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All Journal BALI MEDICAL JOURNAL (BMJ) Medicina E-Jurnal Medika Udayana E-Jurnal Udayana Medica Berkala Ilmu Kesehatan Kulit dan Kelamin ISM (Intisari Sains Medis) : Jurnal Kedokteran Jurnal Biomedika dan Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Bali Dermatology and Venereology Journal Indonesian Journal of Global Health research Essential: Essence of Scientific Medical Journal Indian Journal of Forensic Medicine & Toxicology MAHESA : Malahayati Health Student Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Journal of Global Pharma Technology Eduvest - Journal of Universal Studies Neurona Bali Dermatology Venereology and Aesthetic Journal
Luh Made Mas Rusyati
Departemen Dermatologi Dan Venereologi, Fakultas Kedokteran Universitas Udayana/RSUP Prof. Dr. I G. N. G. Ngoerah, Denpasar, Bali, Indonesia
Aerospace Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Low plasma level of insulin-like growth factor-I (IGF-I) is a risk factor for multibacillary type of leprosy Rusyati, Luh Mas; Adiguna, Made Swastika; Wiryo, Indra Teguh
Bali Dermatology and Venereology Journal Vol 1, No 2 (2018)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (99.604 KB) | DOI: 10.15562/bdv.v1i2.12

Abstract

Introduction: Leprosy is one of infectious diseases with complex issues. Previous study showed poverty, malnutrition, lack of proper food and nutrient intake, as well as low income. Recently, many studies reported insulin-like growth factor-I (IGF-I) as excellent nutrient marker.Objective: This study aims to prove that low plasma level of insulin-like growth factor-I is a risk factor for multibacillary type of leprosy. Material and methods: This case-control study design involved 38 patients with leprosy subjects as cases and 38 control subjects. The sample collection is done by consecutive sampling and has fulfilled the inclusion and exclusion criteria which matched by age and gender in Dermatology and Venereology Outpatient clinic of Sanglah General Hosptital. The collected data was analyzed using SPSS version 23.0 with Pearson Chi square test to obtain Odds Ratio. Results: This study showed that IGF-I plasma levels in the case group were significantly lower than the control group (p<0.05) with Odds ratio for IGF-I plasma 34.61 (95% CI= 7.17-167.01, p<0.001)Conclusion: Low plasma level of insulin-like growth factor-I is a risk factor for multibacillary type of leprosy.
Interaction between leprosy and HIV infection Sudarsa, Prima; Karna, Ratih Vibriyanti; Rusyati, Luh Mas
Bali Dermatology and Venereology Journal Vol 1, No 1 (2018)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (177.161 KB) | DOI: 10.15562/bdv.v1i1.4

Abstract

Introduction: Leprosy and Human Immunodeficiency Virus (HIV) infections still count as major health issues worldwide. Starting with the HIV pandemic back in the eighties, leprosy was feared to re-emerge as the HIV cases arose. Co-infections between leprosy and HIV were worried to cause an increase in leprosy cases, with worse clinical manifestation, predominantly toward the lepromatous spectrum, decrease in therapy response, and prolonged therapy period. Unlike its interaction with tuberculosis, HIV infection was turned out to not increasing nor deteriorating the manifestation of leprosy infection. All clinical spectrum of leprosy was found in HIV infection patients without predomination of lepromatous type. Responses to leprosy Multi-Drug Therapy (MDT) regimen were also found similar between leprosy patients with or without HIV.Conclusion: It is recommended to treat co-infective patients both with leprosy MDT and antiretroviral therapy. Manifestation of leprosy as a part of immune reconstitution syndrome need more attention and investigation.Keywords: HIV infection, leprosy, interaction
Bacterial vaginosis as a risk factor of preterm premature rupture of membrane (PPROM) Wiraguna, Aanak Agung Gde Putra; Rusyati, Luh Made Mas; Vijayamurthy, I Dewa Ayu Vanessa
Bali Dermatology and Venereology Journal Vol 1, No 2 (2018)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (675.975 KB) | DOI: 10.15562/bdv.v1i2.13

Abstract

Introduction: The pathogenesis of PPROM is complex and not fully understood. Recent studies showed that such role of genital tract infection as bacterial vaginosis in the pathogenesis of PPROM turned out to be present. They produce lipase enzymes in which they can form compounds with the fibrous tissue of amniotic membrane resulting in increased risk of rupture of the membrane.Objective This study aims to prove that bacterial vaginosis is a risk factor for preterm premature rupture of membrane.Material and methods: This research used case control method. Sampling was using the consecutive sampling method and had fulfilled inclusion and exclusion criteria with age-based matching, then vaginal swab sampling was conducted, painted with gram staining in the Dermalotogy and Venereology Laboratory of Sanglah Hospital, and Nugent score.Result: Total of 76 pregnant women with 24-36 weeks of gestation were investigated, 38 mothers with PPROM and 38 mothers with normal pregnancy. Average score of Nugent at preterm PROM was 7.18 and in normal pregnancy was 2.37. Bacterial vaginosis risking for PPROM 7 times (OR= 7.0, 95% CI= 1.21-17.68, p= 0.001).Conclusion: Bacterial vaginosis as a risk factor for the occurrence of PPROM.
PREVALENCE AND QUALITY OF LIFE OF PEMPHIGUS PATIENTS AT SANGLAH GENERAL HOSPITAL BALI-INDONESIA Wardhana, and, M.; Rusyati, L. M.
BALI MEDICAL JOURNAL Volume 2 Number 1, January-April 2013
Publisher : BALI MEDICAL JOURNAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (277.035 KB)

Abstract

Objectives: Pemphigus vulgaris (PV) is an autoimmune-blistering disease of the skin and mucous membranes caused by auto-antibodies against desmoglein-3 (Dsg-3) on the keratinocyte cell surface of squamous stratified epithelia. Pemphigus is a life-threatening autoimmune bullous disease resulting in the widespread denudation of skin and mucous membrane and severe impact of quality of life. The purpose of this study was to evaluate retrospectively the prevalence of pemphigus and to elucidate the clinical variants, clinical course, prognosis and quality of life (QOL) of pemphigus patients after discharge from hospitalized. Method: Observational non analytical retrospective study was conducted by observation of the medical records of all the newly registered patients with pemphigus at Sanglah General Hospital in Bali-Indonesia during the period of January 1995 and December 2002, and analyzed with regard to personal statistic, history of the diseases including onset, site of affected, symptoms, clinical diagnosis, severity, associated illness, therapy, and quality of life based on the Finlay’s methods. Results: During the 8-year periods studies, 33 pemphigus patients were admitted, represented 5.8 % of  all patients admitted in our in-patient ward during the periods. Our patients consist of female 20 patients (60.6 %) and male 13 patients (39.4 %). The most common of clinical type was pemphigus vulgaris 26 patients (78.78 %), followed by pemphigus foleaceous and pemphigus vegetans. Six patients (18.18 %) of 16 severe patients with severe condition at the clinical course of the diseases was death during the course of hospitalized. A number of 2 patients, in this study were observed with severe impact of quality of life. Conclusion: Our finding showed that pemphigus vulgaris is common type of our cases has a relatively high prevalence our hospital (5.8 %), and relatively high death rate (18.18 %). In our study, systemic corticosteroid was still applied until present for life saving drug for Pemphigus.
Histiositosis sel langerhans pada seorang anak Luciana, Luciana; Rusyati, Luh Mas
Medicina Vol 47 No 2 (2016): Mei 2016
Publisher : Medicina

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (533.956 KB)

Abstract

Histiositosis sel Langerhans (HSL) adalah penyakit akibat proliferasi sel Langerhans yang terjadi di berbagai organ dan jaringan. Penyakit HSL memiliki manifestasi klinis bervariasi dari lesi tunggal hingga multisistem. Manifestasi kulit sering menunjukkan gambaran tidak khas, menyerupai banyak penyakit kulit lain dan sering dianggap sebagai penyakit tidak berbahaya sehingga tidak mendapatkan pengobatan tepat. Seorang anak lelaki 2 tahun 4 bulan dirawat dengan keluhan bintik-bintik merah di seluruh tubuh dan bercak merah gelap pada telapak tangan dan telapak kaki. Kuku tampak kehitaman. Pasien juga menderita penyakit hati kronis, hipertensi portal, tuberkulosis paru, serta malnutrisi marasmus-kwasiorkor. Diagnosis ditegakkan berdasarkan anamnesis, pemeriksaan fisis dan pemeriksaan penunjang biopsi kulit yang sesuai dengan HSL. Pasien diberikan monokemoterapi vinblastin dan hari ke-15 pasien meninggal karena disseminated intravascular coagulation dan kegagalan multiorgan. Langerhans cell histiocytosis (LCH) is a disease caused by the proliferation of Langerhans cell in various organs and tissues. Langerhans cell histiocytosis disease has various clinical manifestation from single lesions to multisystem. Skin manifestations is not pathognomonic, resembling many other skin disease and considered non-threatening, thus delaying access to appropriate treatment. A 2- year and 4 month old boy presented with red spots all over the body and dark red patches on the palms, soles, and blackish nails. The patient was also suffered from chronic liver disease, portal hypertension, pulmonary tuberculosis, as well as marasmic kwasiorkhor. Diagnosis was based on history, physical examination, and skin biopsy. The patient was given vinblastine monochemotherapy, and on day 15, the patient died due to disseminated intravascular coagulation and multiple organ failure.
Selection of topical corticosteroids in children atopic dermatitis Stephanie, Aurelia; Sudarsa, Prima Sanjiwani Saraswati; Rusyati, Luh Mas
Bali Dermatology and Venereology Journal Vol 2, No 2 (2019)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/bdv.v2i2.30

Abstract

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease that typically starts in childhood with classic symptoms of dry and itchy skin that occurs continuously and recurrences and even causes sleep disorders and skin that is susceptible to infection. AD sufferers often have atopic comorbidities such as asthma and allergic rhinitis in themselves and their families. The effects of this itching cycle result in growth disturbance and decreased quality of life for AD patients and their parents. Moderate and severe AD have an impact on parents, the stress in medication, and care, which takes up time and money. Atopic dermatitis is due to damage to the skin barrier, so the principle of management is to improve the skin barrier so that the inflammatory process can be avoided. The course of AD is chronic and relapsing; generally, patients come for treatment with an acute phase that sometimes requires topical corticosteroids. However, topical corticosteroids (TC) are used only to treat the acute phase for a short period. After the acute lesions have subsided, corticosteroids can be stopped immediately to prevent side effects and continue with daily skincare.Conclusion: Topical corticosteroids are first-line therapy in the acute phase. The choice of TC is based on age, body location, dosage, and severity of AD. If the acute lesion has subsided, then corticosteroids can be stopped and substituted with other antipruritic therapy and moisturizer.
Focus on the dabrafenib, vemurafenib, and trametinib in clinical outcome of melanoma: a systematic review and meta-analysis Widya Anjani, Ida Ayu; Indrakusuma, Anak Agung Bagus Putra; Arim Sadeva, I Gede Krisna; Wulandari, Putri Ayu; Rusyati, Luh Made Mas; Sudarsa, Prima Sanjiwani Saraswati; Supadmanaba, I Gede Putu; Wihandani, Desak Made
Bali Dermatology and Venereology Journal Vol 3, No 2 (2020)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/bdv.v3i2.38

Abstract

Background: Melanoma is the most serious lethal skin cancer, affects the melanin producer cells (melanocytes). Surgery is the most common treatment, whereas for the advance stage the development of a treatment is recommended. BRAF (Dabrafenib and Vemurafenib) inhibitor or MEK inhibitor (Trametinib) is used as the most frequently targeted therapy of melanoma due to more than 80% patient with positive BRAF mutation. In this review, those treatments will be investigated systematically to identify their clinical outcome.Method: This systematic literature review (SLR) was performed from Cochrane, Science Direct, Google Scholar, and Pubmed. Cochrane Risk-of-Bias Tool RoB2 is used to assess RCT studies and New-castle Ottawa Scale Assessment to assess cohort studies by 3 different assessors. Data analysis was carried out by using Review Manager (RevMan 5.4). Heterogenicity test was assessed by I2  and Chi2 statisticResult: There are 20 studies used in this article (13 RCT and 7 cohorts). The overall survival (OS) and progression-free survival (PFS) of study that using targeted therapy (vemurafenib, trametinib, or dabrafenib) compare other therapies (chemotherapy, immunotherapy,etc) showed risk ratio (RR) was 1.12 (95%CI 1.07,1.17;  I2=100%; p<0,00001). The OS and PFS with monotherapy compare of vemurafenib, trametinib, or dabrafenib with combination therapy showed RR was 1.09 (95%CI.06,1.13;I2=99%; p<0,00001). Conclusion: BRAF and MEK targeted therapy has a good prognosis for a patient with a positive BRAF gene mutation and could be combined with other therapy for a better clinical outcome rather than monotherapy.Keyword: melanoma, dabrafenib, vemurafenib, and trametinib
Negative correlation between interleukin-2 (IL-2) serum with bacterial index in leprosy Putri, Patricia Dian; Rusyati, Luh Made Mas; Adiguna, Made Swastika
Bali Dermatology and Venereology Journal Vol 3, No 1 (2020)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/bdv.v3i1.34

Abstract

Background: Leprosy is strongly influenced by the host immunity response. One of the cytokines that play a role in cellular immunity is IL-2. IL-2 will stimulate macrophages to activate phagocytosis and form granulomas, and this occurs in the tuberculoid type of leprosy.Objective: Aim of this study was to verify the IL-2 serum levels are negatively correlated or not with bacterial index in leprosy.Methods: This study was a cross-sectional observational analytic study involving 50 leprosy subjects (41 MB and 9 PB types). Study was conducted at Dermatolovenerology Polyclinic of Sanglah General Hospital from December 2019 to March 2020. Sample was taken using a consecutive sampling method. IL-2 serum levels were measured by ELISA. Result: The mean of IL-2 serum in PB was 75.53±10.32 pg/mL and in MB was 37.59±17.13 pg/mL. Strong negative correlation (r= -0.67; p<0.001) between serum IL-2 levels with bacterial index (CI 95%= 25.96–49.93; p<0.001) was found. Every 1 pg/mL increase in IL-2 serum levels will be accompanied by a decrease in the bacterial index of 0.039 and vice versa. Determinant coefficient shows that 42.2% of bacterial index affected by the IL-2 serum levels. Low IL-2 serum levels were the risk factor of high bacterial index 2.8 times (PR= 2.8; CI 95%= 1.444–5.519; p<0.001).Conclusion: IL-2 serum levels were found to be higher in PB than MB. There was a negative correlation between IL-2 serum levels with bacterial index. Low IL-2 serum levels were the risk factor of a high bacterial index in leprosy patients.
COVID-19 and ophthalmic herpes zoster co-infection in immunocompetent patient Sissy, Sissy; Santoso, Adeline; Gotama, Dewi; Rusyati, Luh Made Mas
Bali Dermatology and Venereology Journal Vol 4, No 1 (2021)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/bdv.v4i1.45

Abstract

Background: Varicella-zoster virus (VZV) is a virus of human neurotropic that remains within ganglionic neurons in a latent state after the primary infection throughout the entire neuroaxis.Case: A male patient, 32 years old Javanese, consulted from the pulmonary division with complaints of vesicular eruption in the facial area on September 27, 2020. The patient was diagnosed with ophthalmic herpes zoster and a mild COVID-19 infection since 2 days ago and was hospitalized. Management in patients was acyclovir, methylprednisolone, with analgesics and vitamins. COVID-19 as co-infection and other viruses has been known, but infrequently affect the respiratory tract.Conclusion: Herpes zoster patient should ruled out the COVID-19 and maximize the precaution for personal safety equipment until the SARS-CoV-2 is excluded.
The efficacy of fractional erbium:YAG laser (2940 nm) compared to Microneedling of topical amniotic membrane stem cell conditioned medium (AMSC-CM) for photoaging Cita Rosita Sigit Prakoeswa; Riyana Noor Oktaviyanti; Wisnu Triadi Nugroho; Febrina D Pratiwi; Luh Mas Rusyati; I G A A Praharsini; I G A A Elis Indira
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14694

Abstract

Background: Photoaging is a complex biologic process that affects various layers of the skin. Amnioticmembrane stem cell conditioned medium (AMSC-CM) that contain growth factors and have capability toimprove clinical picture of photoaged skin. Microneedling and laser devices are transdermal drug deliverymethods which shows promising results to improve photoaging .Objective: To investigate the efficacy of topical AMSC-CM after YAG erbium fractional laser compare tomicroneedling in photoaging.Method :A clinical study, 60 adult women with photoaging. Randomized into two groups A 30 womenreceived AMSC-CM after fractional erbium:YAG laser (2940nm) and group B 30 woman received AMSCCM after microneedling. Both groups received the treatment 3 times with 2 weeks interval. The improvementof pore, wrinkle, and UV spot as was evaluate before, after and post treatment using computer-stimulatedphotograph skin analyzer.Result: The evaluation of pore and UV spot showed greater improvement in the group of AMSC-CM withfractional erbium:YAG laser compare to AMSC-CM with microneedling group (pore p:0,00 and UV spotp:0,00). There was no significant different (p 0.43) of wrinkle improvement between both groups.Conclusion: The combination of AMSC-CM and fractional erbium:YAG laser have better efficacy in theimprovement in photoaged skins.
Co-Authors A.A.N.B. Adhitya Wirakusuma Aanak Agung Gde Putra Wiraguna Adeline Santoso Agnes Sri Siswati Agung Bagus S. Satyarsa Anak Agung Bagus Putra Indrakusuma Anak Agung Gde Putra Wiraguna Andrew Wicaksono Angela Sandi Tagaroi Rahasia Anum, Qaira Arim Sadeva, I Gede Krisna Aurelia Stephanie Aurelia Stephanie Aurelia Stephanie Bagus Haryo Kusumaputra Cita Rosita Sigit Prakoeswa Darmaputra, I Gusti Nyoman Desak Made Wihandani Desak Nyoman Trisepti Utami Dewa Made Rendy Sanjaya Dewi Gotama Dhelya Widasmara Dian Galih SIliwangi Edward Wijaya, Edward Elice Wijaya Elice Wijaya Febrina D Pratiwi Fifa Argentina Firly Clarissa Suyanto Gde Ngurah Arya Ariwangsa Gede Made Cahya Trisna Pratama Gede Mahadika Pradipta Atmaja GK Darmaputra Gotama, Dewi Haikal Hamas Putra Iqra Handelia Phinari Herman Saputra I Dewa Ayu Vanessa Vijayamurthy I Dewa Ayu Vanessa Vijayamurthy I Dewa Made Rendy Sanjaya I G. P. Supadmanaba I Gede Agus Bhakti Suputra I Gede Krisna Arim Sadeva I Gede Raditya Narayana I Gede Wahyu Toya Pratama I Gusti Amanda Jaya I Gusti Ayu Agung Dwi Karmila I Gusti Ayu Agung Elis Indira I Gusti Ayu Agung Praharsini I Gusti Ayu Agung Praharsisni I Gusti Ayu Tika Indriani I Gusti Ketut Darmada I Gusti Ketut Darmada I Gusti Nyoman Sri Wiryawan I Komang Arimbawa I Made Oka Adnyana I Made Swastika I Pt Agus Suryantara P I Putu Arie Sasmita I Putu Eka Widyadharma I Putu Gilang Iswara Wijaya I.G.A. Karmila I.G.K Darmada I.G.K. Darmada Ida Ayu Diah Purnama Sari Ida Ayu Uttari Priyadarshini Ida Ayu Widya Anjani IGK Darmada Indira, I Gusti Ayu Agung Elis Indra Teguh Wiryo Indra Teguh Wiryo Indrakusuma, Anak Agung Bagus Putra Indry Salonika Sutiawan Intizam, Marwa Humaira Jason Jonathan Jayawarsa, A.A. Ketut Jusuf, Pierre Joshua Kadek Ayu Rima Mahadewi Kadek Yuda Sujana Ketut Kwartantaya Winaya Ketut Wida Komalasari Komang Ayu Kristiana Dewi K Laksmi, I Gusti Ayu Agung Mini Limanda, Claudia Felicia Lisa Alverina Lubis, Ramona Sari Luciana Luciana M. Yulianto Listiawan Made Hermina Laksmi Made Martina Windari Made Swastika Adiguna Made Wardhana Mamuaja, Enricco Hendra Mario Korwa Martima W Medhi Denisa Alinda, Medhi Denisa Muchtar, Vitayani Mulianto, Nur Rachmat Nandya Dwizella Nevristia Pratama Ni Kadek Setyawati, Ni Kadek Ni Luh Putu Ratih Vibriyanti Karna Ni Made Dwi Puspawati Ni Made Linawati Nyoman Raditya Adiprayoga Nyoman Suryawati Patricia Dian Putri Praharsini, I Gusti Agung Prima Saraswati Sanjiwani Sudarsa Prima Sudarsa Prima Sudarsa Prima Sudarsa Primasari, Putu Yunita Puspawati . Putri Ayu Wulandari Putri Ayu Wulandari, Putri Ayu Putri, Patricia Dian Putri, Putu Winna Deyanti Putu Ayu Saraswati Putu Diah Pratiwi Putu Gde Hari Wangsa Putu Raisha Vishkariana Dewi Ratih Vebrianti Ratih Vibriyanti Karna Regitta Indira Agusni Renni Yuniati Riyana Noor Oktaviyanti Sadeli, Marrietta Sugiarti Santoso, Adeline Saravanan Krishnan Sari, Luh Gede Melia Puspita Sissy Sissy Sissy, Sissy Sofyan Faridi Sri L. Menaldi Stephanie, Aurelia Sudarsa, Prima Suharmono Hadi Suryawati . Sutiajaya, Nikita Lestari Sutiawan, Indry Salonika Tanujaya, Monica Aprilia Thiodorus, Robert Tiara Evangelista Trisna Yuliharti Tersinanda Vijayamurthy, I Dewa Ayu Vanessa Widya Anjani, Ida Ayu Winaya, Ketut Kwartantaya Wiryo, Indra Teguh Wisnu Triadi Nugroho Yara Egyptha Saraswati