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All Journal Jurnal Farmasi Indonesia JURNAL INOVASI DAN PENGABDIAN MASYARAKAT INDONESIA Journal of Tropical Pharmacy and Chemistry
Ika Puspitaningrum
Sekolah Tinggi Ilmu Farmasi Yayasan Pharmasi Semarang
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Efek Antihiperkolesterolemia Ekstrak Etanol Herba Alfafa (Medicago sativa) Pada Tikus Putih Jantan Ika Puspitaningrum; Lia Kusmita; Wahyuning Setyani
Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (93.39 KB) | DOI: 10.31001/jfi.v13i1.96

Abstract

Hypercholesterolemia is a disorder characterized by an increased concentration of cholesterol in the blood. Alfalfa (Medicago sativa) is one of the plants that are believed to control blood cholesterol. This study aims to determine antihypercholesterolemia effect of herb alfafa ethanol extract and the effective dose. Test antihypercholesterolemia ethanol extract of herb alfalfa using male Wistar rats as many as 30 individuals were divided into 6 groups. Group 1 (normal control) was given standard feed. Group 2 (negative control) was given CMC Na 0,5%. Group 3 (positive control) was given Simvastatin. Groups 4, 5 and 6 was given herb alfafa ethanol extract 270, 540 and 1080 mg/kg rat. All treatments are given 7 days orally. Induction hypercholesterolemia with high-fat feed a mixture of standard rat food with lard and egg yolk duck (3:1), as well as fructose 1.8 g/kg rat. Induction was given to all groups for 50 days, except for the normal control. Measurement of total blood cholesterol levels was done on days 0, 51 and 58. Cholesterol levels were obtained calculated % decline further tested with SPSS statistical release 16. The test results showed a statistically significant difference between the negative control group with the ethanol extract of herb Alfalfa three doses. While the comparison between the positive control with the ethanol extract of the herb alfalfa three doses showed no significant differences. It was provided that the ethanol extract of the herb alfalfa could affected antihypercholesterolemia, but not comparable to Simvastatin. The effective dose of ethanol extract of alfalfa as antihypercholesterolemia was 270 mg/kg rat.
Edukasi Pemanfaatan Kosmetik Herbal Dan Pembuatan Sabun Beras Pada Kader PKK Desa Ungsari Rizki Eka Purwanto; Mutmainah; Siti Munisih; I Kadek Bagiana; Yuvianti Dwi Franyoto; Aries Koes Soendoro; Maria Caecilia Nanny Setiawati H; Sri Haryanti; Lia Kusmita; Ika Puspitaningrum
JURNAL INOVASI DAN PENGABDIAN MASYARAKAT INDONESIA Vol 2 No 2 (2023): April
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jipmi.v2i2.100

Abstract

Latar belakang: Desa Dukuh, kecamatan Delanggu merupakan salah satu Desa di Kabupaten Klaten, Jawa Tengah yang terkenal akan produksi berasnya. Inovasi yang dapat diberikan untuk meningkatkan potensi dan nilai tambah dari beras adalah diformulasikan ke dalam sediaan sabun beras herbal. Tujuan: Memperkenalkan metode pengolahan beras dan tanaman herbal hingga menjadi produk sabun beras herbal yang dapat menciptakan peluang usaha desa. Metode: Kegiatan ini dilakukan melalui tiga tahapan yaitu tahapan pertama tahapan perencanaan dan persiapan kegiatan, tahapan kedua adalah pelaksanaan meliputi sosialisasi dan pelatihan pembuatan sabun beras herbal dan tahap ketiga adalah evaluasi akhir. Hasil: Hasil pelaksanaan kegiatan pengabdian masyarakat diterima dengan antusias dan seluruh peserta aktif dalam kegiatan sosialisasi mengenai kosmetik herbal dan pelatihan pembuatan sabun beras herbal. Lebih dari 90% peserta memahami sosialisasi dan pelatihan yang diberikan. Kesimpulan: Kegiatan pengabdian masyarakat yang berlangsung sukses dan lancar. Peserta pengabdian juga berharap kelanjutan kegiatan pelatihan kontrol kualitas sediaan sabun dan pelatihan pemasaran produk. Kata Kunci: beras, herbal, Klaten, sabun __________________________________________________________________________________________ Abstract Background: Dukuh Village, Delanggu sub-district is one of the villages in Klaten  Regency, Central Java which is famous for its rice production. An innovation that can be given to increase the potential and added value of rice is to formulate it into herbal rice soap preparations. Objective: To introduce methods of processing rice and herbal plants to become herbal rice soap products that can create village business opportunities. Method: This activity is carried out through three stages, namely the first stage is the planning stage, the second stage is the socialization and training stage for making herbal rice soap and the third stage is the final evaluation. Result: The results of the implementation of community service activities were enthusiastically received and all participants were active in socialization activities regarding herbal cosmetics and training in making herbal rice soap. More than 90% of the participants understood the socialization and training provided. Conclusion: Community service activities that took place successfully and smoothly. The participants also hope to continue the quality control training activities for soap preparations and product marketing training. Keywords: rice, herbs, Klaten, soap
Antihipercolesterolemia Effects and Acute Toxicity Test of Pheophytin on Green Tea Lia Kusmita; Ika Puspitaningrum
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 1 (2020): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i1.222

Abstract

Hypercholesterolemia is a condition characterized by increased levels of total cholesterol in the blood. Pheophytin is the result of degradation of chlorophyll which is the dominant pigment in green tea, and has been shown to have the same antioxidant properties as ?- carotene. This study aims to determine the antihypercholesterolemia effect and effective dose of pheophytin isolates and acute toxicity tests to determine the safety level of pheophytin isolates. Antihipocolesterolemia test uses induction of high-fat feed that is a mixture of standard food, pork oil and quail egg yolk (16: 3: 1). While the acute toxicity test is carried out based on OECD 423, Clinical symptoms that arise for 3 hours are observed intensively. Histopathological examination data of liver and kidney organs were performed on day 14. Data obtained in the form of LD 50 and clinical symptoms that arise as well as histopathological results were analyzed qualitatively. Statistical test results of percent reduction in total cholesterol levels showed a significant difference between the negative control group and the pheophytin isolates of the three doses. This proves that pheophytin isolates can have antihypercholesterolemic effect with an effective dose of 10 mg/kgBW. Histopathological examination results of aorta and liver of rats showed that the higher the dose of pheophytin isolates, the lighter the degree of fatty acid. While the toxicity test results showed that the LD50 value of pheophytin isolates was more than 2000 mg / kgBW (non-toxic category). However, pheophytin isolate with LD50 is more than 2000 mg/kgBW which has shown the presence of pancreatic degeneration and hydropic degeneration, but necrosis has not occurred yet.
Co-Authors Aries Koes Soendoro Etty Sulistyowati Franyoto, Yuvianti Dwi Hesti Wulan I Bagiana Lia Kusmita Lia Kusmita Lia Kusmita Lia Kusmita Maria Caecilia Nanny Setiawati H Mutmainah Mutmainah Mutmainah Siti Munisih Sri Haryanti Ungsari Rizki Eka Purwanto Uning Rininingsih EM. Wahyuning Setyani Wahyuning Setyani Yohanes Martono Yustisia Dian Advistasari