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All Journal journal of internal medicine E-Jurnal Medika Udayana ISM (Intisari Sains Medis) : Jurnal Kedokteran Bali Dermatology and Venereology Journal Essential: Essence of Scientific Medical Journal Bali Dermatology Venereology and Aesthetic Journal
Made Swastika Adiguna
Dermatology And Venereology Departement, Faculty Of Medicine, Universitas Udayana, Sanglah General Hospital Denpasar, Bali, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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High plasma dopamine level as a risk factor for atopic dermatitis Adiguna, Made Swastika; Wardhana, Made; Limbara, Ermon Naftali
Bali Dermatology and Venereology Journal Vol 2, No 1 (2019)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (216.169 KB) | DOI: 10.15562/bdv.v2i1.15

Abstract

Background: Dopamine is responsible for inflammatory response and plays a role in the skin immune system by modulating T-cells, dendritic cells, and keratinocytes which increases skin inflammatory response in atopic dermatitis (AD). Elevation of dopamine level will affect IL-6, IL-8, IL-23, Th-17, and TNF-α, which promotes keratinocyte proliferation and differentiation, infiltration of inflammatory cells, angiogenesis, vasodilation, and skin barrier disruption on AD.Objective: This study aimed to establish whether the increase of plasma dopamine level contributes to a risk factor for AD occurrence.Methods: This is a matched-pair case-control observational analytical study which involves patients with AD and without AD as control. Samples were taken using a consecutive sampling method which fulfilled inclusion and exclusion criteria, matched for gender and age. Plasma dopamine level was measured from venous blood and processed using enzyme-linked immunosorbent assay (ELISA) method. The collected data were then analysed using SPSS version 20.0 with Pearson chi-square test for the odds ratio.Results: A total of 30 samples with AD (case group) and 30 samples without AD (control group) involved in this study. This study proves that plasma dopamine levels in the case group were significantly higher than the control group (p<0.05). Odds ratio for plasma dopamine was 42.2 (95%CI: 9.5-187.2, p < 0.001).Conclusion: This study concludes that high plasma dopamine level is a risk factor for AD.
Positive correlation between psoriasis vulgaris severity degree with HbA1C level Adiguna, Made Swastika; Wardhana, Made; Rahardjo, Fresa Nathania
Bali Dermatology and Venereology Journal Vol 1, No 2 (2018)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (348.961 KB) | DOI: 10.15562/bdv.v1i2.11

Abstract

Introduction: Psoriasis is a skin abnormality based on chronic inflammation immune mediated. Inflammatory mediator roles (Th-1, TNF-α, IL-6,IL-7, IL-8, IL-17, and IL-23) in its pathogenesis proven to inhibit insulin receptor and glucose uptake from fat tissue and causing insulin resistance, then blood glucose level increased. Mean blood glucose level within 3 months can be represented by HbA1c (glycosylated haemoglobin) level. HbA1c is a bond between glucose and hemoglobin.           Objective: The aim of this study is to understanding correlation between psoriasis vulgaris severity degree with HbA1c.Material and methods: This study is using cross sectional method. HbA1c level examination done by drawing venous blood, then analyzed with chromatography method. Samples were selected by using inclusion and exclusion criteria and consecutive sampling method.Result: Study result shows subject consist of total 51 subjects consists of 33 subjects with psoriasis vulgaris (22 males and 11 females with youngest age of 15 and oldest age of 65 years old), and 18 subjects without psoriasis vulgaris. Psoriasis vulgaris severity degree measured with Psoriasis Area Severity Index (PASI), then grouped to 3 categories: mild PASI score <6, moderate PASI score  6 – 12, and severe PASI score> 12. Mostly  (15 subjects) including mild category. HbA1c level on this study subjects resulted minimum level of 4.6%, maximum 12.1 %, and median 5.4%.  Based on Perkeni consensus, normal HbA1c level is <5,7%, prediabetes 5,7-6,4%, and diabetes >6,5%. HbA1c level of psoriasis vulgaris subjects are higher than non psoriasis vulgaris subjects significantly (p=0,019). Psoriasis vulgaris causing increase of HbA1c level with Prevalence Ratio (PR) 6,55. Thus, Psoriasis vulgaris subjects have increased risk 6,5 times to increase HbA1c level compared with non psoriasis vulgaris subjects. Correlation between severity degree and HbA1c level found in positive course significantly with moderate strength of correlation (Spearman correlation; r = 0.580, p<0,001).Conclusion: HbA1c level on psoriasis vulgaris subjects are higher than non psoriasis vulgaris, and psoriasis vulgaris severity degree positively correlated with HbA1c increasing level. Every increase of  psoriasis vulgaris severity degree will cause increase level of  HbA1c.
Low plasma level of insulin-like growth factor-I (IGF-I) is a risk factor for multibacillary type of leprosy Rusyati, Luh Mas; Adiguna, Made Swastika; Wiryo, Indra Teguh
Bali Dermatology and Venereology Journal Vol 1, No 2 (2018)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (99.604 KB) | DOI: 10.15562/bdv.v1i2.12

Abstract

Introduction: Leprosy is one of infectious diseases with complex issues. Previous study showed poverty, malnutrition, lack of proper food and nutrient intake, as well as low income. Recently, many studies reported insulin-like growth factor-I (IGF-I) as excellent nutrient marker.Objective: This study aims to prove that low plasma level of insulin-like growth factor-I is a risk factor for multibacillary type of leprosy. Material and methods: This case-control study design involved 38 patients with leprosy subjects as cases and 38 control subjects. The sample collection is done by consecutive sampling and has fulfilled the inclusion and exclusion criteria which matched by age and gender in Dermatology and Venereology Outpatient clinic of Sanglah General Hosptital. The collected data was analyzed using SPSS version 23.0 with Pearson Chi square test to obtain Odds Ratio. Results: This study showed that IGF-I plasma levels in the case group were significantly lower than the control group (p<0.05) with Odds ratio for IGF-I plasma 34.61 (95% CI= 7.17-167.01, p<0.001)Conclusion: Low plasma level of insulin-like growth factor-I is a risk factor for multibacillary type of leprosy.
Positive correlation of psoriasis vulgaris severity and HOMA-IR Wardhana, Made; Adiguna, Made Swastika; Nareswari, Putu Ayu Diah
Bali Dermatology and Venereology Journal Vol 2, No 1 (2019)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (15.671 KB) | DOI: 10.15562/bdv.v2i1.18

Abstract

Background: Psoriasis vulgaris is a chronic inflammatory skin disease that its aetiology is still not completely known. A chronic inflammation in psoriasis can cause organ dysfunctions. Elevation of proinflammatory cytokines gives rise to insulin resistance by inhibiting insulin and glucose transport mechanism signals. Insulin resistance is the underlying pathogenesis of metabolic syndrome.Objective: This study aimed to undestand any correlation in the severity of psoriasis vulgaris with HOMA-IR.Methods: A cross sectional research involving 35 subjects with psoriasis vulgaris and 15 subjects without who met the selection criteria. HOMA-IR is a formula used to measure insulin resistance which calculates the fasting insulin value in μU/ml x fasting glucose in mg/DL/405 taken from the blood veins of subjects. PASI score was used to determine psoriasis vulgaris severity.Results: This study shows that the HOMA-IR median value was higher in psoriasis subject than the subjects without psoriasis (p<0.05). The correlaton analysis shows a moderate positive correlation between psoriasis vulgaris severity and HOMA-IR (r= 0.427; p<0.05). The prevalence ratio was 8.57, which means psoriasis vulgaris subjects were 8.57 times more likely to have HOMA-IR compared to those without psoriasis vulgaris (p<0.05; 95%CI: 1.26-58.1).Conclusion: This study concludes that there is a moderate positive correlation between severity of psoriasis vulgaris and HOMA-IR values.
SEORANG WANITA DENGAN URTIKARIA KRONIK IDIOPATIK Suryana, Ketut; Suastika Adiguna, Made
journal of internal medicine Vol. 7, No. 2 Mei 2006
Publisher : journal of internal medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (152.01 KB)

Abstract

Urticaria is characterized by red edematous plaques surrounded by a clear or red halo. The lesions are round or oval andmay become polycyclic when confluent. They usually multiple and vary from 1 mm to several centimeters in diameter. They canoccur at any site of the body and are typically associated with itching and sometimes burning. Skin returns to its normalappearances usually within 1-24 hours. Urticaria is sometimes accompanied by angioedema, in which the edematous processextends into the deep dermis and / or subcutaneous tissues. While patient with urticaria usually have symptoms confined to theskin they may have concomitant systemic manifestations. Urticaria is termed acute when episode less than 6 weeks, it’s termedchronic when episode persist longer. Chronic urticaria / angioedema, the syndrome last and average of 3-5 years, with 20%patients still symptomatic at 40 years. The syndrome is frustrating to patient and clinician alike in death a search for an exogenouscause is futile in the majority of patients. However in recent year its has been demonstrated that many patients involved idiopathicchronic urticaria (80% of the chronic type urticaria). The incidence of idiopathic chronic urticaria was 3% population. Thediagnosis, there is no the specific approach. Mostly based on clinical history and several laboratory procedure and in certaincondition need skin biopsy. The management; allergen avoidance, medicamentosa symptomatically. The first line; non sedatingsecond-generation AH-1 and in a several case add by antihistamine AH-2. in severe case sometimes need the corticosteroids oranother immunosuppressive.
Negative correlation between interleukin-2 (IL-2) serum with bacterial index in leprosy Putri, Patricia Dian; Rusyati, Luh Made Mas; Adiguna, Made Swastika
Bali Dermatology and Venereology Journal Vol 3, No 1 (2020)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/bdv.v3i1.34

Abstract

Background: Leprosy is strongly influenced by the host immunity response. One of the cytokines that play a role in cellular immunity is IL-2. IL-2 will stimulate macrophages to activate phagocytosis and form granulomas, and this occurs in the tuberculoid type of leprosy.Objective: Aim of this study was to verify the IL-2 serum levels are negatively correlated or not with bacterial index in leprosy.Methods: This study was a cross-sectional observational analytic study involving 50 leprosy subjects (41 MB and 9 PB types). Study was conducted at Dermatolovenerology Polyclinic of Sanglah General Hospital from December 2019 to March 2020. Sample was taken using a consecutive sampling method. IL-2 serum levels were measured by ELISA. Result: The mean of IL-2 serum in PB was 75.53±10.32 pg/mL and in MB was 37.59±17.13 pg/mL. Strong negative correlation (r= -0.67; p<0.001) between serum IL-2 levels with bacterial index (CI 95%= 25.96–49.93; p<0.001) was found. Every 1 pg/mL increase in IL-2 serum levels will be accompanied by a decrease in the bacterial index of 0.039 and vice versa. Determinant coefficient shows that 42.2% of bacterial index affected by the IL-2 serum levels. Low IL-2 serum levels were the risk factor of high bacterial index 2.8 times (PR= 2.8; CI 95%= 1.444–5.519; p<0.001).Conclusion: IL-2 serum levels were found to be higher in PB than MB. There was a negative correlation between IL-2 serum levels with bacterial index. Low IL-2 serum levels were the risk factor of a high bacterial index in leprosy patients.
PENGARUH PENYULUHAN MENGENAI KESEHATAN ORGAN REPRODUKSI WANITA TERHADAP TINGKAT PENGETAHUAN MENGENAI KEPUTIHAN PADA REMAJA PUTRI SMKN 3 DENPASAR Jason Jonathan; Made Swastika Adiguna; Nyoman Suryawati; Luh Made Mas Rusyati
E-Jurnal Medika Udayana Vol 10 No 4 (2021): Vol 10 No 04(2021): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2021.V10.i4.P13

Abstract

ABSTRAK Potensi wanita mengalami keputihan di Indonesia mencapai 90% yang disebabkan oleh iklim Indonesia. Indonesia yang beriklim tropis menyebabkan jamur berkembang dengan mudah sehingga banyak terjadi kasus keputihan. Hal ini mendukung pentingnya kebutuhan edukasi kesehatan reproduksi untuk lebih ditingkatkan. Informasi dan edukasi kesehatan reproduksi yang masih kurang dan sulitnya menjangkau pelayanan kesehatan reproduksi juga turut mendukung pentingnya kebutuhan remaja terhadap peningkatan pelayanan kesehatan reproduksi. Tujuan dari penelitiani inii adalahi untuki mencarii adanyai pengaruhi penyuluhani kesehatani mengenaii organi reproduksii wanitai terhadapi tingkati pengetahuani mengenaii keputihani padai remajai putrii SMKNi 3i Denpasar.i Jenisi penelitiani inii adalahi penelitiani prei–ieksperimentali dani menggunakani onei groupi pretesti –i postesti designi dani pemberiani intervensii penyuluhani kepadai siswii kelasi XIIi SMKNi 3i Denpasari padai Oktoberi 2019.i Tekniki pengumpulani sampeli dengani metodei Stratifiedi Proportionalei Randomi Samplingi dengani sampeli sebanyaki 74i siswi.i Analisisi datai dilakukani dengani programi SPSSi dani ujii Wilcoxon.i Karakteristiki respondeni padai penelitiani inii berdasarkani umuri adalahi padai rentangi umuri 16i sampaii 19i tahun.i Kejadiani terjadinyai penurunani hasili pretesti dani postesti sebanyaki 8i kejadiani darii totali 74i kejadiani dengani meani ranki 23,5.i Sedangkani terjadinyai kenaikani hasili pretesti dani postesti sebanyaki 57i kejadiani darii totali 74i kejadiani dengani nilai reratai 34,33.i Kejadiani tidaki mengalamii penuruani maupuni kenaikani hasili terjadii sebanyaki 9i kejadiani darii totali 74i kejadian.i Setelahi datai dianalisisi dengani membandingkani tingkati pengetahuani sebelumi dani setelahi diberikani penyuluhani mengenaii kesehatani reproduksii dani menggunakani tingkati kesalahani (?)i =i 0,05,i didapatkani nilaii signifikansii 0,000. Nilai signifikansi ini lebih kecil dari 0,05 sehingga Ha dapat diterima dan didapatkan hasil bahwa ada pengaruh penyuluhan mengenai kesehatan organ reproduksi wanita terhadap tingkat pengetahuan remaja putri SMKN 3 Denpasar. Kata kunci: Keputihan, Remaja, Kesehatan Reproduksi
Prevalensi dan karakteristik infeksi menular seksual di Klinik Anggrek UPT Ubud II pada bulan Januari - Desember 2016 Ni Putu Candra Nirmalasari P; Md Swastika Adiguna; Ni Made Dwi Puspawati
E-Jurnal Medika Udayana Vol 7 No 4 (2018): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (254.169 KB)

Abstract

Sexually Transmitted Infections (STI) is one of the world’s major health problems. Bali, and in particular the town of ubud is a world famous tourist destination and often visited by foreigners. This makes Ubud very vulnerable to the spread of STIs. The purpose of this study was to determine the prevalence and characteristics of STI cases based on age, gender and risk factors at the Anggrek clinic UPT Ubud II from January to December 2016. This research is a descriptive research with secondary data gathered from the medical record. Sample of this research is medical record of STI patient who came to Anggrek clinic UPT Ubud II in the period of 1 January - 31 December 2016 with amount of 273 samples. Secondary data are further processed statistically by using statistical software.The results of the study showed the most frequent STIs were HIV, there were 134 cases (49.1%), followed by Syphilis with 69 cases (25.3%), Gonorrhea with 61 cases (22.3%) and Condyloma Akuminata with 9 cases (3.3%). Men had the higher incidence of STI with 251 cases (91.9%) whereas in women there were only 22 cases (8.1%). The highest STI population was in the age group of 25-49 years where there were 166 cases (60.8%). The highest risk factor for Condyloma acuminata, gonorrhea and syphilis was 79 people (56.8%), in HIV the highest risk factor was homosexual (MSM) of 112 cases (83.6%). It can be concluded that the characteristic of STI patients found is HIV as the most frequent type of STI, where the incidence of STIs is more common in males, in the 25-49 age group with homosexual (MSM) risk factors. Keywords: STI, Ubud, Characteristics
PROPORSI DAN KARAKTERISTIK AKNE VULGARIS PADA MAHASISWA PROGRAM STUDI SARJANA KEDOKTERAN DAN PROFESI DOKTER FAKULTAS KEDOKTERAN UNIVERSITAS UDAYANA TAHUN 2019 Joanne Roxanne; I Gusti Ayu Agung Elis Indira; Made Swastika Adiguna; I Gusti Ayu Agung Dwi Karmila
E-Jurnal Medika Udayana Vol 10 No 4 (2021): Vol 10 No 04(2021): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2021.V10.i4.P15

Abstract

ABSTRAK Latar Belakang: Akne vulgaris (AV) merupakan penyakit yang umum terjadi pada remaja dan merupakan penyakit multifaktorial. Tujuan: Penelitian ini bertujuan untuk mengetahui proporsi dan karakteristik (jenis, distribusi, dan klasifikasi tingkat keparahan) serta beberapa faktor pencetus yang menyertai kejadian AV pada mahasiswa kedokteran yang sebagian besar dalam usia remaja Metode: Penelitian ini merupakan penelitian potong lintang deskriptif. Pengambilan data dilakukan dengan menggunakan formulir pengambilan data dilanjutkan dengan pemeriksaan lesi oleh peneliti. Hasil: Terdapat 87 (70,2%) dari 124 peserta penelitian yang terdiagnosis AV pada Mahasiswa Program Studi Sarjana Kedokteran dan Pendidikan Dokter Fakultas Kedokteran Universitas Udayana tahun 2019. Laki-laki lebih banyak mengalami AV (51,7%) dibandingkan perempuan (48,7%). Jenis lesi yang paling banyak ditemukan adalah komedo dengan tingkat klasifikasi ringan dan distribusi lesi paling banyak pada wajah. Komplikasi yang paling banyak terjadi adalah hiperpigmentasi. Diagnosis AV lebih banyak ditegakan pada subjek yang tidak memiliki riwayat keluarga, jarang membersihkan wajah (<3 kali sehari). Tercatat penggunaan masker bahan alami dalam penanganan AV yaitu spirulina, tomat, madu dan teh hijau Kata Kunci: Akne vulgaris, Proporsi, Karakteristik, Faktor Pencetus
HUBUNGAN TINGKAT PENGETAHUAN DAN SIKAP MENGENAI PAPARAN SINAR MATAHARI DAN KANKER KULIT PADA MAHASISWA KELAUTAN DAN PERIKANAN UNIVERSITAS UDAYANA, BALI Sang Ayu Arta Suryantari; agung bagus sista Satyarsa; I Gusti Ayu Tika Indriani; Prima Saraswati Sudarsa; Luh Mas Rusyati; Made Swastika Adiguna
Essence of Scientific Medical Journal Vol 17 No 1 (2019): Volume 17 No. 1 (Januari-Juni 2019) ESSENTIAL: Essence Of Scientific Medical Jou
Publisher : Kelompok Ilmiah Hippocrates Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/ESTL.2019.v17.i01.p07

Abstract

Pendahuluan: Mahasiswa yang sering melakukan aktivitas belajar di luar ruangan termasuk kelompok yang berisiko mengalami kanker kulit. Hal tersebut disebabkan karena mereka sering terpapar sinar matahari langsung dengan intensitas yang tinggi. Penelitian ini bertujuan untuk mengetahui hubungan antara tingkat pengetahuan dan sikap mahasiswa Fakultas Kelautan dan Perikanan Universitas Udayana terhadap paparan sinar matahari dan kanker kulit. Metode: Penelitian yang digunakan yaitu analitik cross-sectional yang dilaksanakan pada tanggal 18 Juni – 20 Juni 2018 di Fakultas Kelautan dan Perikanan Universitas Udayana, Bali. Data karakteristik sosiodemografi, tingkat pengetahuan dan sikap diperoleh menggunakan kuesioner yang tervalidasi sebelumnya. Data kemudian dianalisis menggunakan SPSS. Hasil: Terdapat 119 orang responden yang terlibat dalam penelitian ini dengan median usia 20 (16-24) tahun. Sebagian besar responden adalah perempuan (64,7%). Sebanyak 108 orang (90,8%) memiliki pengetahuan yang baik dan sebanyak 60 orang (50,4) memiliki sikap positif. Pembahasan: Terdapat hubungan yang bermakna antara jenis kelamin dan sikap (p=0,047) serta antara tingkat pengetahuan dan sikap (p=0,000). Simpulan: Dapat disimpulkan bahwa responden yang memiliki pengetahuan yang baik dan sikap positif cukup tinggi. Terdapat hubungan yang bermakna antara tingkat pengetahuan dan sikap mengenai paparan sinar matahari dan kanker kulit.
Co-Authors Agung Bagus S. Satyarsa Ermon Naftali Limbara Ermon Naftali Limbara Fresa Nathania Rahardjo Fresa Nathania Rahardjo I Gusti Ayu Agung Dwi Karmila I Gusti Ayu Agung Elis Indira I Gusti Ayu Tika Indriani Indra Teguh Wiryo Indra Teguh Wiryo Jason Jonathan Joanne Roxanne Ketut Suryana Limbara, Ermon Naftali Luh Made Mas Rusyati Made Wardhana Nareswari, Putu Ayu Diah Ni Made Dwi Puspawati Ni Putu Candra Nirmalasari P Nyoman Suryawati Patricia Dian Putri Prima Saraswati Sanjiwani Sudarsa Putri, Patricia Dian Putu Ayu Diah Nareswari Putu Ayu Diah Nareswari Rahardjo, Fresa Nathania Velava Kumar Gopal Wiryo, Indra Teguh