana peel, a rich source of flavonoids and phenols with potent antioxidant activity, presents a promising natural ingredient for topical applications. This study aimed to optimize the formulation of an antioxidant cream using kepok banana peel ethanol extract, focusing on the emulsifier combination of stearic acid and triethanolamine (TEA) for enhanced physical properties and stability. A two-factor, two-level factorial design was employed to investigate the effects and interactions of stearic acid and TEA concentrations on the cream's organoleptic characteristics, homogeneity, pH, viscosity, and spreadability. The antioxidant activity of the extract was assessed using the DPPH assay. The optimal formula was determined using Design Expert 13 software with ANOVA at a 95% confidence level. The ethanol extract exhibited strong antioxidant activity (IC50 84.25 ppm). The optimal cream formulation, containing 10 grams of stearic acid and 2 grams of TEA, demonstrated desirable physical properties, including smooth texture, homogenous appearance, and excellent spreadability, meeting the criteria for a stable and effective topical product. In conclusion, Kepok banana peel extract holds significant potential as a natural antioxidant for topical applications. The optimized cream formulation, achieved through factorial design, provides a stable and effective delivery system for harnessing the therapeutic benefits of this natural extract.

Co-Authors Christina Astutiningsih erna prasetyaningrum Gabriella Sharen Allolinggi Hananun Zharfa Hanifah Hanny Setyowati Himawan Hindratna Ika Puspitaningrum Ika Puspitaningrum Lia Kusmita Ririn Suharsanti Rr Putri Nugraheni

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